Patents Represented by Attorney, Agent or Law Firm Dianne Casuto
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Patent number: 6063561Abstract: The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with --H, -Et, and/or --OH and the ethyl side-chain has been substituted with hydroxymethyl or dihydroxycyclohexylmethyl side-chains. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.Type: GrantFiled: May 13, 1998Date of Patent: May 16, 2000Assignee: Abbott LaboratoriesInventors: Leonard Katz, Diane L. Stassi, Richard G. Summers, Jr., Xiaoan Ruan, Ana Pereda-Lopez, Stephan J. Kakavas
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Patent number: 6060234Abstract: The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with --H, --Et, and/or --OH. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.Type: GrantFiled: May 16, 1997Date of Patent: May 9, 2000Assignee: Abbott LaboratoriesInventors: Leonard Katz, Diane L. Stassi, Richard G. Summers, Jr., Xiaoan Ruan, Ana Pereda-Lopez, Stephan J. Kakavas
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Patent number: 6057122Abstract: Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.Type: GrantFiled: May 5, 1997Date of Patent: May 2, 2000Assignee: Abbott LaboratoriesInventor: Donald J. Davidson
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Patent number: 6051374Abstract: Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.Type: GrantFiled: June 7, 1995Date of Patent: April 18, 2000Assignee: Abbott LaboratoriesInventors: John N. Simons, Tami J. Pilot-Matias, George J. Dawson, George G. Schlauder, Suresh M. Desai, Thomas P. Leary, Anthony Scott Muerhoff, James Carl Erker, Sheri L. Buijk, Isa K. Mushahwar
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Patent number: 6033898Abstract: An isolated DNA segment is disclosed which is derived from a Saccharomyces cerevisiae sorbitol dehydrogenase gene and which functions to increase expression of an associated foreign polypeptide when the DNA segment and the gene coding for the foreign polypeptide are operably linked in a vector in such a manner that the vector is replicated and carried by a host yeast cell. The functionally active portion of the segment is under the control (i) a transcriptional regulatory sequence of the sorbitol dehydrogenase gene of Saccharomyces cerevisiae, (ii) a translation initiation regulatory sequence of the sorbitol dehydrogenase gene of Saccharomyces cerevisiae, and (iii) a termination regulatory sequence of the sorbitol dehydrogenase gene of Saccharomyces cerevisiae. Yeast cells containing these regulatory sequences linked to a foreign DNA sequence are grown in medium containing sorbitol under conditions permitting a foreign polypeptide to be expressed.Type: GrantFiled: December 30, 1992Date of Patent: March 7, 2000Assignee: Abbott LaboratoriesInventors: Aparna V. Sarthy, Cynthia W. Schopp
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Patent number: 6022712Abstract: An isolated DNA segment is disclosed which is derived from a Saccharomyces cerevisiae sorbitol dehydrogenase gene and which functions to increase expression of an associated foreign polypeptide when the DNA segment and the gene coding for the foreign polypeptide are operably linked in a vector in such a manner that the vector is replicated and carried by a host yeast cell. The functionally active portion of the segment is under the control (i) a transcriptional regulatory sequence of the sorbitol dehydrogenase gene of Saccharomyces cerevisiae, (ii) a translation initiation regulatory sequence of the sorbitol dehydrogenase gene of Saccharomyces cerevisiae, and (iii) a termination regulatory sequence of the sorbitol dehydrogenase gene of Saccharomyces cerevisiae. Yeast cells containing these regulatory sequences linked to a foreign DNA sequence are grown in medium containing sorbitol under conditions permitting a foreign polypeptide to be expressed.Type: GrantFiled: June 6, 1995Date of Patent: February 8, 2000Assignee: Abbott LaboratoriesInventors: Aparna V. Sarthy, Cynthia W. Schopp
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Patent number: 6004787Abstract: A method to produce novel polyketide structures by designing and introducing specified changes in the DNA governing the synthesis of the polyketide is disclosed. The biosynthesis of specific polyketide analogs is accomplished by genetic manipulation of a polyketide-producing microorganism by isolating a polyketide biosynthetic gene-containing DNA sequence, identifying enzymatic activities associated within the DNA sequence, introducing one or more specified changes into the DNA sequence which codes for one of the enzymatic activities which results in an altered DNA sequence, introducing the altered DNA sequence into the polyketide-producing microorganism to replace the original sequence, growing a culture of the altered microorganism under conditions suitable for the formation of the specific polyketide analog, and isolating the specific polyketide analog from the culture.Type: GrantFiled: May 11, 1995Date of Patent: December 21, 1999Assignee: Abbott LaboratoriesInventors: Leonard Katz, Stefano Donadio, James B. McAlpine
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Patent number: 5981484Abstract: Mammalian kringle 5 peptide fragments are disclosed for treating angiogenic diseases Methods and compositions for inhibiting angiogenic diseases are also disclosed.Type: GrantFiled: April 3, 1997Date of Patent: November 9, 1999Assignee: Abbott LaboratoriesInventor: Donald J. Davidson
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Patent number: 5981172Abstract: Hepatitus GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and theraeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.Type: GrantFiled: April 6, 1995Date of Patent: November 9, 1999Assignee: Abbott LaboratoriesInventors: John N. Simons, Tami J. Pilot-Matias, George J. Dawson, George G. Schlauder, Suresh M. Desai, Thomas P. Leary, Anthony Scott Muerhoff, Sheri L. Buijk, James Carl Erker, Isa K. Mushahwar
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Patent number: 5972896Abstract: Mammalian kringle 5 fragments are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.Type: GrantFiled: August 11, 1998Date of Patent: October 26, 1999Assignee: Abbott LaboratoriesInventor: Donald J. Davidson
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Patent number: 5955318Abstract: Reagents and composition for controlling the translation of hepatitis GB virus (HGBV)-A, -B or -C peptides from viral nucleic acid. These reagents and methods comprise control elements of the 5' NTR region of the HGBV-A, -B, or -C viral genome.Type: GrantFiled: April 19, 1996Date of Patent: September 21, 1999Assignee: Abbott LaboratoriesInventors: John N. Simons, Suresh M. Desai, Isa K. Mushahwar
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Patent number: 5925512Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.Type: GrantFiled: May 23, 1995Date of Patent: July 20, 1999Assignee: Abbott LaboratoriesInventors: William F. Carman, Richard H. Decker, Lesley Wallace, Larry T. Mimms, Larry R. Solomon
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Patent number: 5905068Abstract: A compound of the formula: ##STR1## is disclosed as a retroviral protease inhibitor compound. Also disclosed are methods and compositions for inhibiting an HIV infection.Type: GrantFiled: September 24, 1996Date of Patent: May 18, 1999Assignee: Abbott LaboratoriesInventors: Xiaoqi Chen, Brian E. Green, Dale J. Kempf, Lin Li, Daniel W. Norbeck, Hing L. Sham
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Patent number: 5895750Abstract: A biotin-antibiotin immunoassay comprises coating a solid phase with a ligand-specific binding material, reacting the solid phase with a test sample, reacting the solid phase with the biotin-labeled form of the ligand-specific binding material and antibiotin labeled with a suitable marker. The marker is then measured to detect the amount of ligand present in the test sample.Type: GrantFiled: May 3, 1995Date of Patent: April 20, 1999Assignee: Abbott LaboratoriesInventors: Isa K. Mushahwar, Richard H. Decker, Karen V. Stuckmann
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Patent number: 5879900Abstract: A method for the simultaneous and quantitative, flow cytometric analysis of nucleated red blood cells (NRBC), white blood cells (WBC), damaged white blood cells and a white blood cell subclass differential (WBC/Diff) is provided.Type: GrantFiled: May 5, 1997Date of Patent: March 9, 1999Assignee: Abbott LaboratoriesInventors: Young Ran Kim, Michael W. Yee, Suresh N. Mehta, Josefino C. Sagala
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Patent number: 5858790Abstract: Hematology reference control cells and method of manufacture. The invention relates to the methods of preparing stable white blood cell ("WBC") and nucleated red blood cell ("NRBC") fractions and the hematology control reagents containing such stablized cells for primary use on a multi-angle light scatter based hematology instrument.Type: GrantFiled: June 26, 1996Date of Patent: January 12, 1999Assignee: Abbott LaboratoriesInventors: Young Ran Kim, Jean Emiko Kihara
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Patent number: 5843450Abstract: Hepatitis GB Virus (HGBV) synthetic peptides useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV peptides.Type: GrantFiled: June 7, 1995Date of Patent: December 1, 1998Assignee: Abbott LaboratoriesInventors: George J. Dawson, Tami J. Pilot-Matias, Dominique P. Bridon, Pamella A. Schroeder-Poliak, Mark F. Knigge, Keeve D. Jaffe, Isa K. Mushahwar
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Patent number: 5824513Abstract: A method to produce novel polyketide structures by designing and introducing specified changes in the DNA governing the synthesis of the polyketide is disclosed. The biosynthesis of specific polyketide analogs is accomplished by genetic manipulation of a polyketide-producing microorganism by isolating a polyketide biosynthetic gene-containing DNA sequence, identifying enzymatic activities associated within the DNA sequence, introducing one or more specified changes into the DNA sequence which codes for one of the enzymatic activities which results in an altered DNA sequence, introducing the altered DNA sequence into the polyketide-producing microorganism to replace the original sequence, growing a culture of the altered microorganism under conditions suitable for the formation of the specific polyketide analog, and isolating the specific polyketide analog from the culture.Type: GrantFiled: January 17, 1991Date of Patent: October 20, 1998Assignee: Abbott LaboratoriesInventors: Leonard Katz, Stefano Donadio, James B. McAlpine
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Patent number: 5807670Abstract: HGBV-C oligonucleotides from the 5' end of HGBV-C useful for the detection and genotyping of HGBV-C isolates. Also provided are assays which utilize these oligonucleotides.Type: GrantFiled: December 21, 1995Date of Patent: September 15, 1998Assignee: Abbott LaboratoriesInventors: Anthony Scott Muerhoff, John N. Simons, Thomas P. Leary, Larry Birkenmeyer, James C. Erker, Michelle Chalmers, George J. Dawson, Suresh M. Desai, Isa K. Mushahwar
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Patent number: 5801146Abstract: Mammalian kringle 5 is disclosed as a compound for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.Type: GrantFiled: May 3, 1996Date of Patent: September 1, 1998Assignee: Abbott LaboratoriesInventor: Donald J. Davidson