Abstract: Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors.

Abstract: The disclosed system and method allow secure packet transmission to be provided with a minimum amount of overhead and to employ a cache having copies distributed among a plurality of different locations. SSL/TLS session information for a session with each of the proxy servers is stored in the cache so that it is accessible to at least one other proxy server. Using this arrangement, when a client computer switches from a connection with a first proxy server to a connection with a second proxy server, the second proxy server can retrieve SSL/TLS session information from the cache corresponding to the SSL/TLS communication session between the client device and the first proxy server. The second proxy server can then use the retrieved SSL/TLS session information to accept a session with the client device.

Abstract: A heat exchanger having an active surface over which a fluid flows to affect an exchange of heat between the active surface and the fluid. In some embodiments, the active surface includes a logarithmic spiral wherein the radius of the logarithmic spiral measured at equiangular radii unfolds at a constant order of growth. Further embodiments exhibit an active surface conforming to the internal or external surface of particular classes or genera of shells.

Abstract: The present invention provides a system and method for determining the necessary departure time to allow for an on-time or desired arrival time at a particular location over a particular route based on the evaluation of historic, present, and predicted road conditions.

Abstract: Methods for optical isolation in high peak power fiber-optic systems prevent damage to a facet within a fiber-optic isolator caused by back-reflected light from, for example, an optical amplifier. Preventing damage to the facet may include expanding a mode area of the back-reflected light and/or reducing a change in refractive index.

Abstract: A pipelined x86 processor implements a method of detecting self-modifying code in which a prefetched block of instruction bytes may contain an instruction that is modified by a store instruction preceding it in the execution pipeline. The processor includes a Prefetch unit having a multi-block prefetch buffer, a Branch unit with a branch target cache (BTC), and a Load/Store (LDST) unit having store reservation stations.