Abstract: A method for enriching rare cell populations from a whole blood sample by separating rare cell fractions from whole blood sample according to the relative charge density and/or the relative binding affinity for a leukocyte depletion solid phase matrix is described. The enrichment method may be operated stand alone, or as a pre or post-processing step in conjunction with a charge-flow separation method.
Type:
Grant
Filed:
October 10, 1997
Date of Patent:
September 7, 1999
Assignee:
BioSeparations, Inc.
Inventors:
David W. Sammons, Michael Manley, Joseph G. Utermohlen, Garland E. Twitty