Patents Represented by Attorney Carl A. Castellan
  • Patent number: 4148987
    Abstract: Monoethylenically unsaturated derivatives of substituted benzophenones or acetophenones which are prepared by reaction of such a benzophenone or acetophenone with a vinyl benzyl halide, such as the chloride, are polymerizable to form homopolymers or copolymers e.g. with a wide variety of conventional ethylenically unsaturated monomers, especially monoethylenically unsaturated vinyl or vinylidene monomers. The resulting polymers are sensitive to radiation, such as ultraviolet light, e.g. having a wave length of 2,000 to 5,000 angstroms, and readily cross-link or cure upon exposure to such radiation. Adhesives, binders, coatings, and impregnating compositions are made from the polymers.
    Type: Grant
    Filed: May 4, 1977
    Date of Patent: April 10, 1979
    Assignee: Rohm and Haas Company
    Inventor: Donald A. Winey
  • Patent number: 4054717
    Abstract: Mineral coating compositions for coating papers, the binder of which comprises a negatively-charged latex or an aqueous dispersion of an emulsion polymer, with or without an amylaceous binder, as the major portion thereof, and a relatively small amount of a water-soluble addition polymer having polymerized therein from 20% to 100%, preferably at least 40%, by weight of a monoethylenically unsaturated monomer having a primary, secondary, or tertiary amine group, such as an aminoalkyl acrylate, methacrylate, vinyl ether or vinyl sulfide, an N-aminoalkyl(meth)acrylamide, an N-acryloxyalkyl-oxazolidine or an N-acryloxyalkyl-tetrahydro-1,3-oxazine.
    Type: Grant
    Filed: November 19, 1975
    Date of Patent: October 18, 1977
    Assignee: Rohm and Haas Company
    Inventors: Robert A. Gill, Joseph J. Latimer, Arthur D. Jordan, Jr.
  • Patent number: 4048298
    Abstract: The present invention is concerned with the radioimmunoassay (RIA) procedure for assaying body fluid content of an antigenic substance which may either be an antigen itself or a hapten capable of being converted, such as by means of reaction with a protein, to an antigenic material. The present invention is concerned with a novel and improved modification of a double-antibody RIA technique in which there is a first antibody that is specific to the antigenic substance suspected to be present in a body fluid from which the assay is intended. The second antibody, however, is not specific to the antigenic substance or analyte, but is an antibody against the first antibody.
    Type: Grant
    Filed: February 25, 1975
    Date of Patent: September 13, 1977
    Assignee: Rohm and Haas Company
    Inventor: Gordon Dean Niswender
  • Patent number: 4029774
    Abstract: This invention relates to novel organophosphorothiolates and phosphorodithioates of the formula: ##STR1## wherein Y is oxygen or sulfur;R is (C.sub.1 -C.sub.4) alkyl;R' is (C.sub.3 -C.sub.6) alkyl;X is halogen, nitro, trifluoromethyl, (C.sub.1 -C.sub.5) alkyl or (C.sub.1 -C.sub.5) alkoxy;X' is halogen, trifluoromethyl, (C.sub.1 -C.sub.5) alkyl or (C.sub.1 -C.sub.5) alkoxy;M and m' are the same or different and are integers from 0 to 3;To compositions containing them, and to methods of using them to control pests.
    Type: Grant
    Filed: May 12, 1975
    Date of Patent: June 14, 1977
    Assignee: Rohm and Haas Company
    Inventor: William S. Hurt
  • Patent number: 4009284
    Abstract: Thioureas of the general structure Ary1NHC(S)-NR.sup.1 R.sup.2 are useful as antidiarrheal, antimotility or antisecretory agents. Particularly useful are those wherein Aryl is 2-methylphenyl and NR.sup.1 R.sup.2 is NHCH.sub.2 CH.sub.2 OH.
    Type: Grant
    Filed: December 3, 1975
    Date of Patent: February 22, 1977
    Assignee: Rohm and Haas Company
    Inventors: Peter L. De Benneville, Jack N. Moss, Esam Z. Dajani
  • Patent number: 4008319
    Abstract: This invention relates to novel organophosphorothiolates and phosphorodithioates of the formula: ##STR1## wherein R is a (C.sub.1 -C.sub.4) alkyl group;R' is a (C.sub.3 -C.sub.6) alkyl group;Y is an oxygen atom or a sulfur atom;X is a halogen atom, a (C.sub.1 -C.sub.5) alkyl group, a (C.sub.1 -C.sub.5) alkoxy group, a trifluoromethyl group, a cyano group, or a group of the formula: ##STR2## wherein R" is a hydrogen atom or a (C.sub.1 -C.sub.3) alkyl group; X' is a halogen atom, a nitro group, a (C.sub.1 -C.sub.5) alkyl group, a (C.sub.1 -C.sub.5) alkoxy group, a trifluoromethyl group, a cyano group, or a group of the formula: ##STR3## wherein R" is a hydrogen atom or a (C.sub.1 -C.sub.3) alkyl group; and M AND M' ARE THE SAME OR DIFFERENT AND ARE INTEGERS FROM 0 TO 3;To compositions containing them and to methods of using them to control pests.
    Type: Grant
    Filed: May 12, 1975
    Date of Patent: February 15, 1977
    Assignee: Rohm and Haas Company
    Inventor: William S. Hurt
  • Patent number: 3992333
    Abstract: The present invention is concerned with new and improved binders for the production of foamed or cellular articles which have a high degree of absorbency, and retain their bonded character as well as absorbency through numerous wash-dry cycles. The cellular articles are bonded by a novel self-cross-linking binder comprising a copolymer of (a) N-methylol-amine or -amide units, (b) sulfonic acid units which contain no basic nitrogen atoms or group, and (c) certain acrylic units of neutral but mildly hydrophilic character which contain no basic nitrogen atoms or group.
    Type: Grant
    Filed: June 27, 1972
    Date of Patent: November 16, 1976
    Assignee: Rohm and Haas Company
    Inventors: William D. Emmons, Vincent J. Moser, John G. Brodnyan, Norman Shachat
  • Patent number: 3991180
    Abstract: A method for treating exocrine pancreatic insufficiency is disclosed. The method comprises the administration of a stable solid medicinal preparation containing finely particulated lipase intimately admixed with Hammarsten's casein and a tabletting lubricant, whereby a hydraulic pressure of about 2000 to about 5000 psi is employed.
    Type: Grant
    Filed: October 7, 1974
    Date of Patent: November 9, 1976
    Assignee: Rohm and Haas Company
    Inventors: Fred E. Boettner, Clifford E. Neubeck
  • Patent number: 3983099
    Abstract: The present invention is concerned with the production of novel derivatives of thyroid hormones which are useful in the radioimmunoassay (RIA) of such hormones. The invention is particularly concerned with derivatives of thyroxine and triiodothyronine which contain an additional phenol group which is readily iodinatable so that the phenol conjugate can be readily tagged with a radioactive iodine isotope, such as .sup.125 I or .sup.131 I, without detrimentally interfering with the ability of the tagged conjugate so competitively bind with the naturally occurring thyroid hormone in the biological liquid to be analyzed by RIA technique. The invention is also concerned with the iodine-tagged derivatives or conjugates.
    Type: Grant
    Filed: March 19, 1975
    Date of Patent: September 28, 1976
    Assignee: Micromedic Diagonistics, Inc.
    Inventor: Gordon Dean Niswender
  • Patent number: 3981863
    Abstract: The present invention is concerned with novel derivatives of cyanocobalamin (vitamin B.sub.12), especially of the monocarboxylic acid hydrolysates thereof, by which (1) an antigenic conjugate thereof with a protein is obtainable and (2) a readily iodinatable aromatic ring can be introduced while retaining in each instance, the essential constitution of cyanocobalamin to such an extent that (a) the antigenic protein conjugate, when introduced into the blood stream of a vertebrate, causes the formation of an antibody which is specific to the cyanocobalamin portion of the conjugate and (b) unmodified cyanocobalamin and the second-mentioned derivative when tagged or labeled with radioactive-iodine competitively bind on the aforementioned antibody. Thus, the present invention provides cyanocobalamin derivatives which are quite useful in radioimmunoassay (RIA) of vitamin B.sub.12.
    Type: Grant
    Filed: February 25, 1975
    Date of Patent: September 21, 1976
    Assignee: Micromedic Diagonistics, Inc.
    Inventors: Gordon Dean Niswender, James M. Hudson
  • Patent number: 3962420
    Abstract: Macroreticular resins have shown biological activity for gallstone removal and lowering serum cholesterol by selective adsorption of cholesterol from the bile.
    Type: Grant
    Filed: July 3, 1974
    Date of Patent: June 8, 1976
    Assignee: Rohm and Haas Company
    Inventors: Michael C. Seidel, Evan H. Crook