Abstract: A switch matrix is disclosed for keypads used in devices such as primary control points for automation systems in homes vehicles, or businesses. The switch matrix preferably includes a support frame for supporting a grid of key positioning members arranged in a series of rows and columns. The key positioning members each preferably include cantilevers which can be deflected by pressing the keys to activate switches associated with the keypad. The cantilevers preferably have knobs which are received in corresponding openings in the keys so that the keys can be removably attached to the cantilevers with a compression fit. This allows keys of different sizes and shapes to be easily attached to the keypad in various configurations without the need for different attaching devices for each situation.

Abstract: Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong hydrophilicity and high negative charge. Amphiphilic heparin derivatives were synthesized by conjugation to bile acids, sterols, and alkanoic acids, respectively. These heparin derivatives were slightly hydrophobic, exhibited good solubility in water, and have high anticoagulation activity. These slightly hydrophobic heparin derivatives are efficiently absorbed in the gastrointestinal tract and can be used in oral dosage forms. Methods of using these amphiphilic heparin derivatives and similarly modified macromolecules for oral administration are also disclosed.

Abstract: An in-wall coin bank with novelty face. The bank features a novelty face with an entertainment feature. The entertainment feature responds when a deposit is made, amusing or entertaining the user. The face may be detachable, different types of faces with entertainment features are possible. Methods of using the bank for saving are also disclosed and claimed.

Abstract: A repositional and reusable automobile advertising banner, for attachment at the top exterior surface of the automobile windshield. The banner contains disclosure information to facilitate the sale of the car, including areas for entry of additional and varying information. When installed, the banner allows an unencumbered view of the entire width of the windshield, allowing the car to be test-driven without removal of the banner. Methods for use of the banner are also disclosed.

Abstract: A system for parking automobiles in a garage which uses a single-drive mechanism to simultaneously move automobile platforms. The automobile platforms reside in contiguous storage towers and are stacked in multiple levels. The automobile platforms simultaneously move in the towers. In one tower, the platforms move upward while the platforms in the other tower move downward. The automobile platforms rest on movement chains which move vertically among the various levels. The automobile platforms are moved from the vertical movement chains to a lateral movement means to move horizontally from tower to tower. The vertical movement system is powered by single-drive mechanism through a series of gears, sprockets and chains. Horizontal movement in the upper and lower lateral transfer areas is done by a lateral movement means.

Abstract: A pool cover system including a pool cover collecting drum supported for rotation on its ends and a drive gear connected to the drum by a drive shaft. A power gear is operably connected to a portable electric drill by a power shaft, engaging the drive gear. Upon activation of the drill, the collecting drum rotates retracting the pool cover. A complementary apparatus on the same side of the pool, such as a rope reel collecting apparatus having an engageable drive gear and a drive shaft connected to a reel, extends the pool cover over the pool by pulling on a rope attached to a rigid end of the pool cover. The pool cover is extended and retracted with the sides sliding in one channel of a dual channel track, allowing the cover to serve as a safety cover.

Abstract: A method for generating and amplifying closed circular DNA having a specific sequence in vitro in a cell-free system is disclosed. Prior to the invention of this method, closed circular DNA could only be amplified in vivo in appropriate host cells. The essence of the method is the inclusion of a thermostable DNA ligase in a PCR reaction. This procedure is referred to as ligation-during-amplification (LDA), in which the fully extended DNA strands are ligated by the DNA ligase and used as templates for subsequent amplification. Closed circular DNA having a specific sequence can be selectively amplified exponentially by the use of two sequence-specific primers in the LDA reaction. In addition, one or more site-specific mutations can be introduced into a closed circular DNA by the use of one or more mutagenic primers in the LDA reaction. Various thermostable DNA polymerases and thermostable ligases can be used for LDA amplification.

Abstract: An apparatus for mechanically stimulating a human user includes in one embodiment a base frame, a rigid plate connected to the base frame and having an area sufficient to support a standing human, a vibrational device attached to the bottom of the horizontal plate whereby the plate is caused to oscillate in both vertical and horizontal directions at a desired frequency with an amplitude of less than 2.0 mm, and a frequency control device whereby the frequency of the vertical and horizontal oscillations may be selectively and independently adjusted. Vertically extending handrails are preferably connected to the device such that vibrations may be transmitted to the arms and upper spinal region of a user's body when grasped.

Abstract: A textured whey protein product for use as a meat extender or meat analog is prepared by thermoplastic extrusion of a composition containing whey protein concentrate and optionally an edible polysaccharide, such as cornstarch. Puffing of the extruded product results in a snack food product. Methods of making the meat extender product and the snack food product are also included.

Abstract: A variable-ratio transmission device. A first translational member is pivotally intercoupled to a first rotational member by at least one connecting arm. The connecting arm has a first portion pivotally connected to the first translational member at a first pivot point, and a second portion pivotally and adjustably connected to the first rotational member at a first radial attachment point removed from the center of rotation of the first rotational member. The first radial attachment point and the center of rotation thereby define a first attachment radius. The location of the first radial attachment point with respect to the first rotational member is variable to thereby increase and decrease the first attachment radius, which in turn modifies a ratio of movement between the first rotational member and the first translational member.

Abstract: Formulations for enhanced mucosal absorption of heparin are disclosed. In one embodiment, a powdered heparin composition is made by dissolving an amphiphilic heparin derivative including heparin covalently bonded to a hydrophobic agent in a water phase, dispersing the water phase in an organic phase such that an emulsion is formed, and drying the emulsion. In another embodiment, an amorphiphilic heparin derivative dispersed in an oil phase is made by dissolving the amphiphilic heparin derivative in water or a water/organic co-solvent, dispersing the water or co-solvent in the oil phase, and evaporating the water or co-solvent. In another embodiment, heparin-containing nanoparticles having surfactant molecules associated with a hydrophobic agent on the outside of the nanoparticles are made by dissolving the amphiphilic heparin derivative in an aqueous solvent, mixing the surfactant with the aqueous solvent, and disrupting nanoparticles of the amphiphilic heparin derivative.

Abstract: A method for making a directed antisense library against a target transcript is described. A cDNA of the target transcript is cloned in an appropriate cloning vector. Next, a plurality of deletion derivatives of the cloned cDNA is prepared such that the deletions serially extend into the cDNA from one end thereof. The resulting deletion library is then treated such that cDNA is removed from the other end of each cDNA insert, thus obtaining a fragment library having fragments of a selected size. A catalytic core is then inserted into each fragment of the fragment library, resulting in the directed antisense library. An illustrative antisense gene in the hammerhead ribozyme catalytic core. Plasmids for making the antisense library, plasmids and methods for making the fragment library, and a method for identifying target sites for antisense-mediated gene inhibition are also described.

Abstract: A flashlight with unique flashlight electrical connections, including a switch structure featuring a switch requiring a small amount of force, and a short stroke distance to actuate, attached to a member on which a circuit adding additional functions to the flashlight may be located. The member has conductive springs attached to either end that are used to complete the electrical circuit with the battery and the lamp, while their compressive force is absorbed by a housing protecting the switch structure. A conductive strip is used to improve the conductivity of the circuit in a metal flashlight which has been provided with an electrically resistive protective coating.

Abstract: An intervertebral spacer adapted for implanting between adjacent vertebral bodies of a human spine as a load-bearing replacement for a spinal disc. The spacing member includes an external, non-porous, concavo-convex contour with respect to one dimension of said spacing member. The spacing member is preferably constructed from a rigid, non-resilient load-bearing material that is incapable of elastic deformation. The spacing member is inserted with the aid of a sheathed trocar device that is releasably attached to the spacer, to enable implantation and selective positioning of the spacer by the surgeon from the posterior side of the spine, without the need to retract the dural nerve or the posterior longitudinal ligament.

Abstract: A dietary supplement blend composition is disclosed, the basic formulation of the composition containing vitamins, minerals, and carotenoids. The composition can also contain bioflavonoids, cartilage protectors such as glucosamine or chondroitin, &agr;-lipoic acid, coenzyme Q10, and a source of omega-3 fatty acids such as flax seed oil. The composition is beneficial for improving health and preventing disease, particularly for degenerative conditions. A method for supplementing the diet is also disclosed, wherein the quantity of daily rations of the dietary supplement blend composition is determined based on the person's age, body weight, and quality of diet.

Abstract: A compound isolated from an aqueous leachate of heartwood of “Palo de Brazil” Caesalpinia brasiliensis has antihypertensive activity. The compound was isolated by reversed-phase high pressure liquid chromatography to separate it from haematoxylin, which is co-extracted with the new compound. The compound is effective in reducing the blood pressure of hypertensive Sprague-Dawley rats.

Abstract: A system for endosteal tibial ligament fixation with adjustable tensioning is disclosed. A grasping hook located on a shaft is used to draw a ligament graft into a contoured drill hole formed in a bone. A series of slanted ridges on the shaft can pass in only one direction through a securing push nut residing in the contoured drill hole, resulting in an interference fit that secures the attachment system, while allowing the tension of the ligament graft to be adjusted.

Abstract: A toy including a base made of a flexible sheet and painted or printed to have the appearance of grass, streets, rivers, lakes, and the like, and one or more structures configured for being reversibly folded into a flattened shape and unfolded to resemble houses, schools, churches, airports, and the like is described. Preferably, the structures are reversibly attachable to the base, such as with a hook-and-loop fastener.