Patents Represented by Attorney, Agent or Law Firm Debra J. Milasincic, Esq
  • Microorganisms and assays for the identification of antibiotics
    Patent number: 6830898
    Abstract: The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previously unidentified target protein, termed CoaX. High-throughput assay systems are featured as well as assay kits for the identification of CoaX modulators. Also featured are coaX nucleic acid molecules and purified CoaX proteins, as well as recombinant vectors and microorganisms including the gene, coaX.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: December 14, 2004
    Assignee: OmniGene Bioproducts, Inc.
    Inventors: R. Rogers Yocum, Thomas A. Patterson
  • Diagnostic screens for type 1 diabetes (IDDM)
    Patent number: 6620583
    Abstract: The present invention features a method for identifying genes or proteins important in insulin-dependent diabetes mellitus (IDDM). The genes or proteins are useful in identifying IDDM-susceptible individuals, and in identifying and testing potential therapeutic agents for the treatment of IDDM.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: September 16, 2003
    Assignee: Boston Medical Center Corporation
    Inventors: Barbara E. Corkey, Nicholas R. Husni
  • Regulation of cytokine production in a hematopoietic cell
    Patent number: 6495331
    Abstract: A method useful for regulating cytokine production by a hematopoietic cell by regulating an MEKK/JNKK-contingent signal transduction pathway in such a cell is disclosed. Methods of identifying compounds capable of specifically regulating an MEKK/JNKK-contingent signal transduction pathway in hematopoietic cells, a kit for identifying cytokine regulators, methods to treat diseases involving cytokine production, and cells useful in such methods are also set forth.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: December 17, 2002
    Assignee: National Jewish Center for Immunology and Respiratory Medicine
    Inventors: Erwin W. Gelfand, Gary L. Johnson
  • MSP-18 protein and nucleic acid molecules and uses therefor
    Patent number: 6391602
    Abstract: Novel MSP-18 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length MSP-18 proteins, the invention further provides isolated MSP-18 fusion proteins, antigenic peptides and anti-MSP-18 antibodies. The invention also provides MSP-18 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a MSP-18 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: May 21, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Mehran M. Khodadoust
  • Human MEKK proteins, corresponding nucleic acid molecules, and uses therefor
    Patent number: 6312934
    Abstract: Isolated nucleic acid molecules encoding human MEKK proteins, and isolated MEKK proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and nonhuman transgenic animals carrying a human MEKK transgene. The invention further provides human MEKK fusion proteins and anti-human MEKK antibodies. Methods of using the human MEKK proteins and nucleic acid molecules of the invention are also disclosed, including methods for detecting human MEKK activity in a biological sample, methods of modulating human MEKK activity in a cell, and methods for identifying agents that modulate the activity of human MEKK.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: November 6, 2001
    Assignee: National Jewish Center for Immunology and Respiratory Medicine
    Inventor: Gary L. Johnson