Abstract: An antacid tablet is prepared which contains a combination of an antacid ingredient, sugar, and fat and which has a hardness requiring no more than 9 pounds peak force to cause a blunt probe to penetrate its surface. Included also are processes for preparing such a tablet in which an antacid ingredient, sugar, and melted fat are mixed, cooled and milled to produce a powdered mixture, and the mixture formed into tablets. Further improvements include using a fine sugar, 90% of which will pass a 200 mesh screen; maintaining the plungers and dies of the tableting machine above the melting point of the fat; and utilizing a limited pressure (50 to 600 pounds per square inch) in the compressing of the tablets. Another feature involves controlling the moisture to within 3 to 10% based on the weight of the tablet.

Abstract: The synthesis of 1.alpha.,25-dihydroxycholesterol, 1.alpha.,25-dihydroxy-7-dehydrocholesterol and 1.alpha.,25-dihydroxycholecalciferol and other sterol derivatives from bile acids. Also the synthesis of 3,6-diketo steroids useful in the production of 1.alpha.,25-dihydroxycholesterol and other sterols which are biologically active or can be converted to biologically active sterols. The invention involves the sterols so produced and the processes by which they are prepared.

Abstract: A service cloth having on its top side patches of hook fiber cloth, and bags containing weight material, each of the bags having on one side thereof a patch of hook fiber cloth, the hook fibers of the patches on the bags being pressed into intermeshing and interlocking engagement with the fibers of the patches on the top of the service cloth, the hook fibers being yieldable and resilient to permit such engagement and to permit disengagement upon the application of sufficient force. Also the provision of a flap portion of the service cloth which is foldable over the body of the cloth and attachable, in the same manner, to provide a pocket.

Abstract: The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing two cysteine moieties, each of which is protected by an n-alkylthio group, or when one of such moieties is in an amino terminal position, this one moiety may be protected by a cysteine group while the other is protected by an n-alkylthio group, and placing such intermediate peptide in a solution substantially free of oxygen and preferably at a pH of from 5 to 10 until rearrangement has taken place, to yield a cyclic disulfide peptide. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.

Abstract: Drafts of preselected weight are sliced into a preselected number of slices by passing the material to be sliced through a curtain of radiation to measure the density of the material, and this measurement is used to calculate the length of each draft, which measurement is stored and subsequently read out to control the operation of a stepping hydroelectric motor which pushes the material through a cutting station at the proper speed.

Abstract: A dissecting board having a glass base and a plastic cutting pad on top of the glass base, the pad being of a thickness and hardness to permit pinning a specimen on the pad and to permit some penetration of the dissecting knife but to prevent contact of the knife with the glass base and consequent dulling of the knife during normal practice of dissection; and a pan in which such board and dissected specimen may be contained when being moved and whereby spillage of liquids is avoided. Also processes in which a specimen to be dissected is pinned to the pad, dissected, removed and the board cleaned for reuse, and processes in which the board is placed in a container and moved to another position, more particularly where the glass base is tinted and the specimen photographed against the tinted glass base. A further feature is the provision of a permanent printed scale in an edge portion of the glass base.

Abstract: The synthesis of 25-hydroxycholesterol and 25-hydroxycholecalciferol from animal bile starting materials in which hyodeoxycholic acid or an ester thereof is converted to the 3.beta.-hydroxy-5-cholenic acid alkyl ester, and this is converted to 3.beta.-hydroxy-25-cyano-5-cholene by a series of steps by which the sterol nucleus is stabilized by placing a protecting group at the 3 position and then extending the chain from the carbon at the 24 position to a cyanide group at the 25 position. The compound so formed is subjected to a series of reactions by which it is transformed into 25-hydroxy-7-dehydrocholesterol which may then be irradiated with ultraviolet light to 25-hydroxycholecalciferol. The invention discloses new and improved processes for preparing these end products and also new compounds formed as intermediates and processes for preparing these intermediates.

Abstract: The synthesis of 1.alpha.,25-dihydroxycholesterol, 1.alpha.,25-dihydroxy-7-dehydrocholesterol and 1.alpha.,25-dihydroxycholecalciferol and other sterol derivatives from bile acids. Also the synthesis of 3,6-diketo steroids useful in the production of 1.alpha.,25-dihydroxycholesterol and other sterols which are biologically active or can be converted to biologically active sterols. The invention involves the sterols so produced and the processes by which they are prepared.

Abstract: A tool for cutting materials such as animal carcasses and portions of carcasses one after another, the tool including a cutting blade and a guard member, together with means for discharging against the blade and against the guard member hot water at sterilizing temperature for sterilizing the cutting blade and guard between their use in cutting different carcasses. The disclosure also deals with a process in which one carcass is cut using the tool, the tool withdrawn and the blade and guard then treated by discharging sterilizing water thereon before the tool is again used in the cutting of other carcasses.

Abstract: A tool for cutting materials such as animal carcasses and portions of carcasses one after another, the tool including a cutting blade and a guard member, together with means for discharging against the blade and against the guard member hot water at sterilizing temperature for sterilizing the cutting blade and guard between their use in cutting different carcasses. The disclosure also deals with a process in which one carcass is cut using the tool, the tool withdrawn and the blade and guard then treated by discharging sterilizing water thereon before the tool is again used in the cutting of other carcasses.

Abstract: The synthesis of 25-hydroxycholesterol from animal bile starting materials in which hyodeoxychloic acid or an ester thereof is converted to the 3.beta.-hydroxy-5-cholenic acid alkyl ester, and then converted to 3.beta.-hydroxy-25-cyano-5-cholene by a series of steps in which the sterol nucleus is stablized by use of a 3.alpha.,5.alpha.-bridge sometimes called an i-steroid configuration, and the carbon chain then extended from the carbon at the 24-position to a cyanide group at the 25-position. The compound so formed is subjected to a series of reactions by which it is transformed into 25-hydroxy-7-dehydrocholesterol which may then be irradiated with ultraviolet light to 25-hydroxycholecalciferol. The invention discloses new and improved processes for preparing these end products and also the compounds formed as intermediates and processes for preparing these intermediates.

Abstract: Peptides having adrenocorticotropic hormone activity and resin peptides useful in preparation of such peptides, particularly such peptides having asparagine at the carboxyl end thereof and more particularly such peptides having from 19 to 25 amino acids in their amino acid chains. The invention further involves new processes for the preparation of such peptides.

Abstract: A device for storing bicycles in a building such as a garage where there is space over the hood of an automobile parked in a garage. The device includes brackets or means for attaching the device to the frame structure of the building, and a rack on which the bicycles are mounted, the rack being pivotally connected with the brackets so that the rack may be turned forwardly about its pivot to bring the rack and bicycles thereon from vertical to horizontal position. Another feature is means associated with the brackets and the rack to prevent the rack from turning the wrong way about its pivot. Another feature involves clamping means for grasping the inclined members of a bicycle frame near the center of gravity of the bicycle frame. Another embodiment includes means for mounting a rack such as above referred to at the rear end of an auto.

Abstract: Drafts of preselected weight are sliced into a preselected number of slices by passing the material to be sliced through a curtain of radiation to measure the density of the material, and this measurement is used to calculate the length of each draft, which measurement is stored and subsequently read out to control the operation of a stepping hydroelectric motor which pushes the material through a cutting station at the proper speed.

Abstract: Ampholytic quaternary ammonium compounds according to the formula: ##STR1## where R, R.sub.1 and R.sub.2 each is an alkyl group containing a carbon chain of from 1 to 22 carbon atoms, R.sub.3 is H, CH.sub.3 or CH.sub.3 CH.sub.2, R.sub.4 is H or CH.sub.3, and X is COOH, CN, CHO, or COOCH.sub.3 and methods for preparing such compounds wherein a tertiary amine is reacted with an .alpha.,.beta. unsaturated compound to produce an intermediate reaction product and this intermediate reaction product is reacted with an alkylene oxide to produce the ampholytic quaternary ammonium compound.

Abstract: The preparation of a resin impregnated glass fiber sheet wherein a layer of thermosetting resin is deposited on a cover film, a layer of glass fibers formed over the resin layer, and the film carrying the resin and glass fiber layer passed downwardly between a pair of spaced rolls while controlling the rate at which the resin is deposited in accordance with the speed at which the glass fiber layer is passed between said rolls, to maintain a pool of resin between the rolls as the apparatus continues to operate.

Abstract: Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R--CH.sub.2 --O--Phe--Asn at one end of an amino acid chain, R being the resin and Phe and Asn being the residues of the amino acids phenylalanine and asparagine; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological acitivity may be derived.

Abstract: Peptide amides having biological activity and resin peptide amides useful in the preparation of peptides having biological activity, particularly such peptides containing the structure ##STR1## in which R is divinylbenzene crosslinked polystyrene and Bz is benzyl, p-methoxybenzyl, p-chlorobenzyl, p-nitrobenzyl, or benzhydryl, and in which phe and glu are residues of the amino acids phenylalanine and glutamic acid; and processes for preparing such peptide amides.Resin peptide amides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptide amides are disclosed which contain amino acid chains in which the amino acid residues differ in kind or sequence from amino acid chains of natural biologically active peptides but from which peptides having biological activity may be derived.

Abstract: A peptide chosen from the group comprising [Ala.sup.1 ]-HPTH-(1-X) and HPTH-(1-X) wherein X is an integer from 27 to 34.

Abstract: Resin peptides useful in the preparation of salmon calcitonin are disclosed along with processes for preparing the same. The invention also embraces peptides from which the resin moiety has been cleaved and which are useful in the synthesis of salmon calcitonin together with processes for preparing the cleaved peptides. In general, the processes involve the solid phase synthesis procedures.