Patents Represented by Attorney David Berstein

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  • Synthetic multimerizing agents
    Patent number: 6150527
    Abstract: New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: November 21, 2000
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Dennis A. Holt, Terence P. Keenan, Tao Guo, Edgardo Laborde, Wu Yang
  • Method for producing factor VIII:C-type proteins
    Patent number: 5250421
    Abstract: An improved method for producing Factor VIII:c-type proteins is disclosed which involves culturing mammalian cells which are capable of expressing the protein. In accordance with this invention the cells are cultured in a medium containing an effective amount of a substance comprising (a) von Willebrand Factor-type protein, (b) a phospholipid or phospholipid mixture, or a mixture of (a) and (b).
    Type: Grant
    Filed: January 17, 1992
    Date of Patent: October 5, 1993
    Assignee: Genetics Institute, Inc.
    Inventors: Randal J. Kaufman, S. Robert Adamson
  • Production of procoagulant proteins
    Patent number: 5004803
    Abstract: Hybrid procoagulant proteins are disclosed which contain peptide sequences of human blood coagulation factors V and VIII. DNA molecules encoding these proteins and materials and methods for expressing them are also disclosed. Preferably, peptide sequence in the B domain of Factor VIII is replaced with peptide sequence derived from human Factor V.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: April 2, 1991
    Assignee: Genetics Institute, Inc.
    Inventors: Randal J. Kaufman, Debra Pittman