Abstract: The present invention relates to orthopedic splinting articles and methods for forming orthopedic splints at least part way around an animal body part. The splinting articles comprise a unitary blank formed of an open-celled foam sheet impregnated with a water curable, isocyanate functional, polyurethane prepolymer resin. The blank is dimensioned to extend the length of the body part to be immobilized and to partially, but preferably not completely, extend around the circumference of the body part. Upon activation of the resin impregnated foam sheet and molding the same around the body part, an orthopedic splint is formed.