Abstract: In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The invention relates to a biomaterial which can successively carry out a solution/gel transition then a gel/solution transition with given kinetics, said biomaterial comprising at least one monomer which may form polymers, at least one enzyme which may decompose said polymers and, optionally, an enzyme which may form covalent bonds between said monomers. The invention further relates to a method for the production of said biomaterial.

Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

Abstract: A method of allocating frequency ranges to at least one communication device is provided. The method comprises determining available frequency ranges within a plurality of frequency ranges, combining the available frequency ranges to at least one combined logical frequency range, and allocating the at least one combined logical frequency range to the at least one communication device.

Abstract: In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Abstract: A method for making a conductive film of carbon nanotubes includes the steps of: a) preparing a carbon nanotube solution having a viscosity ranging from 1 to 50 c.p. at room temperature and containing a plurality of multi-walled carbon nanotubes; b) atomizing the carbon nanotube solution to form a plurality of atomized particles including the carbon nanotubes; c) providing a carrier gas to carry the atomized particles to a substrate disposed on a spin coating equipment; and d) spin coating the atomized particles on the substrate to form a conductive film of carbon nanotubes on a surface of the substrate.

Abstract: A method of determining available frequency ranges for at least one communication device is provided. The method comprises providing a downlink transmission time interval, determining available frequency ranges within a plurality of frequency ranges after the downlink transmission time interval, and providing an uplink transmission time interval after the determining of the available frequency ranges.

Abstract: The invention is the provision of an elongated imitation wood product or component which has a plastic core and a plastic coating on at least one surface with the coating, which is of two different colours and which has a randomly swirled pattern, giving a realistic appearance of the wood grain of natural wood to the product. The invention further is in the method and equipment for producing such a realistic imitation wood product or component made of plastic.

Abstract: The present invention provides a system for enhancing clearance or destruction of undesirable cells or noncellular molecular entities by tagging such cells or noncellular molecular entities with a marker that targets the cells or noncellular molecular entities for phagocytosis (phagocytic marker). The target cells can be, for example, endothelial cells, tumor cells, leukocytes, or virus-infected cells. In certain embodiments of the invention the tagging is accomplished by administering a composition comprising an antibody or ligand linked to the phagcytotic marker, wherein the antibody or ligand binds to a cell type specific marker present on or in the cell surface of a target cell. In preferred embodiments of the invention, the phagocytic marker comprises phosphatidylserine or a group derived from phosphatidylserine, thrombospondin-1, annexin I, or a derivative of any of these.

Abstract: A run-flat support system and method for installing the same are disclosed. In one embodiment, the run-flat support system includes a torque assembly removably coupled to a split wheel rim of a pneumatic tired wheel. Support segments are adapted for attachment to the torque assembly in order to support the pneumatic tired wheel in a flat condition such as an under-inflated condition or deflated condition. Lateral support structures, which may include the form of a wedge, are secured to the support segments to provide a bead lock between beads of the interior side walls of the pneumatic tired wheel and the split wheel rim.

Abstract: A method of manufacturing a biopolymer optical waveguide includes providing a biopolymer, unwinding the biopolymer progressively to extract individual biopolymer fibers, and putting the unwound fibers under tension. The tensioned fibers are then cast in a different polymer to form a biopolymer optical waveguide that guides light due to the difference in indices of refraction between the biopolymer and the different polymer. The optical fibers may be used in biomedical applications and can be inserted in the body as transmissive media. Printing techniques may be used to manufacture the biopolymer optical waveguides.

Abstract: The present invention provides compounds having formula (I): (I) wherein n, R1-R5, Ra-Rb, Q, Y1 and Y2 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis.

Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Abstract: The present invention provides systems that allow reliable multiplexed transformation of Drosophila embryos. The present invention provides methods and reagents that allow preparation of injection-quality nucleic acid samples and that allow simultaneous preparation of multiple such samples. The present invention provides systems for simultaneous processing of multiple injected embryos. The present invention provides methods for transformation of Drosophila embryos involving use of virginator strains that can be used to increase the efficiency of setting up the crosses needed to produce the eggs for the injections and for the crosses needed to screen for transformants.

Abstract: A method for producing a composite nanoparticle, including the steps of, collapsing at least a portion of a polyelectrolyte polymer in solution about one or more precursor moieties to form a composite precursor moiety having a mean diameter in the range between about 1 nm and about 100 nm, wherein the polyelectrolyte polymer has an extended conformation in a first solution state and a more compact conformation in a second solution state; and cross-linking the polyelectrolyte polymer of the composite precursor moiety to form a composite nanoparticle wherein the precursory moiety is a charged organic ion.

Abstract: A secure fax transmission system can be used to assure the intended recipient of a confidential document being sent via facsimile is the only person that will have access to the document once it is sent. An application module communicates with a client user interface over a first network and communicates with a recipient fax machine over a second network. The application module receives information associated with a confidential document being sent via facsimile. Prior to sending the document, the application module determines if the recipient fax number has been previously registered as a secure fax number. The application module then sends the document to the recipient if the recipient fax number is registered a secure. If the recipient fax number is not registered as secure, the application module sends a request for registration to the recipient fax number.

Abstract: Disclosed are hydrochloride and tosylate crystalline salt forms of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I and methods of preparing the same.

Abstract: The present invention features the use of compstatin and complement inhibiting analogs thereof for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, choroidal neovascularization, and/or retinal neovascularization. The invention also provides compositions comprising compstatin or a complement inhibiting analog thereof and a second therapeutic agent. The invention also provides compositions comprising compstatin or a complement inhibiting analog thereof and a gel-forming material, e.g., soluble collagen, and methods of administering the compositions.

Abstract: This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling; variants and derivatives of the polynucleotides and corresponding polypeptides; uses of the polynucleotides, polypeptides, variants and derivatives; and methods and compositions for the amelioration of symptoms caused by bone remodeling disorders. Disclosed in particular are, the isolation and identification of polynucleotides, polypeptides, variants and derivatives involved in osteoclast activity, validation of the identified polynucleotides for their potential as therapeutic targets and use of the polynucleotides, polypeptides, variants and derivatives for the amelioration of disease states and research purposes.

Abstract: A shock-absorbing suspension device includes a mounting rod adapted to be mounted on a frame of a wheeled vehicle, a wheel rod adapted to be mounted on a wheel axle to transmit a shock force generated as a result of movement of the vehicle over an uneven road surface, a counteracting member pivotally mounted on the wheel rod, upper and lower linking bars connected to the mounting rod and the counteracting member to form a four-bar linkage mechanism so as to dampen the shock force, and first and second arms pivotally connected to each other and respectively connected to the wheel rod and the mounting rod so as to stabilize movement of the mounting rod in an upright direction.