Abstract: Novel oligomers, and synthesis thereof, comprising one or more bi-, tri, or polycyclic nucleoside analogues are disclosed herein. The nucleoside analogues have a “locked” structure, termed Locked Nucleoside Analogues (LNA). LNA's exhibit highly desirable and useful properties. LNA's are capable of forming nucleobase specific duplexes and triplexes with single and double stranded nucleic acids. These complexes exhibit higher thermostability than the corresponding complexes formed with normal nucleic acids. The properties of LNA's allow for a wide range of uses such as diagnostic agents and therapeutic agents in a mammal suffering from or susceptible to, various diseases.

Abstract: A crash management system for implementation in a flywheel energy storage system (FESS) is provided. Implementation of such a system entails designing an FESS rim that is highly failure resistant, and designing the FESS such that if one, some, or even all of its components fail, they are physically prevented from accumulating and releasing enough energy to cause rim burst, thus leaving the rim intact and capable of safely remaining spinning even after one or more FESS component failures have occurred.

Abstract: Methods are provides methods are provided to prepare photoresist and organic antireflective coating composition with a filter having a mean pore size of less than about 0.4 microns. Photoresist compositions and antireflective coatings produced by such methods can provide manufactured microelectronic devices that have significantly reduced defects. Photoresist and antireflective compositions obtainable by such methods also are provided.

Abstract: The invention provides compositions and methods for the synergistic degradation of oligosaccharides by endoglucanases. The invention further provides recombinant host cells containing one or more genes encoding endoglucanses which are capable of the synergistic degradation of oligosaccharides. Preferred host cells of the invention are ethanologenic and capable of carrying out simultaneous saccharification and fermentation resulting in the production of ethanol from complex cellulose substrates.

Abstract: A delivery device for the delivery of an agent to the mouth, nose or other bodily site of a user. The delivery device includes an aerosol canister that is actuated to expel propellant, which captures and disperses the agent. In a preferred embodiment, the propellant captures and disperses the agent into the mouth or nose of a user, and inhalation by the user directs the agent to the lungs of the user. The delivery device is particularly suitable for the treatment of bronchial asthma, respiratory conditions and for the delivery of systemically absorbed agents.

Abstract: The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. In particular, the assay of the invention makes use of a cell that harbors a protein that is responsive to a cellular signal transduction pathway. The protein is operatively linked to a polypeptide which causes a detectable signal to be generated upon stimulation of the pathway, e.g., when a compound interacts with and modulates the activity of a cellular receptor or ion channel of the cell.

Abstract: An apparatus and method are disclosed for electromanipulation of at least one cell or cell-like structure having cell-like membranes, the method comprising the steps: (a) at least one cell or cell-like structure is transported from one or more sample containers located on a chip through microchannel(s) located on said chip into a chamber located on said chip, wherein said chamber contains electrode(s) connected to a voltage generator, wherein said microchannel provides a fluid contact between the sample containers, (b) said cell or cell-like structure(s) is placed close to said at least one electrode, and (c) an electrical field is applied and focused on said cell or cell-like structure(s), said electrical field being of a strength sufficient to obtain pore-formation or fusion of said at least one cell or cell-like structure with another cell or cell-like structure(s) present in said chamber.

Abstract: The invention involves generating and presenting, typically electronically, a number of design alternatives to persons who are participating in the design, selection, or market research exercise. The participants (referred to as “selectors”) transmit data indicative of their preferences among or between the presented design alternatives, and that data is used to derive a new generation of design alternatives or proposals. The new designs are generated through the use of a computer program exploiting a genetic or evolutionary computational technique. The process is repeated, typically for many iterations or cycles.

Abstract: The present invention is a method for calibrating the temperature of a cooking appliance. It has been discovered that the calibration can vary widely, depending on when during the heating cycle it is performed. In accordance with the principles of the invention, temperature calibration is judiciously performed only when the sensed temperature substantially tracks the actual or calibration temperature of the cooking medium, increasing both accuracy and consistency. Such tracking has been found to occur after the sensed temperature is falling or rising form a detected peak or valley, respectively, while the gradient of the temperature profile is substantially constant.

Abstract: The present invention relates to novel semi-synthetic cyclosporin analogs for the prevention of organ transplantation rejection and the treatment of immune disorders and inflammation, their use as pharmaceuticals and pharmaceutical composition comprising them, as well as the processes for the their production. The present invention provides a cyclosporin compound of the following Formula (1) or its pharmaceutically acceptable salt, ester or prodrug thereof. In the compound of Formula (1), moiety “A” is Wherein “X” and “Y” are defined herein.

Abstract: A liquid crystal display device includes a display element with a pair of substrates, a liquid crystal layer between the substrates, and an alignment film on a surface of at least one substrate facing the layer; a pair of polarizers on both surfaces of the liquid crystal element to sandwich the liquid crystal element; and at least one optical phase element between at least one of the polarizers and the liquid crystal element, wherein an optical refractive ellipsoid of the optical phase element is tilted clockwise or counterclockwise from the normal of a surface of the optical phase element, wherein at least one of rates of variation of an ordinary refractive index and an extraordinary refractive index of a liquid crystal material of the liquid crystal layer with respect to a wavelength is set in a range where viewing angle dependent coloring does not occur on a screen.

Abstract: New methods are provided for synthesis of polysiloxanes (silsesquioxanes) and photoresists comprising same. Synthetic methods of the invention include use of a polymerization templating reagent that has multiple reactive nitrogen groups, particularly a diamine reagent.

Abstract: Highly efficient cationic liposomes have been developed as an improved delivery system for biologically-active reagents. A novel structure, the sandwich liposome, is formed and comprises one or more biologically active agents internalized between two bilomellar liposomes. This structure protects the incoming agent and accounts for the high efficiency of in vivo delivery and for the broad tissue distribution of the sandwich liposome complexes. These novel liposomes are also highly efficient carriers of nucleic acids. By using extruded DOTAP:cholesterol liposomes to form complexes with DNA encoding specific proteins, expression has been improved dramatically. Highest expression was achieved in the lung, while increased expression was detected in several organs and tissues.

Abstract: This invention relates to a novel metalloprotease having a proteolytic activity, its partial peptide or a salt either of them, a DNA coding for the protein, a recombinant vector comprising the DNA, a transformant carrying the recombinant vector, a process for producing the protein, a pharmaceutical composition comprising the DNA, an antibody against the protein, a method for screening for a compound which activates or inhibits a proteolytic activity of the protein, a kit for screening for the compound, and a compound which activates or inhibits a proteolytic activity of the protein which is identified by the screening method or the kit. The DNA coding for the protein of the present invention can be used as a therapeutic and prophylactic composition for a variety of diseases including diabetic nephropathy, glomerulonephritis, pulmonary fibrosis, hepatolienal fibrosis, hepatocirrhosis, osteopetrosis and herniated disk.

Abstract: A device for the placement of sutures and for the purpose of approximating tissue includes an elongate body member, a suture deployment system, and a catch. Methods of placing sutures include inserting and deploying in a patient a device including an elongate body member, a suture deployment system, and a catch. The suture deployment system is disposed at a distal portion of the elongate body member, and includes a suture carrier having a sharpened distal end for tissue penetration and a notch for holding a formed suture tip. The catch is disposed on the elongate body member to receive and retain the formed suture tip.

Abstract: The present invention relates to a new method for the synthesis of purine LNA (Locked Nucleic Acid) analogues which provides a higher overall yield. The method comprising a regioselective 9-N purine glycosylation reaction followed by a one-pot nucleophilic aromatic substitution reaction of the 6-substituent in the purine ring and simultaneous nucleophile-induced intramolecular ring closure of the C-branched carbohydrate to form novel purine LNA analogues. The novel strategy is illustrated by the synthesis of the novel compound (1S,3R,4R,7S)-7-benzyloxy-1-methanesulfonylmethyl-3-(guanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane which is easily converted into (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-((2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane after isobutyryl protection of the 2-amino purine group and subsequent substitution of 1-methanesulfonyl with benzoate, debenzoylation and debenzylation.

Abstract: A multi-mode shutdown system in combination with a fuel metering unit of an engine to prevent normal fuel delivery during engine malfunction such as the engine overspeeding. The multi-mode shutdown system includes a shutdown solenoid capable of closing a pressurizing valve to prevent fuel flow to the engine for creating a shutdown mode of operation with no fuel flow to the engine. The multi-mode shutdown system also includes a minimum flow solenoid in fluid communication a source of fuel at a minimum flow rate for creating a minimum flow mode of operation with fuel provided to the engine at the minimal flow rate. In the minimum flow mode, the shutdown solenoid and minimum flow solenoid establish a flow path for the fuel to the engine manifold at the minimal flow rate. During normal operation, the fuel metering unit regulates the fuel flow to the engine.

Abstract: An RF active deflector is described for use with orthogonal frequency division multiplex signals. An input antenna receives an RF input signal and an output antenna transmits an RF signal on substantially the same frequency as the input signal. An amplification path between the input antenna and the output antenna provides substantially linear processing and includes a delay. Means responsive to the signal in the amplification path produce a plurality of control coefficients. A transversal filter receives the signal in the amplification path and, under control by the control coefficient, provides a modified signal. A combiner is provided for combining the modified signal with the signal in said amplification path so as to reduce the effect of the feedback.

Abstract: Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affinity and high selectivity to CRF1 receptors, including human CRF1 receptors. The invention thus includes methods for treatment of disorders and diseases associated with CRF1 receptors, including CNS-related disorders and diseases, particularly affective disorders and diseases, and acute and chronic neurological disorders and diseases.

Abstract: At a preceding stage of a PR-channel APP decoder out of two APP decoders constituting a turbo decoder is disposed a logarithmic-likelihood computing circuit that computes logarithmic likelihoods L(y?i|yi) of a reproduced signal y?i, which is soft information. At a succeeding stage of the PR-channel APP decoder, on the other hand, a likelihood-transform RLL demodulator and a likelihood-transform RLL modulator capable of treating logarithmic likelihood ratios, which are soft information, are disposed between this APP decoder and a convolutional-code APP decoder. Thus, both RLL demodulation and turbo decoding can be fulfilled, and a turbo decoding of high error-correcting capability can be used to reproduce channel data ai recorded on a recording medium. As a result, the recording density of the recording medium is enhanced.