Abstract: Disclosed herein are cyclic peptide derivatives of the formula ##STR1## wherein A is absent or the tripeptide radical Thr.rarw.Gly.rarw.Ala, R.sup.1 is benzyl or benzyl monosubstituted at position 4 of the aromatic ring with halo, hydroxy, lower alkyl or lower alkoxy, R.sup.2 and R.sup.4 each independently is hydrogen or lower alkyl, R.sup.3 is lower alkyl or lower alkyl monosubstituted with a hydroxy, R.sup.5 is lower alkyl, Y is oxo or thioxo and Z is hydroxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each independently is hydrogen or lower alkyl. The derivatives are useful for treating herpes infections.
Type:
Grant
Filed:
March 16, 1992
Date of Patent:
November 2, 1993
Assignee:
Bio-Mega/Boehringer Ingelheim Research Inc.
Inventors:
Julian Adams, John DiMaio, Raymond Plante
Abstract: Novel compounds having the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein. These compounds are useful in the treatment of schizophrenia.
Type:
Grant
Filed:
September 22, 1989
Date of Patent:
October 1, 1991
Assignee:
Boehringer Ingelheim KG
Inventors:
Matthias Grauert, Herbert Merz, Joachim Mierau, Gunter Schingnitz, Claus Schneider
Abstract: A derivative of 3,5,3'-triiodothyronine having the following general formula: ##STR1## in which m is an integer from 2 to 4, n is an integer from 1 to 4, and R is a monovalent, unsubstituted, fully unsaturated five- or six-membered monocyclic heterocyclic group containing either one or two nitrogen atoms as the only hetero atoms.
Abstract: Cells are identified electrophoretically through isoenzyme analysis. The use of standard and control cells allows semi-skilled workers to achieve reproducible results. A coding sequence is assigned to the cels to be identified using a grid to interpret the electrophoretic separations observed on a series of electrophoretic films, each film being developed for a particular isoenzyme. Comparison of the coding sequence with a compendium of coding sequences for known cells identifies the cells to be identified.
Type:
Grant
Filed:
September 9, 1982
Date of Patent:
November 17, 1987
Assignee:
Ciba Corning Diagnostics Corp.
Inventors:
Cyrus A. Lepp, James J. Mussatto, James M. Ziegenmeyer