Abstract: An arterial needle removes blood from the access to an extracorporeal circuit comprising a dialyzer and a venous needle returns the blood to the access site. Blood passes along one side of the membrane of the dialyzer and dialysis fluid along the other side. The concentration (Cd norm and Cd rev) of urea in the dialysate emitted from the dialyzer is measured with the needles in the normal position and in a reversed position. The access flow rate before the arterial needle is calculated according to the formula: Cd norm/Cd rev=1+Keff/Qa in which Keff is the effective clearance of the dialyzer and Qa is the access flow rate.

Abstract: A centrifuge with an associated container system in the form of cassettes for separation and treatment of blood or blood components has been developed. The centrifuge includes a rotor having a central compartment in the form of a tubular shaft cavity extending concentrically with the axis of rotation of the rotor and an annular separation compartment which is arranged around the cavity at the upper part thereof. A first container system is arranged in the rotor, for washing of blood cells, includes a round bag and two or more flexible secondary containers connected thereto, one of which contains a treatment liquid and a tubular sleeve adapted to the shaft cavity of the rotor. The secondary containers are arranged in the sleeve to rest against each other and the round bag is mounted on a projecting flange at the upper part of the sleeve.

Abstract: A centrifuge intended for processing blood and blood components of use with a ring type blood processing bag with associated secondary bags. The rotor of the centrifuge has supports arranged along its periphery and a rotating inner lid a clamp function that secures the ring bag along and between supports. The supports can also function as valves or a welding apparatus for the tubing between the processing bag and the associated secondary bags.

Abstract: A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.

Abstract: Method and apparatus for quantitatively determining a degree of recirculalion flow in a vessel of a fluid by altering the electrical conductivity of the fluid, sensing the difference in electromagnetic field after the fluid is altered, and integrating the sensed difference over a period of time including any time of potential recirculation of any altered conductivity fluid.

Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Abstract: Correction quantities are generated for yielding closer approximations of actual parameters. These are obtained by preliminarily subjecting parametric transducers to pre-selected parametric values and recording the measured values for each transducer in a data table for later use as or in correction quantities. An embodiment includes interpolation relative to data table values closest to the operationally measured parametric value and using the resulting interpolated value as a corrected parametric value. Such interpolations may be performed for two parametric transducers relative to two substances. The resulting corrected parametric values may then be subtracted to obtain a parametric difference. A further embodiment may include using correction quantities of a reference parametric transducer in interpolation calculations for the actual parametric transducers.

Abstract: A needle holding device having an elongated hollow body with first and second ends, the first end being substantially open for receiving a needle. The hollow body also has a locking member operably disposed therein or thereon. The locking member has an opening to receive and non-releasably hold a needle inserted therethrough. Preferably, the locking member has one or more protrusions directed inwardly toward said opening, the protrusions being adapted to engage a needle in a locking relationship when the needle is inserted through the opening in the locking member. Also preferably, the needle holding device has an elastomeric sealing member operably connected to the hollow body, the elastomeric sealing member also being disposed adjacent the first end of said hollow body. The elastomeric sealing member is adapted to admit and seal around a needle pierced therethrough.

Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Abstract: A filter having a substantially cylindrical or slightly tapered body design which has a plurality of elongated apertures formed therethrough. Each aperture is defined side to side by a pair of elongated, wedge-like rib members disposed one on each side of each aperture, and top to bottom by a pair of cross members which present a substantially square top side and an angularly declining bottom side. The end effect is a substantially rectangular entry aperture for fluid flow with the exception of the declining bottom side which promotes smooth, low resistance entry flow. The present invention is also directed to a method of manufacture of filters having the above-described characteristics. In particular, the preferred method involves an injection molding process in which a molten plastic (such as high-density polyethylene, HDPE) is injected into a two-part mold.

Abstract: A flow rate of a fluid flowing in a tube is quantitatively determined by altering the electrical conductivity of the fluid by injection of a bolus of saline. The electrical conductivity of the altered conductivity is measured over the time it takes the altered conductivity fluid to pass a conductivity measuring location. The measured conductivity is integrated over the time it takes to pass the conductivity measuring location. The integral is interpreted to determine the flow rate.

Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Abstract: An integrated CRRT method and apparatus incorporates steps and means for compensating for heat loss from blood in an extracorporeal circuit. A blood warmer is designed to engage and hold a disposable blood tube segment to transfer heat at a closely controlled temperature to blood flowing in the disposable blood tube segment. Another significant aspect of the present invention is a blood tube segment for engagement with the blood warmer is located in downstream of a dialyzer and upstream of a venous pressure monitor, an air bubble detector and a venous line clamp. The disposable blood tube segment may be selectively connected when heat loss compensation is required and left disconnected when heat loss compensation is not required.

Abstract: A centrifuge with an associated container system in the form of cassettes for separation and/or treatment of blood or blood components. The centrifuge comprises a rotor having a central compartment in the form of a tubular shaft cavity extending concentrically with the axis of rotation of the rotor and an annular separation compartment which is arranged around said cavity at the upper part thereof. A first container system arranged in the rotor for washing of blood cells comprises a round bag with two or more flexible secondary containers connected thereto, of which at least one contains a treatment liquid, and a tubular sleeve adapted to the shaft cavity of the rotor. The secondary containers stand in the sleeve resting against each other, and the round bag is mounted on a projecting flange at the upper part of the sleeve.

Abstract: A connector for use in a dialysis tubing set in which the venous and arterial tubing connector ends are integrally molded into a one break-apart connector, such that the connector ends may be easily broken apart to form two distinct connector ends. Prior to use in a dialysis procedure, the connector ends are separated into two distinct connector ends by a manual snap breakage of the coupled connector ends at a line of weakness or partially scored portion of the integrally molded break-apart connector. Once separated from each other through manual separation of the connector, each connector end is connected to respective ports on the same medical apparatus. In this invention, the connector ends themselves are preferably each made in the respective color that corresponds to the color of either of the respective ports on the medical device.