Abstract: Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
Type:
Grant
Filed:
November 18, 2004
Date of Patent:
November 28, 2006
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Robert Steven Kania, Steven Lee Bender, Allen J. Borchardt, Stephan James Cripps, Ye Hua, Michael David Johnson, Theodore Otto Johnson, Jr., Hiep The Luu, Cynthia Louise Palmer, Siegfried Heinz Reich, Anna Maria Tempczyk-Russell, Min Teng, Christine Thomas, Michael David Varney, Michael Brennan Wallace, Michael Raymond Collins
Abstract: There is provided a pharmaceutical composition suitable for topical administration to an eye, the composition comprising (a) a pharmacologically effective concentration of an active agent and (b) a combination of at least two ophthalmically compatible polymers comprising a novel gum system. In preferred embodiments of the present invention, the compositions increase the retention time of the active agent in the eye, when compared to compositions with other gums or gum systems.
Type:
Grant
Filed:
February 20, 2003
Date of Patent:
October 31, 2006
Assignee:
Pharmacia Corporation
Inventors:
Satish K. Singh, Paramita Bandyopadhyay
Abstract: A dispensing apparatus for a liquid product, the apparatus comprising a) a housing (2) or frame (3), b) a receptacle (4) for the liquid with a feed nozzle (4a) arranged substantially stationary with respect to the housing or frame, c) a dosing chamber (11) having an orifice (11a), d) a mechanism arranged to allow at least ejection of liquid through the orifice and e) a through passage (7) arranged to allow the ejected liquid to pass in a direction different from the feed nozzle or opening.
Type:
Grant
Filed:
September 8, 2003
Date of Patent:
July 4, 2006
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Bohdan Pavlu, Hans Himbert, Christian Péclat, Emmanuel Gremion, Daniel Siegfried, Alain Saurer, Joel Fontannaz
Abstract: An eye fluid applicator comprising a) a hand grip part having a distal end and a proximal end, the distal end and the proximal end defining a axis therebetween and a distal direction and a proximal direction along said axis, b) a container, or a seat for a container, having a bottle part and a delivery orifice for delivery of a stream or drops, the orifice defining a fluid delivery axis and a fluid delivery direction, along said axis, from the bottle through the orifice, the container being arranged with its orifice closer to the proximal end than the distal end, and c) an eye cup part having a rim and a cavity, the rim defining a contact plane, a contact axis normal to said contact plane and a contact direction, along said contact axis, from the cavity towards the rim, the eye cup being arranged at the orifice and the proximal direction of the hand grip and the contact direction of the eye cup forming an acute angle therebetween.
Type:
Grant
Filed:
May 21, 2002
Date of Patent:
June 20, 2006
Assignee:
Agouron Pharmaceuticals , Inc.
Inventors:
Maria Benktzon, Henric Bjarke, Carl-Göran Crafoord, Hans Himbert, Stig Mannberg, Ann-Marie Svensson, Jonas Törnsten
Abstract: Indazole compounds that modulate and/or inhibit the ophthalmic diseases and the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating ophthalmic diseases and cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
Type:
Grant
Filed:
December 15, 2003
Date of Patent:
May 30, 2006
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Allen J. Borchardt, Robert Steven Kania, Cynthia L. Palmer
Abstract: The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
Type:
Grant
Filed:
March 9, 2004
Date of Patent:
May 16, 2006
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Michael Collins, Stephan Cripps, Judith Deal, Robert Steven Kania, Jihong Lou, Mingying He, Cynthia Louise Palmer, William Henry Romines, III, Ru Zhou
Abstract: This invention relates to a process for the synthesis of enantiomerically enriched (1S,4R) 1-acetoxy-4-hydroxycyclopent-2-ene of Formula I, a compound useful as an intermediate in the synthesis of prostaglandins and prostanoids.