Patents Represented by Attorney, Agent or Law Firm Carol Francis
  • Human neurogenin 3-encoding nucleotide sequences
    Patent number: 6703220
    Abstract: The present invention features a human neurogenin3 (Ngn3) polypeptide and nucleotide sequences encoding Ngn3 polypeptides. In a particular aspect, the polynucleotide is the nucleotide sequence of SEQ ID NO:1. In addition, the invention features isolated nucleic acid sequence comprising an Ngn3 promoter, as well as a polynucleotide sequences that hybridize under stringent conditions to SEQ ID NO:1. In related aspects the invention features expression vectors and host cells comprising polynucleotides that encode a human Ngn3 polypeptide.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: March 9, 2004
    Assignee: The Regents of the University of California
    Inventors: Michael S. German, Joseph Lin
  • Tankyrase H, compositions involved in the cell cycle and methods of use
    Patent number: 6617102
    Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: September 9, 2003
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ying Luo, Eva Chan, Xiang Xu, Betty Huang, Valeria Ossovskaya