Patents Represented by Attorney Catharine D. Fitch

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  • Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
    Patent number: 5719296
    Abstract: Compounds of the formula ##STR1## are inhibitors of peptide binding to major histocompatibility complex type II proteins and are useful in the treatment and prevention of autoimmune diseases including: rheumatoid arthritis, Type I diabetes, multiple sclerosis, lupus erythematosis, Graves disease and pemphigus. The present invention also provides novel compositions, methods of treatment employing the compounds of the present invention and methods of manufacture of the compounds of structural formula (I).
    Type: Grant
    Filed: October 28, 1996
    Date of Patent: February 17, 1998
    Assignee: Merck & Co., Inc.
    Inventors: John J. Acton, III, Alan D. Adams, Jeffrey D. Hermes, A. Brian Jones, William Hugh Parsons, Peter J. Sinclair