Patents Represented by Attorney Diana Hamlet-King

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  • Protease-resistant thrombomodulin analogs
    Patent number: 5863760
    Abstract: The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 26, 1999
    Assignee: Schering Altiengesellschaft
    Inventors: David Richard Light, William H. Andrews, Jeffrey Homer Clarke, Robert Michael Wydro, Patricia Ann Young
  • Protease-resistant thrombomodulin analogs
    Patent number: 5827824
    Abstract: The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 27, 1998
    Assignee: Schering Aktiengesellschaft
    Inventors: David Richard Light, William H. Andrews, Jeffrey Homer Clarke, Robert Michael Wydro, Patricia Ann Young
  • (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
    Patent number: 5633381
    Abstract: This invention relates to novel (Z,Z), (Z,E) and (E,Z) olefin isomers of substituted benzylidene cycloketones and their pharmaceutically acceptable salts. The compounds of the invention are potent factor Xa inhibitors thereby acting as anticoagulants useful in a number of thrombotic disease states. Pharmaceutical compositions are proposed for the compounds.
    Type: Grant
    Filed: July 5, 1994
    Date of Patent: May 27, 1997
    Assignee: Berlex Laboratories, Inc.
    Inventors: Jerry L. Dallas, William J. Guilford, Sunil K. Koovakkat, Michael M. Morrissey, Kenneth J. Shaw
  • Polyamides bearing functionalized side chains useful as water soluble hypolipidemic agents
    Patent number: 5516758
    Abstract: This invention relates to derivatives of polyanhydroaspartic acid which are non-systemic water soluble polymers and which are intended to be lipid lowering agents. The pharmaceutical compositions/formulations incorporating these compounds are also discussed.
    Type: Grant
    Filed: December 23, 1993
    Date of Patent: May 14, 1996
    Assignee: Berlex Laboratories, Inc.
    Inventors: Kent R. Stevens, William V. Taggart
  • Inhibitors of the conversion of big endothelin to endothelin
    Patent number: 5504070
    Abstract: Novel and known compounds are described which inhibit endothelin converting enzyme (ECE), thereby preventing the conversion of Big Endothelin (BET) to Endothelin (ET). Pharmaceutical usefulness and preparations are described.
    Type: Grant
    Filed: December 5, 1991
    Date of Patent: April 2, 1996
    Assignee: Berlex Laboratories, Inc.
    Inventors: Ron H. Bihovsky, Paul W. Erhardt, John W. Lampe, Raju Mohan, Kenneth J. Shaw