Abstract: A method for converting a pseudoisocytidine base having the formula: to a pseudoisocytidine molecule having the formula: is disclosed. Such compounds are useful as nucleic acid labeling compounds.

Abstract: The invention includes compositions and methods for depleting antigen presenting cells, or for impairing the biological function of antigen presenting cells, which compositions are useful for treatment of graft versus host disease and other immune diseases.

Abstract: Compounds of the following structure: are useful as nucleic labeling compounds.

Abstract: An entertainment toy that can be disposed in multiple configurations is disclosed. In one embodiment, the entertainment toy includes a base having an upper surface, a support frame coupled to the base, and a seat that is configured to hold an infant. The seat is movably mounted on the support frame. The entertainment toy includes an output generating system. In one embodiment, the entertainment toy includes an actuator disposed on the base. The actuator is connected to the output generating system and is disposed to be engaged by a foot of the infant. The output generating system is configured to generate audible and/or visual outputs in response to activation of the actuator.

Abstract: A system accessible by a test access port controller via a test access port interface includes a data register. The data register is selectable based on an instruction register signal in the test access port interface. The instruction register signal is derived form an instruction register in the test access port controller. A shift register is connected to a data input and a data output in the test access port interface and to the data register. The operation of the shift register is controlled based on an indication of a state of a test access port controller state machine that is received over the test access port interface.

Abstract: There is provided by this invention a wafer probe for measuring plasma and surface characteristics in plasma processing environment that utilizes integrated sensors on a wafer substrate. A microprocessor mounted on the substrate receives input signals from the integrated sensors to process, store, and transmit the data. A wireless communication transceiver receives the data from the microprocessor and transmits information outside of the plasma processing system to a computer that collects the data during plasma processing. The integrated sensors may be dual floating Langmuir probes, temperature measuring devices, resonant beam gas sensors, or hall magnetic sensors. There is also provided a self-contained power source that utilizes the plasma for power that is comprised of a topographically dependent charging device or a charging structure that utilizes stacked capacitors.

Abstract: Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.

Abstract: The present invention discloses fusion proteins comprising transferrin, lactoferrin or melanotransferrin fused to glucagon-like peptide 1 (GLP-1). In one embodiment of the invention, the fusion protein displays increased serum half-life as compared to a GLP-1 peptide in an unfused state. The invention includes a pharmaceutical composition comprising the GLP-1 fusion protein of the invention and a carrier. The fusion protein of the invention can be administered to a subject for treatment of diseases or conditions treatable by GLP-1, including, but not limited to, diabetes, obesity, congestive heart failure and inflammatory bowel syndrome.

Abstract: The present invention discloses methods of making a mixture of theaflavin, theaflavin-3-gallate, theaflavin-3?-gallate and theaflavin 3,3?-digallate, pharmaceutical compositions of the above mixture of theaflavins, diet supplement compositions of the above mixture of theaflavins and methods for using the above mixtures of theaflavin and pharmaceutical compositions thereof to treat or prevent various diseases. The present invention also discloses methods of making theaflavin, theaflavin-3-gallate, theaflavin-3?-gallate and theaflavin 3,3?-digallate, each as a separate compound, pharmaceutical compositions of the above compounds, diet supplement compositions of the above compounds and methods for using the above compounds to treat or prevent various diseases.

Abstract: A policy engine generates configlets that are vendor-neutral, vendor-specific or both, based on a selected target level and a selected device/device group. A translator translates and combines the configlets to form vendor-dependent configuration files. The policy engine generates the configlets using policies associated with the selected target level and its sub-target levels, as defined by a target level hierarchy. A policy includes at least a condition, and an action which the policy engine performs if the condition is true. In performing the action, the policy engine typically writes to at least a partial configlet. A policy may further include a verification clause, which is used to verify a running configuration. Policy dependencies may also be defined such that where a second policy is dependent on a first policy, the second policy must be evaluated after the first policy. This is necessary, where, for example, the first policy generates and stores a value to be used by the second policy.

Abstract: A graphics processor includes programmable arithmetic logic units (ALUs) for performing scalar arithmetic operations on pixel packets. For a selected scalar arithmetic operation, operands in pixel packets may be formatted in a S1.8 format to improve dynamic range. For at least one other scalar arithmetic operation, the pixel packets may be formatted in a different data format.

Abstract: A cryptosystem is described which automatically provides an extra “message recovery” recipient(s) when an encrypted message is generated in the system. The system is typically configured such that the extra recipient or “message recovery agent” (MRA)—an entity which itself has a public key (i.e., a MRA public key)—is automatically added, under appropriate circumstances, as a valid recipient for an encrypted message created by a user. In a corporate setting, for example, the message recovery agent is the “corporate” message recovery agent designated for that company (firm, organization, or other group) and the user is an employee (or member) of that company (or group). In operation, the system embeds a pointer (or other reference mechanism) to the MRA public key into the public key of the user or employee, so that encrypted messages sent to the company's employees from outside users (e.g., those individuals who are not employees of the company) can nevertheless still be recovered by the company.

Abstract: A computer implemented method for mapping data from one presentation to another includes capturing and transmitting the context of an original report based on an originating data source such that it preserves the organization of the query and variable levels of context “fidelity”. The context of the originating report is translated in terms of the originating data source to a target context for presentation of a target report based on a target data source. The translation of different mapping scenarios is controlled in accordance with a translation model with a translation map.

Abstract: This invention is directed to a cassette for electrophoresis gels comprising: first and second planar wall members having inner and outer surfaces, top and bottom edges, and lateral edges wherein the wall members are oriented generally parallel to each other and such that the inner wall of each wall member is proximate to the inner wall of the other wall member; spacing means disposed between the inner walls of the wall members and adapted to provide a space for an electrophoresis gel between the inner walls of the wall members, wherein the cassette has an interior which is defined by the space between the wall members; and locking means adapted to prevent locking engagement of the members unless the inner surfaces of the wall members and are substantially parallel to each other and are separated by a predetermined distance, and when the wall members are in locked engagement, to substantially prevent any movement of the wall members away from such locked engagement.

Abstract: The invention relates to a coated article having enhanced reversible thermal properties. The coated article comprises a substrate having a surface and a coating covering a portion of the surface and comprising a polymeric material and a temperature regulating material dispersed in the polymeric material. The coating is formed with a plurality of regions of discontinuity that are separated from one another and expose a remaining portion of the surface to provide improved flexibility, softness, air permeability, or water vapor transport properties. The coated article may be used in apparel, footwear, medical products, containers and packagings, building materials, appliances, and other products.

Abstract: A bus permits the number of active serial data lanes of a data link to be re-negotiated in response to changes in bus bandwidth requirements. In one embodiment, one of the bus interfaces triggers a re-negotiation of link width and places a constraint on link width during the re-negotiation.

Abstract: A system and method for continuous online safety and reliability monitoring is disclosed. The method includes the steps of obtaining operating information about at least one of a plurality of instrumented function components, which are part of an instrumented function, and determining a probability of failure on demand for the instrumented function based on the operating information. In variations, instantaneous probability of failure on demand, online mean time to failure (MTTF), and online safety integrity level (SIL) are also calculated for an instrumented function. In other variations of the invention, alarms are reported to an operator based on the variance indicating the probability of failure on demand for the instrumented function is too high. In yet further variations, the system allows a user to predict probability of failure on demand values into the future based on hypothetical and/or future planned test times.

Abstract: A system and method for program counter and data tracing is disclosed. The tracing mechanism of the present invention enables increased visibility into the hardware and software state of the processor core.

Abstract: A translinear variable-gain amplifier. The translinear variable gain amplifier receives a differential input voltage and produces a differential output current having a selected gain. The amplifier comprises a buffer amplifier that receives the differential input voltage and produces a differential input current. The amplifier further comprises a translinear gain cell coupled to receive the differential input current and produce the differential output current. The gain cell includes a first adjustable bias source that operates to set a linear input range of the gain cell, and a second adjustable bias source that operates to set a gain value of the gain cell.

Abstract: Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached.