Patents Represented by Attorney, Agent or Law Firm Dianne Pecoraro
  • Device for mitigating odor in an article of clothing or footwear
    Patent number: 8336145
    Abstract: A deodorizer in particular, a deodorizer substrate with a porous carrier material formed in a monolithic form, and an odor neutralizing composition in the porous carrier material.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: December 25, 2012
    Assignee: MSD Consumer Care, Inc.
    Inventors: Gerald R. Dever, Harold A. Howlett, Philip C. Yang
  • Photostabilization of octyl triazone
    Patent number: 8303940
    Abstract: Methods and compositions useful in enhancing protection from UV radiation, the compositions containing octyl triazone and diethylthexyl syringylidene malonate in an amount effective to photostabilize octyl triazone.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: November 6, 2012
    Assignee: MSD Consumer Care, Inc.
    Inventors: Donathan G. Beasley, Thomas A. Meyer
  • Niacin receptor agonists, compositions containing such compounds and methods of treatment
    Patent number: 8168649
    Abstract: The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: May 1, 2012
    Assignee: Merk Sharp & Dohme Corp.
    Inventors: Subharekha Raghavan, Steven L. Colletti, Fa-Xiang Ding, Hong Shen, James R. Tata, Ashley Rouse Lins, Abigail Lee Smenton, Weichun Chen, Darby Rye Schmidt, George Scott Tria
  • Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles
    Patent number: 8168799
    Abstract: A process for the preparation of a compound of formula (I), or a salt, hydrate or solvate thereof; wherein R1 and R2 are each independently hydrogen, or C1-6 alkyl groups or R1 and R2 are linked and, together with the cyclopentane carbon atoms to which they are attached, form a cyclopropyl ring.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: May 1, 2012
    Assignee: Merck Sharpe & Dohme Ltd.
    Inventors: Michael Stewart Ashwood, Matthew Bio, Edward Cleator, David Hands, Faye Julia Sheen, Robert Darrin Wilson
  • Mineralocorticoid receptor modulators
    Patent number: 8063090
    Abstract: The present invention relates to diphenylmethyl imidazole mineralocorticoid receptor modulators compounds having the structure and their use in treating cardiovascular events.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: November 22, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Philip E. Brandish, James C. Hershey, Mark E. Fraley, Justin T. Steen
  • Process for the preparation of bicyclo[3.1.0]hexanols
    Patent number: 7834222
    Abstract: A process for the preparation of a the formula (I): which process comprises the intramolecular cyclopropanation of an epoxide of me formula (II); in the presence of 0.05 to 0.75 equivalents of a secondary amine base and at least one equivalent of an alkyl lithium base, wherein R R1, R2 and R3 are each hydrogen or C1-4 alkyl or R1 and R2 are linked to form- a C3-7 cycloaUcyl or C3-7 cycloalkenyl ring.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: November 16, 2010
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Matthew Bio, Karel Marie Joseph Brands, Edward Cleator
  • Anti-hypercholesterolemic compounds
    Patent number: 7696177
    Abstract: This invention provides cholesterol absorption inhibitors of Formula (I), and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: April 13, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Robert J. DeVita, Greg J. Morriello, Anthony K. Ogawa, Feroze Ujjainwalla
  • Inhibitors of prenyl-protein transferase
    Patent number: 6284755
    Abstract: The present invention is directed to azepan-2-one compounds which inhibit prenyl-protein transferase, particularly farnesyl-protein transferase (Ftase), and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: September 4, 2001
    Assignee: Merck & Co., Inc.
    Inventors: S. Jane deSolms, Samuel L. Graham, Anthony W. Shaw, Terrence M. Ciccarone, Gerald E. Stokker
  • Conjugates useful in the treatment of prostate cancer
    Patent number: 6174858
    Abstract: Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: January 16, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Stephen F. Brady, Dong-Mei Feng, Victor M. Garsky
  • Inhibitors of prenyl-protein transferase
    Patent number: 6172076
    Abstract: The present invention is directed to conformationally constrained compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: January 9, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Mark W. Embrey, John S. Wai, Debra S. Perlow, Jacob M. Hoffman
  • Process for the synthesis of substituted piperazinones via Mitsunobu reaction
    Patent number: 6160118
    Abstract: The present invention is directed to a process for synthesizing substituted piperazinones, which are useful intermediates for making farnesyl-protein transferase inhibitors, using a Mitsunobu reaction.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: December 12, 2000
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Stephanie Lewis, Steven A. Weissman
  • Process for making 1,5-disubstituted imidazoles
    Patent number: 6140508
    Abstract: The present invention is directed to a process for synthesizing 1,5-disubstituted imidazoles, which are useful in the preparation of farnesyl-protein transferase inhibitors.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: October 31, 2000
    Assignee: Merck & Co., inc.
    Inventors: David Askin, Jennifer A. Cowen, Peter E. Maligres, J. Christopher McWilliams, Marjorie S. Waters
  • Tablet dispensing cap
    Patent number: 6112942
    Abstract: A tablet dispensing cap that allows an individual who is elderly, infirm, handicapped or visually impaired to dispense a single, non-liquid form through a single-handed operation.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: September 5, 2000
    Assignee: Merck & Co., Inc.
    Inventor: Gordon D. Deacon
  • Inhibitors of farnesyl-protein transferase
    Patent number: 6103723
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: August 15, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Jeffrey M. Bergman, Christopher J. Dinsmore, Samuel L. Graham
  • Inhibitors of farnesyl-protein transferase
    Patent number: 6090948
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods of inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: July 18, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Christopher J. Dinsmore, George D. Hartman
  • Inhibitors of farnesyl-protein transferase
    Patent number: 6066738
    Abstract: The present invention is directed to compounds which inhibit farnesyl -protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: May 23, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Christopher J. Dinsmore, George D. Hartman
  • Radiolabeled farnesyl-protein transferase inhibitors
    Patent number: 6060038
    Abstract: The present invention is directed toward radiolabeled farnesyl-protein transferase inhibitor compounds which are useful to label FPTase in assays, whether cell-based, tissue-based or in whole animal. The tracers can also be used in competitive binding assays to obtain information on the interaction of unlabeled FTIs with FPTase.
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: May 9, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Hugh D. Burns, Wai-Si Eng, Raymond E. Gibson
  • Inhibitors of farnesyl-protein transferase
    Patent number: 6054466
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: November 18, 1998
    Date of Patent: April 25, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Terrence M. Ciccarone, S. Jane deSolms
  • Bottle
    Patent number: D670566
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: November 13, 2012
    Inventors: Jacob Teitelbaum, Scott Jost, Lee D. Stouch, Robert C. Johnson, Carolyn A. DeMaere
  • Bottle
    Patent number: D671414
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: November 27, 2012
    Assignee: MSD Consumer Care, Inc.
    Inventors: Jacob Teitelbaum, Scott Jost, Lee D. Stouch, Robert C. Johnson, Carolyn A. DeMaere