Patents Represented by Attorney, Agent or Law Firm Denise L. Loring
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Patent number: 6790857Abstract: This invention provides a method for preparing a benzoylecgonine composition comprising the steps of: (a) contacting benzoylmethylecgonine and propylene glycol in the presence or absence of water to form a reaction mixture; (b) maintaining the reaction mixture at a temperature between about 50° and 100° C.; and (c) subsequently or simultaneously removing water from the reaction mixture. This invention also provides novel benzoylecgonine and methods for producing them.Type: GrantFiled: November 13, 2002Date of Patent: September 14, 2004Assignee: Entropin, Inc.Inventor: Nicholas James Archer
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Patent number: 6482831Abstract: The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. Accordingly, this invention also relates to pharmaceutical compositions and methods for their use.Type: GrantFiled: April 26, 2000Date of Patent: November 19, 2002Assignee: Entropin, Inc.Inventors: James E. Wynn, Lowell M. Somers
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Patent number: 5376667Abstract: The present invention relates to a novel class of benzoylecgonine, ecgonine and ecgonidine derivatives which are useful for preventing and treating immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. The compounds of this invention are conveniently obtained by chemical synthesis. Accordingly, this invention also relates to methods for preparing the benzoylecgonine, ecgonine and ecgonidine derivatives and to pharmaceutical compositions containing these derivatives.Type: GrantFiled: December 31, 1992Date of Patent: December 27, 1994Assignee: Entropin, Inc.Inventors: Lowell M. Somers, James E. Wynn
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Patent number: 5354665Abstract: A phosphatidylinositol (PI)-linked form of the LFA-3 polypeptide, which binds to CD2 molecules on the surface of T lymphocytes, in provided. Soluble polypeptides derived from the native sequence are also disclosed. DNA sequences, vectors, and transformed unicellular hosts useful for making these polypeptides are provided. Methods for using the LFA-3 polypeptides in therapy an diagnosis are described.Type: GrantFiled: October 13, 1992Date of Patent: October 11, 1994Assignee: Biogen, Inc.Inventors: Barbara P. Wallner, Catherine Hession
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Patent number: 5272254Abstract: DNA sequences, hybrid DNA sequences, recombinant DNA molecules and processes for producing streptavidin-like polypeptides and for producing fused proteins consisting of a streptavidin-like polypeptide joined end to end with another protein, polypeptide, peptide or amino acid. The DNA sequences, hybrid DNA sequences and recombinant DNA molecules of this invention are characterized in that they include DNA fragments that code for streptavidin-like polypeptides. These DNA sequences, hybrid DNA sequences and recombinant DNA molecules and the hosts transformed with them may be employed in the processes of this invention to produce streptavidin-like polypeptides and fused proteins.Type: GrantFiled: November 27, 1991Date of Patent: December 21, 1993Assignee: Biogen Inc.Inventors: Harry M. Meade, Jeffrey L. Garwin
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Patent number: 5258340Abstract: This invention relates to improved catalysts for the oxidation of carbon monoxide and methods of preparing these catalysts. The catalysts of this invention are prepared using a sequential precipitation process which generates catalysts that contain substantially layered metal oxides, both supported and unsupported, and, in some embodiments of the invention, a noble metal or mixture of noble metals layered on the metal oxides. These catalysts are particularly useful in smoking articles.Type: GrantFiled: February 15, 1991Date of Patent: November 2, 1993Assignee: Philip Morris IncorporatedInventors: Robert L. Augustine, Setrak Tanielyan
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Patent number: 5223394Abstract: DNA sequences derived from a phosphatidylinositol-linked form of lymphocyte function-associated antigen 3 ("LFA-3") are provided which code for a phosphatidylinositol linkage signalling sequence. The linkage signalling sequence may be linked to DNA coding for secretory proteins or polypeptides to obtain phosphatidylinositol-linked chimeric proteins or polypeptides. The chimeric proteins can be used to produce targeted drugs, to form micellular or liposomal drug delivery systems, or to improve the purification or screening of particular cells, proteins or DNA libraries.Type: GrantFiled: April 10, 1989Date of Patent: June 29, 1993Assignee: Biogen, Inc.Inventor: Barbara P. Wallner
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Patent number: 5185441Abstract: Polypeptides that bind to CD2, the receptor on the surface of T-lymphocytes. Most preferably, the polypeptides are soluble. DNA sequences that code on expression and/or secretion in appropriate unicellular hosts for those polypeptides.Type: GrantFiled: August 26, 1988Date of Patent: February 9, 1993Assignee: Biogen, Inc.Inventors: Barbara P. Wallner, Catherine Hession
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Patent number: 5168049Abstract: DNA sequences, hybrid DNA sequences, recombinant DNA molecules and processes for producing streptavidin-like polypeptides and for producing fused proteins consisting of a streptavidin-like polypeptide joined end to end with another protein, polypeptide, peptide or amino acid. The DNA sequences, hybrid DNA sequences and recombinant DNA molecules of this invention are characterized in that they include DNA fragments that code for streptavidin-like polypeptides. These DNA sequences, hybrid DNA sequences and recombinant DNA molecules and the hosts transformed with them may be employed in the processes of this invention to produce streptavidin-like polypeptides and fused proteins.Type: GrantFiled: April 21, 1988Date of Patent: December 1, 1992Assignee: Biogen, Inc.Inventors: Harry M. Meade, Jeffrey L. Garwin
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Patent number: 5081019Abstract: DNA sequences, recombinant DNA molecules and hosts transformed with them which produce human lipocortin-like polypeptides and methods of making and using these products. The DNA sequences and recombinant DNA molecules are characterized in that they code on expression for a human lipocortin-like polypeptide. In appropriate hosts these DNA sequences permit the production of human lipocortin-like polypeptides useful as anti-inflammatory agents and methods in the treatment of arthritic, allergic, dermatologic, ophthalmic and collagen diseases as well as other disorders involving inflammatory processes.Type: GrantFiled: May 2, 1990Date of Patent: January 14, 1992Assignee: Biogen, Inc.Inventors: Barbara P. Wallner, R. Blake Pepinsky
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Patent number: 5040552Abstract: An iron carbide heat source, particularly useful in smoking articles, is provided. The iron carbide particles making up the heat source have ignition temperatures that are substantially lower than conventional carbon particles normally used in carbonaceous heat sources, while at the same time provide sufficient heat to release a flavored aerosol from a flavor bed for inhalation by the smoker. In a preferred embodiment, the iron carbide heat source of this invention is substantially cylindrical in shape and has one or more fluid passages therethrough. Upon combustion, the heat source produces substantially no carbon monoxide.Type: GrantFiled: December 8, 1988Date of Patent: August 20, 1991Assignee: Philip Morris IncorporatedInventors: Donald M. Schleich, Yunchang Zhang
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Patent number: 4950646Abstract: DNA sequences, recombinant DNA molecules and hosts transformed with them which produce human lipocortin-like polypeptides and methods of making and using these products. The DNA sequences and recombinant DNA molecules are characterized in that they code on expression for a human lipocortin-like polypeptide. In appropriate hosts these DNA sequences permit the production of human lipocortin-like polypeptides useful as anti-inflammatory agents and methods in the treatment of arthritic, allergic, dermatologic, ophthalmic and collagen diseases as well as other disorders involving inflammatory processes.Type: GrantFiled: January 10, 1986Date of Patent: August 21, 1990Assignee: Biogen, Inc.Inventors: Barbara P. Wallner, R. Blake Pepinsky, Jeffrey L. Garwin, Daniel G. Schindler, Kuo-Sen Huang
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Patent number: 4879224Abstract: DNA sequences, recombinant DNA molecules and hosts transformed with them which produce human phospholipase inhibitor polypeptides and methods of making and using these products. The DNA sequences and recombinant DNA molecules are characterized in that they code on expression for a human phospholipase inhibitor polypeptide. In appropiate hosts these DNA sequences permit the production of human phospholipase inhibitor polypeptides.Type: GrantFiled: January 10, 1985Date of Patent: November 7, 1989Assignee: Biogen, Inc.Inventors: Barbara P. Wallner, R. Blake Pepinsky, Jeffrey L. Garwin
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Patent number: 4874743Abstract: DNA sequences, recombinant DNA molecules and hosts transformed with them which produce human phospholipase inhibitor-like polypeptides and methods of making and using these products. The DNA sequences and recombinant DNA molecules are characterized in that they code on expression for a human phospholipase inhibitor-like polypeptide. In appropriate hosts these DNA sequences permit the production of human phospholipase inhibitor-like polypeptides useful as anti-inflammatory agents and methods in the treatment of arthritic, allergic, dermatologic, ophthalmic and collagen diseases as well as other disorders involving inflammatory processes.Type: GrantFiled: March 15, 1985Date of Patent: October 17, 1989Assignee: Biogen, Inc.Inventors: Barbara P. Wallner, R. Blake Pepinsky, Jeffrey L. Garwin
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Patent number: 4871829Abstract: The invention relates to organomineral products of high strength obtainable by reacting a polyisocyanate in an aqueous alkali silicate solution in the presence of a catalyst prompting the trimerization of the polyisocyanate. In preparing them, the catalyst is used in an amount of 5.5 to 14.5 mmole per mole of NCO groups in the reaction mixture. The organo-mineral products of the invention are suitable as construction, coating, sealing or insulating materials or as putty or adhesives.Type: GrantFiled: March 13, 1989Date of Patent: October 3, 1989Assignees: KVT Kunststoffverfahrenstechnik GmbH & Co., F. William GmbH & Co.Inventor: Karl-Heinz Hilterhaus
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Patent number: 4827005Abstract: The invention relates to organomineral products of high strength obtainable by reacting a polyisocyanate in an aqueous alkali silicate solution in the presence of a catalyst prompting the trimerization of the polyisocyanate. In preparing them, the catalyst is used in an amount of 5.5 to 14.5 mmole per mole of NCO groups in the reaction mixture. The organomineral products of the invention are suitable as construction, coating, sealing or insulating materials or as putty or adhesives.Type: GrantFiled: June 5, 1985Date of Patent: May 2, 1989Assignees: KVT Kunststoffverfahrenstechnik GmbH & Co., F. Willich GmbH & Co.Inventor: Karl-Heinz Hilterhaus
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Patent number: 4716112Abstract: Improved expression vectors for amplifying expression of DNA sequence encoding a desired polypeptide beyond that expected by the vector copy number. The vector contains a DNA sequence within the replicon of the vector encoding RNA I and the primer RNA for initiation of DNA replication and their regulatory regions, said DNA sequence having an AT to GC mutuation at position 3029 in the two strands of pBR322; a promoter of RNA I or primer RNA and a restriction site for insertion of a DNA sequence encoding a desired polypeptide into the vector and operatively linking the DNA sequence to the expression control sequence. The AT to GC mutation causes an increase in the vector copy number and further amplifies the expression of the desired polypeptide operatively linked to the RNA I or primer RNA promoter beyond that expected by the copy number increase.Type: GrantFiled: February 11, 1986Date of Patent: December 29, 1987Assignee: Biogen N.V.Inventor: Nikos Panayotatos