Patents Represented by Attorney Charles F. Costello, Jr.
  • Patent number: 5725497
    Abstract: An implant dart has a head of solid material and a tubular body that contains one or more drug-delivery implant packages. The head has a blade at its front end with a chisel type point with a beveled end and a scooped face extending rearwardly to the body. The body is formed as a helical coil that makes the body tubular and permits the coil turns to be compressed and engage to make the body relatively rigid when the dart is injected into the subject. A passage from the head to the interior of the body provides fluid communication between the subject's body fluids and the implant packages. Wings extend from the head to guide entry of the dart into the subject and to lock it against withdrawal. The complete system comprises at least one dart and an injection mechanism which retains a subject's body part on a platen and feeds darts into the body part and generally parallel to the platen.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 10, 1998
    Assignee: American Cyanamid Company
    Inventors: Keith F. Woodruff, David Alan Peterson, Kendra Beth Eager
  • Patent number: 5723695
    Abstract: There is provided a safe, efficient process for the production of sodium C.sub.4 -C.sub.8 alkoxide which utilizes a less than stoichiometric quantity of a C.sub.4 -C.sub.8 alcohol and the option of a continuous recycle of the unreacted sodium metal.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: March 3, 1998
    Assignee: American Cyanamid Company
    Inventors: Jan Hendrik Wevers, Robert Jan Hendrik Scheffer
  • Patent number: 5711956
    Abstract: A solid formulation which comprises polyvinylpyrrolidone and a pyrethroid insecticide, for example alpha-cypermethrin, is disclosed for use in the treatment of animals, for example cattle. Also disclosed are uses of the solid formulation and methods which use the solid formulation in the treatment of animals.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: January 27, 1998
    Assignee: American Cyanamid Company
    Inventors: David John Wedlock, Jonathan Mark Woodburn
  • Patent number: 5709871
    Abstract: A water dispersible solid formulation comprising an active ingredient, a surfactant of non-ionic type, a surfactant of anionic type and at least 30 wt % of urea is disclosed. A process of preparing the formulation and the use of the formulation for delivering an active ingredient, for example a pesticide or plant growth regulant to an agricultural or horticultural locus are also described.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: January 20, 1998
    Assignee: Shell Research Limited
    Inventor: Alister Christie Hill
  • Patent number: 5707928
    Abstract: The present invention provides herbicidal emulsifiable suspension concentrate compositions of imidazolinyl benzoic acids, or esters or salts thereof, and dinitroaniline herbicides. Such compositions have improved low temperature stability.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: January 13, 1998
    Assignee: American Cyanamid Company
    Inventor: Ivor Philip Baker
  • Patent number: 5705454
    Abstract: The present invention relates to chemical compositions comprising imidazolinone compounds that are suitable for use in turfgrass management. The invention also provides methods for altering the growth and reducing mowing frequency, suppressing seed head formation and controlling undesirable vegetation in turfgrass.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: January 6, 1998
    Assignee: American Cyanamid Company
    Inventors: Prithvi Raj Bhalla, Robert Michael Herrick, Donald Wakeford Gates
  • Patent number: 5693594
    Abstract: A compound of general formula (I) wherein: A represents a group of general formula (1) or (2) in which each X independently represents a halogen atom or an optionally substituted alkyl, cycloalkyl, alkoxy, aryl or aryloxy group, or an alkenyloxy, alkynyloxy, alkylthio, haloalkylthio, alkenylthio, alkynylthio, alkylsulphinyl, alkylsulphonyl or cyano group; and n is 0, an integer from 1 to 4, or, for the phenyl group, 5; or A represents a group of general formula (3) in which each of R.sup.4, R.sup.5 and R.sup.6 independently represents a hydrogen or halogen atom, an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, alkaryl alkoxy, amino, mono- or di-alkylamino, alkoxycarbonylamino, arylamino, dialkylcarbamoyl, acyl or acylamido group or a cyano group, with the proviso that R.sup.5 and R.sup.6 do not represent an acyl, acylamido or cyano group; Z represents an oxygen or sulphur atom; R.sup.1 and R.sup.
    Type: Grant
    Filed: April 25, 1996
    Date of Patent: December 2, 1997
    Assignee: American Cyanamid Company
    Inventors: Hans-Peter Niedermann, Dieter Gutheil
  • Patent number: 5677303
    Abstract: Enolethers and thioenolethers of formula I ##STR1## are disclosed. The compounds are useful for combatting phytopathogenic fungi.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: October 14, 1997
    Assignee: American Cyanamid Company
    Inventors: Juergen Curtze, Guido Albert
  • Patent number: 5635449
    Abstract: The present invention provides arylthioalkyl- and arylthioalkenylphosphonic acids and derivatives thereof having the structural formula I ##STR1## Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: June 3, 1997
    Assignee: American Cyanamid Company
    Inventors: Charles M. Langevine, John M. Finn
  • Patent number: 5627175
    Abstract: The invention is directed to azoxycyanobenzene derivatives of the formula: ##STR1## wherein n is 0-3; each R represents halogen, nitro, cyano, alkyl, haloalkyl, alkoxy, or haloalkoxy; and each R.sup.1 and R.sup.2 represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, or aralkyl group. The compounds may be used as fungicides.
    Type: Grant
    Filed: July 24, 1995
    Date of Patent: May 6, 1997
    Assignee: ShellInternationale Research Maatschappij B.V.
    Inventor: Werner E. J. Simon
  • Patent number: 5616708
    Abstract: Compounds of the following formula are provided: ##STR1## in which R.sup.1 represents a hydrogen atom or an optionally substituted alkyl, cycloalkyl, haloalkyl, alkenyl, alkynyl, aryl or aralkyl group,A and B both represent a nitrogen atom, or represents a group CR.sup.5 and B represents a nitrogen atom or a group CR.sup.6 ;R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each independently represent a hydrogen or halogen atom, a hydroxy or cyano group or an optionally substituted alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, aralkyl, aryl, alkylamino, alkylthio or alkoxy group; andl represents an integer from 1 to 3.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: April 1, 1997
    Assignee: Shell Research Limited
    Inventor: Waldemar F. A. Pfrengle
  • Patent number: 5614635
    Abstract: The present invention provides an improved method for the preparation of pyridine-2,3-dicarboxylic acids by the continuous oxidation of substituted quinolines.
    Type: Grant
    Filed: August 16, 1995
    Date of Patent: March 25, 1997
    Assignee: American Cyanamid Company
    Inventor: Paul E. Miller
  • Patent number: 5612345
    Abstract: The invention relates to fungicidal compositions which comprise a carrier and, as active ingredient, a dihalotriazolopyrimidine derivative of general formula (I) in which R represents an optionally substituted branched or straight-chain alkyl or alkoxy group or an optionally substituted cycloalkyl, aryl, aryloxy, or heterocyclyl group, and Hal represents a fluorine, chlorine, bromine or iodine atom; and their use as fungicides. Certain of these dihalotriazolopyrimidine derivatives are novel and a process for the preparation of these compounds is also provided.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 18, 1997
    Assignee: Shell Internationale Research Maatschappij B.V.
    Inventors: Heinz-Manfred Becher, Klaus-Jurgen Pees
  • Patent number: 5599818
    Abstract: Spiroheterocyclic compounds having fungicidal activity are disclosed having the formula: ##STR1## in which X is O or CH.sub.2 ; R.sup.1 is hydrogen or optionally substituted alkyl, cycloalkyl, haloalkyl, alkenyl, alkynyl, aryl or aralkyl; R.sup.2 is optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, alkoxyalkyl, aryl or aryloxy, or together with the ring to which they are attached represents a polycyclic hydrocarbyl group; A and B both represent nitrogen, or A represents the group CR.sup.5 and B represents nitrogen or CR.sup.6 ; 1 is an integer from 1 to 3; m is zero or an integer from 1 to 6; and n represents zero or an integer from 1 to 3.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: February 4, 1997
    Assignee: Shell Research Limited
    Inventor: Waldemar F. A. Pfrengle
  • Patent number: 5540716
    Abstract: A surgical fastener is comprised of a center span with two locking arms extending therefrom, each locking arm containing an indentation adapted to receive a locking point and an indentation adapted to receive a locking nub. An inner bendable member extends from the center span terminating in a staple point member, the staple point member terminating in a tissue piercing point. An outer bendable member extends from the staple point member parallel to the inner bendable member, terminating in a locking point and locking nub. In the closed position the locking point of the outer bendable member locks into the indentation in the locking arm, to lock the staple in the closed position. In the open position the locking nub of the outer bendable member locks into the locking nub indentation in the locking arm to hold the staple in the open position.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: July 30, 1996
    Assignee: American Cyanamid Company
    Inventor: Robert A. Hlavacek
  • Patent number: 5536582
    Abstract: An aqueous silicone coating composition containing a reactive siloxane polymer and a non-reactive dimethylpolysiloxane in an aqueous carrier having an effective amount of at least one dispersing agent to disperse the siloxanes throughout the aqueous carrier. Also provided is a method of lubricating substrates by applying an aqueous silicone coating composition to the substrate and curing the silicone thereon, as well as lubricated surgical needles prepared by that method.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: July 16, 1996
    Assignee: American Cyanamid Company
    Inventors: Janniah S. Prasad, Dario Vitali
  • Patent number: 5508251
    Abstract: A method of combating undesired plant growth at a locus is disclosed, the method comprising applying to the locus a compound of general formula: ##STR1## where R.sup.1 and R.sup.2 independently represent a hydrogen atom or an optionally substituted alkyl or alkenyl group or R.sup.1 and R.sup.2 together represent an optionally substituted alkyl or alkenyl chain;R.sup.3 represents an optionally substituted saturated or unsaturated homocyclic or heterocyclic group; and Z represents a group --COOR.sup.4 where R.sup.4 represents a hydrogen atom, a cation or an optionally substituted alkyl, alkenyl, alkynyl or aryl group, or Z represents a group --CHO.The use of a compound of general formula I as a herbicide and a herbicidal composition are also disclosed.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: April 16, 1996
    Assignee: American Cyanamid Company
    Inventors: Trevor W. Newton, Binne Zwanenburg
  • Patent number: 5475093
    Abstract: The invention relates to a process for the preparation of azoxycyanide compounds of the general formula ##STR1## in which R represents an optionally substituted aryl or heterocyclyl group, which comprises treating a compound of the general formulaR--N.dbd.O (II)in which R is as defined above, with cyanamide or a metal salt thereof and a compound of the general formula ##STR2## in which R.sup.1 represents an optionally substituted alkyl or aryl group and R.sup.2 represents a hydrogen atom or an optionally substituted alkyl or aryl group or R.sup.1 and R.sup.2 together represent a group ##STR3## where m is 2, 3, 4 or 5, k is 0 or 1 and each of R.sup.3 and R.sup.4 independently represents a hydrogen atom or an alkyl group, and X represents a chlorine, bromine or iodine atom or a cyano or --SO.sub.2 R.sup.5 group where R.sup.5 represents a hydrogen atom or an optionally substituted alkyl or aryl group. Compounds of general formula I exhibit biocidal activity.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: December 12, 1995
    Assignee: American Cyanamid Co.
    Inventor: Werner E. J. Simon
  • Patent number: 5472439
    Abstract: A reusable endoscopic surgical instrument includes a handle assembly attached to a slender shaft assembly. The shaft assembly includes inner and outer shafts, with the inner shaft being rotatable by operation of the handle assembly to rotate a surgical tool operably connected to the distal end of a pushrod disposed within the inner shaft. The handle assembly includes first actuating mechanism for actuating the pushrod to operate the surgical tool and a second actuating mechanism for rotating the inner shaft. The outer shaft is axially slidable with respect to the inner shaft to cover a flush port system in the handle assembly for cleaning and improved sterilizability of the instrument.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: December 5, 1995
    Assignee: American Cyanamid Company
    Inventor: Stanley M. Hurd
  • Patent number: 5456922
    Abstract: The present invention relates to compositions of water dispersible and water soluble carbohydrate polymers and biologically active macromolecules of growth hormones, somatomedins, growth factors, and other biologically active fragments which are suitable for parenteral administration. The present invention also relates to a method for increasing and for maintaining increased levels of growth hormone in the blood of treated animals for extended periods of time, increasing weight gains in animals, and increasing milk production of lactating animals by the administration of the compositions of the invention.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: October 10, 1995
    Assignee: American Cyanamid Company
    Inventors: Susan M. Cady, Richard Fishbein, Ulf Schroder, Hakan Eriksson, Brenda L. Probasco