Patents Represented by Attorney Dilworth Paxson LLP
  • Patent number: 6362175
    Abstract: Methods and compounds for the measurement in vivo of oxygen in living tissue. The compounds preferably comprise a substituted porphyrin which is soluble in aqueous solution which is capable of absorbing an amount of energy and subsequently releasing the energy as phosphorescent light. In preferred embodiments, the porphyrin has an absorption band which is at a wavelength in the near infra-red window of living tissue and the phosphorescence is quenched by molecular oxygen according to the Stern-Volmer relationship.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: March 26, 2002
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Sergei Vinogradov, David F. Wilson
  • Patent number: 6355778
    Abstract: The present invention is directed to amino acid sequences for ethylene insensitive, EIN loci in the ethylene response in plant systems.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: March 12, 2002
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Joseph Ecker, Jose Alonso
  • Patent number: 6303290
    Abstract: The present invention provides a process for the encapsulation of biologically important proteins into transparent, porous silica matrices by an alcohol-free, aqueous, colloidal sol-gel process, and to the biological materials encapsulated thereby. The process is exemplified by studies involving encapsulated cytochrome c, catalase, myoglobin, and hemoglobin, although non-proteinaceous biomaterials, such as active DNA or RNA fragments, cells or even tissues, may also be encapsulated in accordance with the present methods. Conformation, and hence activity of the biomaterial, is successfully retained after encapsulation as demonstrated by optical characterization of the molecules, even after long-term storage. The retained conformation of the biomaterial is strongly correlated to both the rate of gelation and the subsequent drying speed of the encapsulatng matrix.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: October 16, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Dean-Mo Liu, I-Wei Chen
  • Patent number: 6298333
    Abstract: A computer system and method for a lessor to determine correct use tax on moveable equipment which may be subject to tax by more than one tax authority comprising inventory records for each individual item of equipment comprising an equipment identifier, equipment category, acquisition cost, depreciation, net book value, and branch; updating the inventory records to reflect each modification, improvement, disposition, and change in equipment category, and use tax paid; activity records comprising each lease event pertaining to each item of equipment; and a set of tax rules, which are periodically updated, for each taxing authority where any of the items of equipment may be leased or used, comprising sets of formulas reflecting relationships between tax due and acquisition of equipment, first leasing of equipment, subsequent leasing of equipment, length of lease term, age of equipment, and/or equipment categories.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: October 2, 2001
    Assignee: Transport International Pool, Inc.
    Inventors: Sharon Ann Manzi, Raju S. Kakarlapudi
  • Patent number: 6280425
    Abstract: An external catheter for attachment to the urethra is disclosed which includes a flow tube having a first and second end, the flow tube at the first end being funnel shaped, a spongy covering attached to the funnel shaped end for sealing an area around the urethra, said spongy covering being shaped so as to conform to the area surrounding the urethra, a skin adhesive for securing the spongy covering to the area surrounding the urethra and a fluid collector connected to said second end of said flow tube.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: August 28, 2001
    Inventor: Edmund Del Guercio
  • Patent number: 6274086
    Abstract: A detection device for three-dimensional tissue oxygen measurement in animals and humans comprising an array of fiber optics effective for transmitting emitted phosphorescent light, and further comprising an array of phosphorescent detectors and an excitation light emitter, forming a matrix and effective for sequential introduction of pulses of excitation light from a plurality of sites in said matrix.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: August 14, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David F. Wilson, Sergei A. Vinogradov
  • Patent number: 6219674
    Abstract: Systems and methods for creating and using product data to enhance the safety of a medical or non-medical products. The systems receive vast amounts of data regarding adverse events associated with a particular product and analyze the data in light of already known adverse events associated with the product. The system develops at least one proprietary database of newly discovered adverse event information and new uses for the product and may catalog adverse event information for a large number of population sub-groups. The system may also be programmed to incorporate the information into intellectual property and contract documents. Manufacturers can include the information in consumer product information which they provide to consumers or, in the case of certain medical products, prescribers of the medical products.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: April 17, 2001
    Assignee: Classen Immunotherapies, Inc.
    Inventor: John Barthelow Classen
  • Patent number: 6165741
    Abstract: This invention provides a method for growth detection and identification of microorganisms in a culture medium comprising providing a culture medium comprising a solubilized oxygen-quenchable phosphorescent compound, inoculating said culture medium with a substrate suspected of being associated with one or more microorganism, and detecting microorganism growth and identifying said microorganism by causing said phosphorescent compound to phosphoresce and observing quenching of oxygen in said culture of said compound.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: December 26, 2000
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David F. Wilson, Sergei A. Vinogradov
  • Patent number: 6166290
    Abstract: The invention includes an isolated DNA encoding a plant GS-X pump polypeptide and an isolated preparation of a plant GS-X pump polypeptide. Also included is an isolated preparation of a nucleic acid which is antisense in orientation to a portion or all of a plant GS-X pump gene. The invention also includes a cells, vectors and transgenic plants having an isolated DNA encoding a plant GS-X pump and methods of use thereof. In addition, the invention relates to plant GS-X pump promoter sequences and the uses thereof.
    Type: Grant
    Filed: November 18, 1997
    Date of Patent: December 26, 2000
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Philip A. Rea, Yu-Ping Lu, Ze-Sheng Li
  • Patent number: 6064710
    Abstract: Apparatus suitable for transporting and storing nuclear fuel rods comprising a basket having storage cells formed from a honeycomb gridwork of metal plates in a rectilinear configuration, the plates welded to each other at their intersections so that all contiguous corners of the storage cells formed by the gridwork are completely connected so as to allow conduction heat transfer, the metal plates having neutron absorber material positioned in areas which form walls of the storage cells.
    Type: Grant
    Filed: January 27, 1999
    Date of Patent: May 16, 2000
    Inventor: Krishna P. Singh