Patents Represented by Attorney Darby & Cushman Cushman
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Patent number: 5276016Abstract: Short peptide of the formula:R.sup.a -Ser-Thr-Thr-Thr-Asn-Tyr-R.sup.b (I)where R.sup.a represents an amino terminal residue Ala- or D-Ala and R.sup.b represents a carboxy terminal residue -Thr or -Thr amide or a derivative thereof with an additional Cys- residue at one or both of the amino and carboxy terminals, or a peptide of formula (II):R.sup.1 -R.sup.2 -R.sup.3 -R.sup.4 -R.sup.5 (II)whereR.sup.1 is an amino terminal residue Thr-, Ser-, Asn-,Leu-,Ile-,Arg- or Glu-R.sup.2 is Thr, Ser or AspR.sup.3 is Thr, Ser, Asn, Arg, Gln, Lys or TrpR.sup.4 is Tyr andR.sup.5 is a carboxy terminal amino group or a derivative thereof with a corresponding D- amino acid as the amino terminal residue, and/or a corresponding amide derivative at the carboxy terminal residue and/or additionally a Cys- residue at one or both of the amino and carboxy terminals,or a physiologically acceptable salt thereof.Such peptides bind to T4 receptors are useful in preventing viral infectivity by viruses which bind to the T4 receptors.Type: GrantFiled: August 16, 1990Date of Patent: January 4, 1994Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Candace B. Pert, Michael R. Ruff, William L. Farrar
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Patent number: 5075096Abstract: Disclosed is a method of vapor-phase synthesizing diamond comprising creating a reduction atmosphere by burning a combustible gas in a combustion-supporting gas, controlling the humidity by adding steam or liquid water drops to the combustion flame, and inserting a basic material into the synthesis flame. This method produces diamonds of the desired reproducibility and crystallinity, with an industrially-acceptable rate of film growth, while simultaneously ensuring the process stability necessary for long-duration synthesis.Type: GrantFiled: January 18, 1990Date of Patent: December 24, 1991Assignee: Sumitomo Electric Industries, Ltd.Inventors: Keiichiro Tanabe, Naoji Fujimori
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Patent number: 4948544Abstract: A process is disclosed for producting thin stretched films having a thickness between 0.1 and 20 .mu.m from polyolefins of ultrahigh molecular weight by dissolving the polyolefin in a solvent, shaping the solution at a temperature above the solution temperature of the polyolefin to a tape, cooling the tape to a temperature below the solution temperature to obtain gelation and stretching the gelled tape. In this process the gelled tape is initially subjected to a preliminary orientation in one direction, under solvent removal, and is then stretched in a direction essentially perpendicular to the direction of preliminary orientation, at elevated temperature, followed by final stretching to obtain the finished thin films. This process makes possible the production of films which are free from pores, that is to say transparent and which posses high Young's moduli, high tensile strengths and favorable values for elongation at break.Type: GrantFiled: July 25, 1988Date of Patent: August 14, 1990Assignee: Stamicarbon B.V.Inventors: Lambert H. T. Van Unen, Pieter B. Pluyter, Willibrordus M. G. F. Pontenagel
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Patent number: 4425755Abstract: A dual fuel burner for a gas turbine engine comprises a gas fuel manifold and ducts opening into a central air passage, a liquid fuel manifold and tangentially arranged apertures opening into an annular liquid fuel passage terminating in an annular nozzle. The central air passage has an upstream swirler, and is arranged to receive a flow of compressed air at its upstream end and to discharge a flow of compressed air and either gaseous or liquid fuel from its downstream end. The burner also has a water manifold so that water can be injected into the fuel and air flow via ducts and an annular air passage, to control NOx emission.In an alternative arrangement, the liquid fuel can be injected into the annular air passage.The burner is intended to operate on a range of high calorific fuels, both liquid and gaseous, and is designed to minimize the surface area on which carbon may accumulate during operation.Type: GrantFiled: September 10, 1981Date of Patent: January 17, 1984Assignee: Rolls-Royce LimitedInventor: Eric Hughes
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Patent number: 4405783Abstract: Pure hydroxypropyltheophylline is produced by the catalytic reaction of theophylline with glycidol in the presence of a hydroxide of a short chain alcoholate of an alkali metal or an alkali metal salt of a pseudohydrohalic acid which has a readily polarizable anion. The catalyst is suitably employed in an amount between 0.01 and 0.2 moles per mole of theophylline. The dihydroxypropyltheophylline is obtained directly in the reaction in a high purity.Type: GrantFiled: June 14, 1982Date of Patent: September 20, 1983Assignees: Degussa Aktiengesellschaft, Degussa AktiengesellschaftInventors: Volker Binder, Wolfgang Merk, Peter Werle
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Patent number: 4245107Abstract: Novel cephalosporin derivatives having a higher antimicrobial activity across a broad antimicrobial spectrum. They are useful for treatment of infections caused by Gram-positive bacteria and Gram-negative bacteria. Such cephalosporin derivatives are prepared by a relatively simple method.Type: GrantFiled: September 27, 1979Date of Patent: January 13, 1981Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Chisei Shibuya, Hirataka Itoh, Yutaka Usubuchi, Mitsuaki Akamine
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Patent number: 4236988Abstract: An apparatus for measuring ion activities comprising an electrode assembly, a sample cup, a mechanism for moving up and down said electrode assembly, a pipette for injecting a sample fluid and a system for injecting a reference solution, and so operating as to inject a sample fluid into said sample cup with the pipette for injecting sample fluid, move up and down said electrode assembly for assuring intimate contact between said electrode assembly and said sample fluid, measure ion activities in said sample fluid, inject a reference solution through said reference solution injecting system, wash said electrode assembly, discard the reference solution used for washing, inject the reference solution once again, measure ion activities in said reference solution and determine correct ion activities in said sample fluid on the basis of the levels of ion activities measured in said sample solution and those measured in said reference solution.Type: GrantFiled: February 26, 1979Date of Patent: December 2, 1980Assignee: Olympus Optical Co., Ltd.Inventors: Nobuyoshi Suzuki, Shigeru Yoshinari
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Patent number: 4206599Abstract: An internal combustion engine has a secondary air supply system and a fuel injection system including a two-fluid injection nozzle operative to inject air and fuel both under pressure into engine intake system. The secondary air supply system includes an air pump and a secondary air supply line extending between the pump and the engine exhaust system. The two-fluid injection nozzle is pneumatically connected to an air distributor provided on the secondary air supply line whereby pressurized air from the air pump is also supplied to the two-fluid injection nozzle and injected thereby together with the fuel to facilitate atomization of the injected fuel as well as to supercharge the engine.Type: GrantFiled: September 6, 1978Date of Patent: June 10, 1980Assignees: Toyota Jidosha Kogyo Kabushiki Kaisha, Aisan Industry Co., Ltd.Inventors: Masaharu Sumiyoshi, Setsuro Sekiya, Katsuhiko Motosugi, Junzo Uozumi, Tsuneo Ando, Yuzo Takeuchi, Mikio Minoura
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Patent number: 4007922Abstract: The invention is an extruding device which includes a screw and a barrel wherein the screw includes a kneading portion whose cross-section differs from the cross-section of the remainder of the screw and the barrel includes a kneading portion whose cross-section differs from the cross-section of the remainder of the barrel and is opposite to the kneading portion of the screw, the cross-sections of the two kneading portions being such that the distance between a point on the periphery of the kneading portion of the screw and the nearest point on the interior surface of the barrel, measured in a radial direction, varies on rotation of the screw in the barrel. The extruding device exerts an improved kneading effect upon extruded material.Type: GrantFiled: April 14, 1975Date of Patent: February 15, 1977Assignee: Mitsubishi Jukogyo Kabushiki KaishaInventor: Yukio Tamura
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Patent number: 3994679Abstract: A process to color in blue to black shades aromatic polyester textile materials by dyeing, padding or printing an aqueous dispersion of a dyestuff mixture of three or four specific azo and anthraquinone disperse dyes.Type: GrantFiled: July 28, 1975Date of Patent: November 30, 1976Assignee: Imperial Chemical Industries LimitedInventors: Colin William Greenhalgh, Ronald Wynford Kenyon, Andrew John Logan
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Patent number: 3971687Abstract: A method of forming a double-walled unit from thermoplastic materials, preferably polymethyl methacrylate, in which two sheets, one of which is provided with an aperture to allow the passage of air between the sheets, are stretched apart under thermoforming conditions by imposed pressure differences, the desired spatial relationship between the sheets being obtained by adjustment of the pressure differences, and in which the sheets are simultaneously bonded about their perimeters.Type: GrantFiled: August 28, 1974Date of Patent: July 27, 1976Assignee: Imperial Chemical Industries LimitedInventors: Kent Reaney Greer, William Rodney Hampson, Benjamin James Smith