Patents Represented by Attorney Dana M. Foley, Hoag & Eliot LLP Gordon

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  • Synthesis of aryl ethers
    Patent number: 6166226
    Abstract: A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst selected from the group consisting of platinum and nickel to form an aryl ether. The aromatic compound comprises an activated substituent, X, said activated substituent being a moiety such that its conjugate acid HX has a pKa of less than 5.0. The catalyst is preferably a soluble palladium complex in the presence of supporting ligands.
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: December 26, 2000
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen L. Buchwald, John P. Wolfe, Michael Palucki
  • Asymmetric cycloaddition reactions
    Patent number: 6130340
    Abstract: The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of chiral or prochiral substrates that contain reactive .pi.-systems, in the present of a non-racemic chiral catalyst, to produce a stereoisomerically enriched product.
    Type: Grant
    Filed: January 13, 1998
    Date of Patent: October 10, 2000
    Assignee: President and Fellows of Harvard College
    Inventors: Eric N. Jacobsen, Scott E. Schaus
  • Quinoline-indole antimicrobial agents, uses and compositions related thereto
    Patent number: 6103905
    Abstract: The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacteria microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: August 15, 2000
    Assignee: Sepracor, Inc.
    Inventors: Gregory D. Cuny, James R. Hauske, Donald L. Heefner, Michael Z. Hoemann, Gnanasambandam Kumaravel, Anita Melikian-Badalian, Richard F. Rossi, Roger L. Xie
  • Imine hydrosilylation, uses and reagents related thereto
    Patent number: 6072085
    Abstract: The method of the present invention provides a simple general route to a wide range of secondary amines.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: June 6, 2000
    Assignee: Massachusetts Institute of Technology
    Inventors: Xavier Verdaguer, Udo E. W. Lange, Stephen L. Buchwald