Patents Represented by Attorney, Agent or Law Firm Carol S. Quagliato
  • Microbial transformation of a substituted pyridinone using actinoplanacete sp. MA 6559
    Patent number: 5185251
    Abstract: Fermentation of the microorganism Actinoplanacete sp. (MA6559), ATTC No. 53771, in the presence of the HIV reverse transcriptase inhibitor ##STR1## yields 3-[2-(benzoxazol-2-yl)ethyl]-5-(1-hydroxyethyl)-6-methyl-2(1H)-pyridinone and 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-hydroxymethyl-2(1H)-pyridinone, both of which are useful in the prevention or treatment of infection by HIV and the treatment of AIDS.
    Type: Grant
    Filed: June 7, 1991
    Date of Patent: February 9, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Shieh-Shung T. Chen, George Doss
  • Method of hydroxylating substituted 3-aminopyridinones using mammalian tissue
    Patent number: 5169769
    Abstract: Incubation of ##STR1## with a preparation from mammalian organ yields as biotransformation products the 6-hydroxymethyl and 5-(1-hydroxy)ethyl anologs. These products are useful in the prevention or treatment of infection by HIV and the treatment of AIDS.
    Type: Grant
    Filed: June 7, 1991
    Date of Patent: December 8, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Suresh K. Balani, Byron H. Arison, Harri G. Ramjit, Anthony D. Theoharides, Laura R. Kauffman
  • Stereoselective production of hydroxyamide compounds from chiral .alpha.-amino epoxides
    Patent number: 5169952
    Abstract: An efficient process for stereoselective preparation of a medicinally significant hydroxyamide compound of structural formula: ##STR1## comprises the addition of metalated amide enolates to chiral .alpha.-amino metalated epoxides. The hydroxyamide reaction products are useful as inhibitors of the HIV protease or of renin, or as intermediates in the preparation of inhibitors of the HIV protease or renin.
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: December 8, 1992
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Ralph Volante, Michael Wallace, Ichiro Shinkai
  • Method to reduce introacular pressure without causing miosis
    Patent number: 5153205
    Abstract: Topical administration of a cholinomimetic agent, such as pilocarpine, in combination with a cholinergic M.sub.3 receptor antagonist, such as 4-diphenyl-acetoxy-N-methylpiperidine, to the eye of a mammal reduces intraocular pressure without the concommitant miotic effect that normally occurs with administration of a cholinomimetic agent along.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: October 6, 1992
    Assignee: Merck & Co., Inc.
    Inventor: Victor J. Lotti
  • Humoral hypercalcemic factor antagonists
    Patent number: 5149779
    Abstract: Peptide analogues of human humoral hypercalcemic factor (hHCF) that contain a lactam bridge act as inhibitors of the naturally occurring peptide. A lactam bridge between Lys and Asp situated five residues (inclusive) apart confers rigidity to that region of the peptide, and enhances the helical nature and metabolic stability of the peptide analogue.
    Type: Grant
    Filed: July 26, 1990
    Date of Patent: September 22, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Michael Chorev, Eli Roubini
  • Methods for detackification of paint spray operation wastes
    Patent number: 5143624
    Abstract: Poly(diallylamine) blended with poly(N-methylolacrylamide) effectively detackifies over-sprayed paint in the circulating water of a wet paint spray booth operation. After detackification the dispersed paint is flocculated with hydrolyzed polyacrylamide, the paint waste is removed, and the clarified water is recirculated back into the paint spray booth operation.
    Type: Grant
    Filed: May 2, 1991
    Date of Patent: September 1, 1992
    Assignee: Calgon Corporation
    Inventor: Lewis D. Morse
  • HIV reverse transcriptase
    Patent number: 5124327
    Abstract: Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds or pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: September 6, 1991
    Date of Patent: June 23, 1992
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, P. C. Srinivasan