Patents Represented by Attorney, Agent or Law Firm David K. Boone
  • Multibinding inhibitors of cyclooxygenase-2
    Patent number: 6395724
    Abstract: Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: May 28, 2002
    Assignee: Advanced Medicine, Inc.
    Inventors: J. Kevin Judice, Deborah L. Higgins, John H. Griffin