Patents Represented by Attorney David J. Weitz

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  • Crystalline composition of farsenyl pyrophosphate synthase (IspA)
    Patent number: 7563610
    Abstract: Provided are crystals relating to Farsenyl Pvrophosphate Synthase (IspA) from E. coli and its various uses.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: July 21, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Douglas R. Dougan, David Hosfield, Yanming Zhang
  • Crystallization of the catalytic domain of human phosphodiesterase 4-D3 (PDE4-D3)
    Patent number: 7556950
    Abstract: Provided are crystals relating to human phosphodiesterase 4-D3 (PDE4-D3), methods for forming crystals comprising PDE4-D3 and crystals comprising PDE4-D3 co-crystallized with a ligand molecule, and methods of using crystals comprising PDE4-D3.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: July 7, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Ellen Chien, Douglas R. Dougan, Michelle L. Kraus, Clifford D. Mol, Gyorgy Snell
  • Crystallization of carboxyltransferase domain of Acetyl-CoEnzyme A Carboxylase 2 with a ligand
    Patent number: 7534592
    Abstract: Provided are crystals relating to the carboxyltransferase domain of human Acetyl-Coenzyme A Carboxylase 2 and its various uses.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: May 19, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Douglas R. Dougan, Clifford D. Mol, Bi Ching Sang, Gyorgy Snell, Hua Zou
  • System for performing crystallization trials
    Patent number: 7510690
    Abstract: A crystallization system is provided comprising a trial generation station configured to generate crystallization trials in trial zones of a crystallization plate; an imaging station configured to take images of crystallization trials in the crystallization plate; a transport mechanism configured to transport the crystallization plate to the imaging station after generation of the crystallization trials; and a controller including logic for causing the trial generation station to generate the crystallization trials in the crystallization plate, logic for causing the transport mechanism to transport the crystallization plate to the imaging station and logic for causing the imaging station to take images of the crystallization trials.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: March 31, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Laurent Martin, John W. Palan
  • Crystallization of histone deacetylase 2
    Patent number: 7507552
    Abstract: Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: March 24, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Ciaran N. Cronin, Mark T. Hilgers, Mark W. Knuth, Marc E. Navre, Bi Ching Sang, Robert J. Skene, Leslie W. Tari, Keith P. Wilson, Darbi Witmer, Hua Zou
  • Method for performing crystallization trials
    Patent number: 7452419
    Abstract: A method is provided for operating a crystallization system comprising identifying a screen storage plate from among the plurality of screen storage plates stored in a screen storage station, each screen storage plate having a plurality of wells that contain a screen solution and at least a portion of the screen storage plates having a selection of screen solutions that is different from the selection of screen solutions held in other screen storage plates; having a transport mechanism transport the identified screen storage plate to a screen replicator; transporting a plurality of crystallization plates to the screen replicators; and having the screen replicator transfer the screen solutions from the identified screen storage plate to the plurality of crystallization plates.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: November 18, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Laurent Martin, John W. Palan
  • Crystallization of aurora/LPL1P-related kinase
    Patent number: 7444273
    Abstract: Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: October 28, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Ciaran N. Cronin, Mark W. Knuth, Duncan E. McRee, Jacek Nowakowski, Nikola P. Pavletich, Devon A. Thompson, Robert A. Wijnands
  • System for performing crystallization trials
    Patent number: 7435379
    Abstract: A trial generation station is provided comprising: a deck configured to receive a crystallization plate from a transport mechanism, the crystallization plate including a plurality of trial zones where crystallization trials are generated; and a head configured to be moved relative to the stage, the head including a plurality of primary fluid dispensers, each fluid dispenser being configured to transfer a portion of a mother liquor from the well region of a trial zone to a sample region associated with the trial zone, and one or more secondary fluid dispensers configured to dispense a molecule solution into the sample regions of the wells, the molecule solution including the molecule to be crystallized by the system and at least one of the secondary fluid dispenser being laterally immobilized relative to one or more of the fluid dispensers.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: October 14, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Laurent Martin, John W. Palan
  • System for performing crystallization trials
    Patent number: 7435397
    Abstract: A crystallization system is provided comprising a screen generation station; a screen storage station; including a housing configured to store a plurality of screen storage plates and mechanics for retrieving a selected screen storage plate from among the plurality of screen storage plates for transport to another station a transport mechanism configured to transport a screen storage plate containing the screen solutions generated at the screen generation station to the screen storage station; and a controller.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: October 14, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Laurent Martin, John W. Palan
  • System for performing crystallization trials
    Patent number: 7431768
    Abstract: A crystallization system is provided comprising: a screen replicator configured to transfer screen solutions from wells of a screen storage plate into well regions of multiple crystallization plates; a trial generation station configured to generate crystallization trials in the trial zones of a crystallization plate; a transport mechanism configured to transport crystallization plates from the screen replicator to the trial generation station; and a controller having logic for causing the screen replicator to transfer the screen solutions from the screen storage plate to multiple crystallization plates, logic for causing the transport mechanism to transport the crystallization plates from the screen replicator to the trial generation station and logic for causing the trial generation station to generate crystallization trials in the crystallization plates.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: October 7, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Laurent Martin, John W. Palan
  • Method and system for performing crystallization trials
    Patent number: 7416710
    Abstract: A crystallization system is provided that comprises a screen replicator having a transfer mechanism configured to transfer portions of different screen solutions contained in a screen storage plate to well regions of a crystallization plate; a screen storage station including a housing configured to store a plurality of screen storage plates and mechanics for retrieving a selected screen storage plate from among the plurality of screen storage plates for transport to the screen replicator; a transport mechanism configured to transport a screen storage plate retrieved by the screen storage station to the screen replicator; and a controller including logic for causing the screen storage station to retrieve the selected screen storage plate from among the plurality of screen storage plates, logic for causing the transport mechanism to transport the selected screen storage plate from the screen storage station to the screen replicator, and logic for causing the screen replicator to transfer portions of different
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: August 26, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Laurent Martin, John W. Palan
  • Crystallization of dipeptidyl peptidase IV (DPPIV)
    Patent number: 7344852
    Abstract: Provided are crystals relating to DPPIV and its various uses.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: March 18, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Kathleen Aertgeerts, Ciaran N. Cronin, David J. Hosfield, Mark W. Knuth, Duncan E. McRee, Sridhar Prasad, Bi Ching Sang, Robert J. Skene, Robert A. Wijnands, Sheng Ye
  • Wild-type kinase domain of human Ephrin receptor A2 (EPHA2) and crystallization thereof
    Patent number: 7326552
    Abstract: Provided are crystals relating to human Ephrin Receptor A2 and its various uses.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: February 5, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Ciaran N. Cronin, Jacek Nowakowski, Nikola P. Pavletich, Devon A. Thompson
  • Crystallization of cathepsin S
    Patent number: 7319016
    Abstract: Provided are crystals relating to Cathepsin S and its various uses.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: January 15, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Ellen Chien, Douglas R. Dougan, Mark W. Knuth, Duncan E. McRee, Bi Ching Sang, Robert J. Skene, Ronald V. Swanson, Leslie W. Tari, Robert A. Wijnands
  • Crystallization of protein kinase B?/AKT1
    Patent number: 7309594
    Abstract: Provided are crystals relating to Protein kinase B?/AKT1 and its various uses.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: December 18, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Ellen Y. T. Chien, Douglas R. Dougan, Andrew J. Jennings, Michelle L. Kraus, Clifford D. Mol
  • Crystallization of c-KIT tyrosine kinase leading to autoinhibited crystal structure
    Patent number: 7303893
    Abstract: Provided are crystals relating to the autoinhibited structure of c-KIT tyrosine kinase (c-KIT) and its various uses.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: December 4, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Ellen Chien, Ciaran N. Cronin, Douglas R. Dougan, Clifford D. Mol, Bi Ching Sang, Hua Zou
  • Crystallization of AKT3
    Patent number: 7303892
    Abstract: Provided are crystals relating to AKT3 and its various uses.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: December 4, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Eric Adam, Oleg Brodsky, Mark W. Knuth, Jacek Nowakowski, Nikola P. Pavletich, Devon A. Thompson, Robert A. Wijnands
  • Crystallization of fibroblast activation protein alpha (FAP?)
    Patent number: 7297508
    Abstract: Provided are crystals relating to FAP? and its various uses.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: November 20, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Kathleen Aertgeerts, Sridhar Prasad, Vandana Sridhar, Robert A. Wijnands, Sheng Ye
  • Small volume liquid handling apparatus and method
    Patent number: 7294309
    Abstract: A fluid dispensing system comprising: a fluid container; a dispensing head in fluid communication with the fluid container; a displacement mechanism which delivers fluid from the fluid container to the dispensing head such that an aliquot of liquid is delivered to a distal end of the dispensing head where the aliquot of liquid is retained; and a pressurized gas displacement mechanism which delivers an aliquot of gas to the distal end of the dispensing head which causes the aliquot of liquid retained at the distal end of the dispensing head to separate from the distal end of the dispensing head.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: November 13, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Jeffrey B. Goldberg, William Spencer, Bruce K. Bridges
  • Crystallization of FMS-like tyrosine kinase 3
    Patent number: 7270987
    Abstract: Provided are crystals and structure coordinates relating to FMS-like tyrosine kinase 3 and its various uses.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: September 18, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Ellen Chien, Ciaran N. Cronin, Douglas R. Dougan, Kheng Lim, Clifford D. Mol, Bi Ching Sang, Garret Textor