Abstract: The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases.Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

Abstract: The present invention relates to fibers, and nonwovens comprising said fibers, comprising a biodegradable copolymer, wherein the copolymer comprises at least two randomly repeating monomer units (RRMU) wherein the first RRMU monomer unit has the structure ##STR1## and the second RRMU has the structure ##STR2## wherein at least 50% of the RRMUs have the structure of the first RRMU. The present invention further relates to an absorbent article comprising a liquid previous topsheet, a biodegradable liquid impervious backsheet comprising the above fibers and/or nonwovens, and an absorbent core positioned between the topsheet and the backsheet.

Abstract: The present invention relates to a film comprising a biodegradable copolymer, wherein the copolymer comprises at least two randomly repeating monomer units (RRMU) wherein the first RRMU monomer unit has the structure ##STR1## and the second RRMU has the structure ##STR2## wherein at least 50% of the RRMUs have the structure of the first RRMU. The present invention further relates to an absorbent article comprising a liquid pervious topsheet, a biodegradable liquid impervious backsheet comprising the above film, and an absorbent core positioned between the topsheet and the backsheet.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; and(e) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: An anti-acne cosmetic composition in the form of a multiple phase water-in-oil emulsion and process for preparing thereof, wherein the composition comprises two or more aqueous phases and a coalescence inhibitor for preventing coalescence of the aqueous phases and wherein at least a first aqueous phase comprises the anti-acne active in the form of an aqueous/alcoholic solution. The composition exhibits moisturisation, anti-acne activityand skin anti-ageing benefits, together with product and colour stability.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; and(e) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.Pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pair using such compounds.

Abstract: The subject invention relates to compounds having the structure: ##STR1## wherein (a) n is an integer from 1 to about 3;(b) X and Y are each independently selected from O, S and CH.sub.2, with at least one of X and Y being O or S;(c) R is unsubstituted, straight or branched chain alkanyl or alkanoxy having from 1 to about 3 non-hydrogen atoms; and(d) R' is selected from hydrogen, methyl, cyano, and halo;pharmaceutical compositions containing such compounds; and the use of such compounds for preventing or treating of disorders modulated by alpha-2 adrenoceptors.

Abstract: Disclosed are anhydrous antiperspirant gel-solid sticks which comprise from about 0.5% to about 60% by weight of antiperspirant active; from about 1% to about 15% by weight of a gellant; from about 1% to about 50% by weight of nonpolar volatile hydrocarbon solvent having a solubility parameter of less than 8 (cal/cm.sup.3).sup.0.5, a vapor pressure of from about 0.0 1 mmHg to about 6 mmHg, and an average boiling point of less than about 250.degree. C.; and from about 0.01% to about 10% by weight of a polar, water-miscible solvent having a solubility parameter of from 12.5 (cal/cm.sup.3).sup.0.5 to about 25 (cal/cm.sup.3).sup.0.5 ; wherein the composition has a visible residue index of from about 11 to about 30 L-value, a product hardness of from about 500 gram.cndot.force to about 5,000 gram.cndot.force, and a ratio of an elastic to viscous moduli of from about 0.1 to about 100.

Abstract: The present invention relates to compositions, kits, and films formed therefrom which are useful as cosmetic or therapeutic agents, particularly as polishes for mammalian nails, as well as methods of their use. More particularly, the present invention relates to fast-drying compositions which enhance long wear through their fast-drying properties. When applied to mammalian nails, the present fast-drying compositions exhibit a 5% Diluent Content Time of less than about 38 minutes and or exhibit a 5% Diluent Content Time of less than about 44 minutes and has an Initial Slope greater than about 2.25.

Abstract: The present invention relates to conditioning shampoo compositions having improved stability and conditioning benefits. These compositions comprise a surfactant system further comprising a detersive anionic surfactant and a stabilizing surfactant; a fatty compound selected from the group consisting of fatty alcohols, fatty acids, fatty alcohol derivatives, fatty acid derivatives, and mixtures thereof; a hair conditioning agent selected from the group consisting of nonvolatile dispersed silicone conditioning agents, hydrocarbon conditioning agents, water soluble cationic polymeric conditioning agents, and mixtures thereof, and water. The present invention also relates to methods for cleansing and conditioning the hair.

Abstract: The present invention relates to solid cosmetic compositions comprising 0.1-10 wt % of a spherical silica having an average particle size of 3-16 .mu.m wherein said spherical silica is adsorped with moisturizing agent. Such composition can suppress oil shining without affecting natural finished appearance and have a moisturizing effect in a non-aqueous composition.

Abstract: The present invention relates to a process for separating polyhydroxyalkanoate from a biomass, the process comprising extracting the polyhydroxyalkanoate with at least one PHA solvent selected from the group consisting of acetone, acetonitrile, benzene, butyl acetate, butyl propionate, .beta.-butyrolactone, .gamma.-butyrolactone, diethyl carbonate, diethylformamide, dimethyl carbonate, dimethyl succinate, dimethyl sulfoxide, dimethylformamide, ethyl acetate, ethylene glycol diacetate, methyl acetate, methyl ethyl ketone, 1,4-dioxane, tetrahydrofuran, toluene, xylene, and mixtures thereof.

Abstract: Cosmetic composition in the form of a powder comprising branched chain aliphatic hydrocarbon having a weight average molecular weight of from about 100 to about 15,000 and the remainder of the composition comprising one or more cosmetic powder base components selected from pigments, matte finishing agents, fillers and binders, and mixtures thereof. The compositions provide improved adhesion to the skin, increased wear, coverage and reduced rub-off.

Abstract: The present invention relates to a process for recovering polyhydroxyalkanoate from a biological source material containing the polyhydroxyalkanoate, the process comprising: a) comminuting the biological source material; b) suspending the comminuted biological source material in a fluid; c) partitioning the polyhydroxyalkanoate from the other components of the biological source material by centrifugal fractionation to form a solid-solid separation; and d) recovering the polyhdroxyalkanoate.

Abstract: This invention involves involves the use of compounds having the following structure: ##STR1## wherein: (a) R is unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; and(b) R' is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thiol; cyano; and halo;for preventing or treating of disorders modulated by alpha-2 adrenoceptors.The subject invention also involves novel compounds and compositions.

Abstract: Disclosed are antiperspirant cream compositions which have a penetration force value of from about 20 gram.force to about 500 gram.force, and comprise (a) from about 20% to about 80% by weight of a volatile silicone material; (b) from about 5% to about 35% of a particulate antiperspirant active; and (c) from about 0.1% to about 20% by weight of a gellant material comprising glyceryl tribehenate and other triglycerides wherein at least about 75% of the esterified fatty acid moieties of said other triglycerides have from about 18 to about 36 carbon atoms, and the molar ratio of glyceryl tribehenate to said other triglycerides is from about 20:1 to about 1:1. The compositions preferably further comprise a residue masking material.

Abstract: Disclosed are anhydrous antiperspirant cream compositions that are substantially free of polymeric or inorganic thickening, and have improved product stability and spreading performance. These compositions have a rheology profile characterized by select product hardness (from about 75 gram force to about 500 gram force), delta stress (from about 300 dyne/cm.sup.2 to about 8,000 dyne/cm.sup.2) and static yield stress (at least about 1,000 dyne/cm.sup.2 ) values. The new rheology profile is preferably applied to antiperspirant cream compositions comprising from about 0.1% to about 20 % by weight of a crystalline gellant, from about 10% to about 80% by weight of an anhydrous liquid carrier for the crystalline gellant having a solubility parameter of from about 3 to about 13 and, from about 5 % to about 35% by weight of a particulate antiperspirant active.

Abstract: Disclosed are anhydrous gel deodorant compositions comprising from about 0.001% to about 50% by weight of deodorant active, fragrance, or combination thereof, from about 0.01% to about 20% by weight of a gellant; from about 1% to about 50% by weight of a nonpolar volatile solvent having a solubility parameter of less than 8.0 (cal/cm.sup.3).sup.0.5, a vapor pressure of from about 0.01 mm Hg to about 6 mm Hg at 25.degree. C., and a boiling point at 1 atm of less than about 250.degree. C.; from about 1% to about 15% by weight of a polar solvent having a solubility parameter of from 12.5 (cal/cm.sup.3).sup.0.5 to about 25 (cal/cm.sup.3).sup.0.5 and optionally a moderately polar solvent having a solubility parameter of from about 8.0 (cal/cm.sup.3).sup.0.5 to less than 12.5 (cal/cm.sup.3).sup.0.5, preferably 1,2-hexanediol. Other preferred embodiments include those which contain combinations of triclosan and triclocarban for improved deodorant efficacy.

Abstract: The present invention relates to a process for recovering polyhydroxyalkanoate from biological source material containing the polyhydroxyalkanoate, the process comprising: a) comminuting the biological source material; b) suspending the comminuted biological source material in a fluid; c) partitioning the polyhydroxyalkanoate from the other components of the biological source material by centrifugal fractionation to from a solid-solid separation; and d) recovering the polyhydroxyalkanoate.

Abstract: The present invention relates to biodegradable PHA copolymers comprising at least two randomly repeating monomer units. The present invention further relates to a plastic article comprising a biodegradable copolymer, wherein the biodegradable copolymer comprises at least two randomly repeating monomer units (RRMU) wherein the first RRMU has the structure ##STR1## wherein R.sup.1 is H, or C.sub.1 or C.sub.2 alkyl, and n is 1 or 2; the second RRMU has the structure ##STR2## wherein R.sup.2 is a C.sub.4 -C.sub.19 alkyl or alkenyl; and wherein at least 50% of the RRMUs have the structure of the first RRMU. The present invention further relates to an absorbent article comprising a liquid pervious topsheet, a liquid impervious backsheet comprising a film comprising a PHA of the present invention and an absorbent core positioned between the topsheet and the backsheet.