Patents Represented by Law Firm Cushman, Darby & Cushman Cushman, Darby & Cushman
  • Patent number: 5276016
    Abstract: Short peptide of the formula:R.sup.a -Ser-Thr-Thr-Thr-Asn-Tyr-R.sup.b (I)where R.sup.a represents an amino terminal residue Ala- or D-Ala and R.sup.b represents a carboxy terminal residue -Thr or -Thr amide or a derivative thereof with an additional Cys- residue at one or both of the amino and carboxy terminals, or a peptide of formula (II):R.sup.1 -R.sup.2 -R.sup.3 -R.sup.4 -R.sup.5 (II)whereR.sup.1 is an amino terminal residue Thr-, Ser-, Asn-,Leu-,Ile-,Arg- or Glu-R.sup.2 is Thr, Ser or AspR.sup.3 is Thr, Ser, Asn, Arg, Gln, Lys or TrpR.sup.4 is Tyr andR.sup.5 is a carboxy terminal amino group or a derivative thereof with a corresponding D- amino acid as the amino terminal residue, and/or a corresponding amide derivative at the carboxy terminal residue and/or additionally a Cys- residue at one or both of the amino and carboxy terminals,or a physiologically acceptable salt thereof.Such peptides bind to T4 receptors are useful in preventing viral infectivity by viruses which bind to the T4 receptors.
    Type: Grant
    Filed: August 16, 1990
    Date of Patent: January 4, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Candace B. Pert, Michael R. Ruff, William L. Farrar
  • Patent number: 5075096
    Abstract: Disclosed is a method of vapor-phase synthesizing diamond comprising creating a reduction atmosphere by burning a combustible gas in a combustion-supporting gas, controlling the humidity by adding steam or liquid water drops to the combustion flame, and inserting a basic material into the synthesis flame. This method produces diamonds of the desired reproducibility and crystallinity, with an industrially-acceptable rate of film growth, while simultaneously ensuring the process stability necessary for long-duration synthesis.
    Type: Grant
    Filed: January 18, 1990
    Date of Patent: December 24, 1991
    Assignee: Sumitomo Electric Industries, Ltd.
    Inventors: Keiichiro Tanabe, Naoji Fujimori
  • Patent number: 4948544
    Abstract: A process is disclosed for producting thin stretched films having a thickness between 0.1 and 20 .mu.m from polyolefins of ultrahigh molecular weight by dissolving the polyolefin in a solvent, shaping the solution at a temperature above the solution temperature of the polyolefin to a tape, cooling the tape to a temperature below the solution temperature to obtain gelation and stretching the gelled tape. In this process the gelled tape is initially subjected to a preliminary orientation in one direction, under solvent removal, and is then stretched in a direction essentially perpendicular to the direction of preliminary orientation, at elevated temperature, followed by final stretching to obtain the finished thin films. This process makes possible the production of films which are free from pores, that is to say transparent and which posses high Young's moduli, high tensile strengths and favorable values for elongation at break.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: August 14, 1990
    Assignee: Stamicarbon B.V.
    Inventors: Lambert H. T. Van Unen, Pieter B. Pluyter, Willibrordus M. G. F. Pontenagel
  • Patent number: 4405783
    Abstract: Pure hydroxypropyltheophylline is produced by the catalytic reaction of theophylline with glycidol in the presence of a hydroxide of a short chain alcoholate of an alkali metal or an alkali metal salt of a pseudohydrohalic acid which has a readily polarizable anion. The catalyst is suitably employed in an amount between 0.01 and 0.2 moles per mole of theophylline. The dihydroxypropyltheophylline is obtained directly in the reaction in a high purity.
    Type: Grant
    Filed: June 14, 1982
    Date of Patent: September 20, 1983
    Assignees: Degussa Aktiengesellschaft, Degussa Aktiengesellschaft
    Inventors: Volker Binder, Wolfgang Merk, Peter Werle
  • Patent number: 4206599
    Abstract: An internal combustion engine has a secondary air supply system and a fuel injection system including a two-fluid injection nozzle operative to inject air and fuel both under pressure into engine intake system. The secondary air supply system includes an air pump and a secondary air supply line extending between the pump and the engine exhaust system. The two-fluid injection nozzle is pneumatically connected to an air distributor provided on the secondary air supply line whereby pressurized air from the air pump is also supplied to the two-fluid injection nozzle and injected thereby together with the fuel to facilitate atomization of the injected fuel as well as to supercharge the engine.
    Type: Grant
    Filed: September 6, 1978
    Date of Patent: June 10, 1980
    Assignees: Toyota Jidosha Kogyo Kabushiki Kaisha, Aisan Industry Co., Ltd.
    Inventors: Masaharu Sumiyoshi, Setsuro Sekiya, Katsuhiko Motosugi, Junzo Uozumi, Tsuneo Ando, Yuzo Takeuchi, Mikio Minoura