Patents Represented by Attorney Edward McC. Roberts
  • Patent number: 6211240
    Abstract: Compounds of the formula I in which Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, Z is a group a) R1 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4-alkynyl, C3-C6cycloalkyl, phenyl which is unsubstituted or at most trisubstituted by halogen, C1-C4alkyl, C1-C4alkoxy, C1-C4alkylthio, or benzyl which is unsubstituted or at most trisubstituted in the aromatic ring in the same manner; or is cyclopropylmethyl, C1-C4haloalkyl, C2-C5alkoxyalkyl, cyanomethyl, CO—R6, OH, NH2, C1-C4alkylamine or C1-C4alkoxycarbonyl-C1-C2alkyl; X is oxygen, sulfur or NR5; R2 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, C(O)R6, OH or C1-C4alkoxy, NH2 or C1-C4alkylamine; R5 is hydrogen, C1-C4alkyl, C2-C4alkenyl or C2-C4alkynyl; R6 is hydrogen, C114 C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C3-C6cycloalkyl, C1-C4alkoxycarbonyl or phenyl which is unsubstituted or at most trisubstituted; and in which R3 and R4 independently of one another are h
    Type: Grant
    Filed: October 29, 1996
    Date of Patent: April 3, 2001
    Assignee: Novartis Corporation
    Inventor: René Zurflüh
  • Patent number: 5770758
    Abstract: Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compounds of the formulae I and III: X is halogen,n is 0,1,2 or 3;Z is CN, CO-A or CS-A,A is hydrogen, halogen, OR.sub.1, SR.sub.2 and N(R.sub.3)R.sub.4 ;R.sub.1 to R .sub.4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R.sub.3 and R.sub.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: June 23, 1998
    Assignee: Novartis Corporation
    Inventors: Walter Kunz, Beat Jau
  • Patent number: 5756426
    Abstract: Described herein are compounds of the formula I ##STR1## and the isomers thereof, in which either a) X is an N atom andY is OR.sub.11 or N(R.sub.12)R.sub.13, orb) X is CH andY is OR.sub.11,and in which furthermore:R.sub.11 is C.sub.1 -C.sub.4 alkyl;R.sub.12 and R.sub.13, independently, are hydrogen or C.sub.1 -C.sub.4 alkyl;A is an O atom or the group NR.sub.4 ; and whereinR.sub.1, R.sub.2 and R.sub.3 are as defined herein, are pesticidal active ingredients. They can be used for pest control, in particular as microbicides, insecticides and acaricides in agriculture, horticulture and in the hygiene sector.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: May 26, 1998
    Assignee: Novartis Corporation
    Inventors: Hugo Ziegler, Stephan Trah, Saleem Farooq, Rene Zurfluh
  • Patent number: 5728875
    Abstract: .alpha.-Amino acid amides of the formula I ##STR1## in which n is the number zero or one;R.sub.1 is C.sub.1 -C.sub.12 alkyl, which is unsubstituted or can be substituted by C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.3 -C.sub.8 cycloalkyl, cyano, C.sub.1 -C.sub.6 alkoxycarbonyl, C.sub.3 -C.sub.6 alkenyloxycarbonyl or C.sub.3 -C.sub.6 alkynyloxycarbonyl; C.sub.3 -C.sub.8 cycloalkyl; C.sub.2 -C.sub.12 alkenyl;C.sub.2 -C.sub.12 alkynyl; C.sub.1 -C.sub.12 halogenoalkyl or a group NR.sub.13 R.sub.14 ; in which R.sub.13 and R.sub.14 independently of one another are hydrogen or C.sub.1 -C.sub.6 alkyl or together are tetra- or pentamethylene;R.sub.2 and R.sub.3 independently of one another are hydrogen; C.sub.1 -C.sub.8 alkyl; C.sub.1 -C.sub.8 alkyl which is substituted by hydroxyl, C.sub.1 -C.sub.4 alkoxy, mercapto or C.sub.1 -C.sub.4 alkylthio; C.sub.3 -C.sub.8 alkenyl;C.sub.3 -C.sub.8 alkynyl; C.sub.3 -C.sub.8 cycloalkyl or C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.
    Type: Grant
    Filed: August 26, 1996
    Date of Patent: March 17, 1998
    Assignee: Novartis Corporation
    Inventor: Martin Zeller
  • Patent number: 5726343
    Abstract: Process for the preparation of 2-methoxyimino-2-arylacetic esters of formula (I) in which R is C.sub.1 -C.sub.12 alkyl, which comprises reacting an appropriately substituted boronic acid of general formula (II) or the trimeric form (lII) herein, which is in equilibrium with it, in the presence of a Pd catalyst, with a methoxyiminoacetic ester of formula (IV) in which R is C.sub.1 -C.sub.12 alkyl and X is a leaving group. According to a further process variant, in principle the groups which split off the two reactants may change places. The process can be applied not only to phenyl derivatives but also to larger ring systems (naphthyl, pyridyl, heterocycles).
    Type: Grant
    Filed: July 22, 1996
    Date of Patent: March 10, 1998
    Assignee: Novartis Corporation
    Inventors: Hugo Ziegler, Denis Neff, Wolfgang Stutz
  • Patent number: 5723491
    Abstract: If the R-enantiomer of metalaxyl, furalaxyl or benalaxyl is used, this results in a markedly increased biodegradability of these plant fungicides in the soil and a higher activity on the plants, as compared with the data of the racemic active ingredients. Fungicidal compositions exhibiting said improved properties comprise either of these fungicides with a content of R-enantiomer of more than 70 percent by weight based on the total amount of active ingredient.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: March 3, 1998
    Assignee: Novartis Corporation
    Inventors: Cosima Nuninger, John Edward Nicholas Goggin, Dino Sozzi, Holm Ellgehausen
  • Patent number: 5710124
    Abstract: A method for treating or preventing mastitis in cows is disclosed. The method contemplates the intramammary injection or dipping the teat with Gallidermin and/or Epidermin or one of their pharmaceutically acceptable acid salts. Gallidermin and/or Epidermin or one of their pharmaceutically acceptable acid salts can be administered prior to infection to effectively suppress the rate, severity, and duration of subsequent bacterial infection, or can be administered subsequent to infection to effectively treat mastitis.
    Type: Grant
    Filed: February 16, 1996
    Date of Patent: January 20, 1998
    Assignee: Novartis Corporation
    Inventors: John Edmondson Peel, Bruno Suri
  • Patent number: 5710314
    Abstract: Compounds of formula I ##STR1## and possible isomers and isomeric mixtures thereof, wherein a)X is CH.sub.2 F or CHF.sub.2 ;Y is CH andZ is OMe, orb)X is CH.sub.2 F or CHF.sub.2 ;Y is a nitrogen atom andZ is OMe or NHCH.sub.3,and wherein alsom is 0, 1, 2, 3, 4 or 5 andU represents identical or different substituents selected from halogen, cyano, nitro, C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkenyloxyiminomethyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkoxyiminomethyl, C.sub.1 -C.sub.2 haloalkyl, C.sub.1 -C.sub.2 haloalkoxy, unsubstituted or substituted phenyl, unsubstituted or substituted phenoxy and unsubstituted or substituted benzyl or represents substituents at two adjacent positions of the phenyl ring of formula I that define a fused hydrocarbon bridge so as to form a larger hydrocarbon ring having up to 14 carbon atoms, are suitable for controlling and preventing microorganisms, insects and Acarina on plants.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: January 20, 1998
    Assignee: Novartis Corporation
    Inventors: Albert Pfiffner, Stephan Trah
  • Patent number: 5679115
    Abstract: Process for dyeing or printing organic material, in particular fibre material which comprises applying dyes containing no polymerizable double bond together with at least one colorless cationic compound containing at least one polymerizable double bond and, if desired, one or more colorless nonionic compounds containing at least one polymerizable double bond and, if desired, further auxiliaries to the fibre material and then fixing them by means of ionizing radiation, or applying dyes containing no polymerizable double bond together with at least one colorless cationic compound containing one polymerizable double bond, and if desired, one or more colorless nonionic compounds containing at least one polymerizable double bond and at least one photoinitiator and also, if desired, further auxiliaries to the fibre material and then fixing them by means of UV light.
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: October 21, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Katharina Fritzsche, Peter Aeschlimann, Peter Scheibli
  • Patent number: 5665840
    Abstract: The present invention describes a water-soluble crosslinkable prepolymer that comprises, in the copolymer chain, units derived from the following monomeric structural units: a vinyl lactam (a), vinyl alcohol (b), optionally a lower alkanecarboxylic acid vinyl ester (c), a vinylic crosslinking agent (d) and optionally a vinylic photoinitiator (e); a process for the preparation of the novel prepolymers; crosslinked water-insoluble polymeric networks therefrom; hydrogels and moulded articles made from the crosslinked water-insoluble polymeric networks, especially contact lenses; and a process for the manufacture of hydrogels and finished contact lenses using the mentioned crosslinkable water-soluble prepolymers.
    Type: Grant
    Filed: November 3, 1995
    Date of Patent: September 9, 1997
    Assignee: Novartis Corporation
    Inventors: Thomas Pohlmann, Achim Muller, Bernhard Seiferling
  • Patent number: 5663453
    Abstract: Compounds of the formula ##STR1## in which: n is 0, 1 or 2, and, if n is 2, the two radicals R.sub.3 are identical or different;R.sub.2 is methyl, fluorine, chlorine or bromine;R.sub.3 is C.sub.1 -C.sub.3 -alkyl, halo-C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, halo-C.sub.1 -C.sub.3 alkoxy, fluorine, chlorine or bromine:R.sub.5 is hydrogen or C.sub.1 -C.sub.9 alkyl andX is methylene, O, S or C(.dbd.O):can be used as intermediates for agrochemical active ingredients.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: September 2, 1997
    Assignee: Ciba-Geiby Corporation
    Inventor: Friedrich Karrer
  • Patent number: 5663176
    Abstract: Mixtures of certain triazole fungicides (component I) and 4,6-dimethyl-N-phenyl-2-pyrimidinamine (component II) achieve synergistically enhanced activity against fungus infestation. Components I and II can also be applied to plant crops individually, one immediately after the other.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: September 2, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Adolf Hubele, Ronald Zeun
  • Patent number: 5650517
    Abstract: 2,3-Difluoro-5-halopyridines of the formula I ##STR1## wherein X is Cl or Br are prepared by a process which comprises reacting a starting 2,3,5-trihalopyridine of the formula II ##STR2## wherein each X is individually Br or Cl and Y is F, Cl or Br with an effective amount of potassium fluoride in the presence of a mixture of sulfolane and a tetralkylurea and/or a dialkyl-alkyleneurea as diluent, at an effective temperature up to the boiling point of the diluent, optionally in the presence of a phase-transfer catalyst such as a crown ether or polyglycol ether. The compounds are useful as intermediates to prepare herbicides.
    Type: Grant
    Filed: November 1, 1994
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Balakrishnan Venugopal
  • Patent number: 5648383
    Abstract: When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly increased fungicidal action against plant diseases as compared with a similar mixture in which metalaxyl is used in the form of the racemate.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 15, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Cosima Nuninger, John Edward Nicholas Goggin, Dino Sozzi
  • Patent number: 5645169
    Abstract: A package containing water-soluble bags filled with agricultural chemicals in gel or liquid form facilitates the transport of the bags in a manner which prevents the breakage thereof. The package includes compartments for holding the bags. The walls and base of these compartments contain raised and unraised portions in a pattern such that a baffling effect is created to damper transport shock waves in the gel or liquid bag. These and other features result in the transmission of dynamic shock loads in the package in a manner which prevents such shock loads from breaking the fragile water-soluble bags during transport.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: July 8, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Lawrence Clifford Dull, Larry Arnold Simmons
  • Patent number: 5643360
    Abstract: An apparatus for a process for wet-treating seeds with an acaricidal, fungicidal, insecticidal or nutritive agent which consists of a foam-forming apparatus comprising a first foam-formation chamber equipped with openings which allow a gas and the aqueous composition containing at least one nonphytotoxic foaming agent to be admitted and containing, downstream of these openings, at least one sieve, this first chamber continuing into a second chamber for compressing and structuring the foam, which ends in an outlet nozzle for the foam.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: July 1, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Cornelis Willem Rensing, Hubert Sainsard
  • Patent number: 5627188
    Abstract: Mixtures of certain triazole fungicides (component I) and 4-cyclopropyl-6-methyl-N-phenyl-2-pyrimidinamine (component II) have a synergistically increased activity against fungus infestation. Components I and II can also be applied to crops individually in immediate succession.
    Type: Grant
    Filed: July 18, 1995
    Date of Patent: May 6, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Ludwig Mittermeier, Wilhelm Ruess
  • Patent number: 5621018
    Abstract: Compounds of formula I: ##STR1## are disclosed. The compounds are photoinitiators which can be functionalized by means of ethylenic groups or can be bonded to H-active substances, in order, for example, to modify surfaces by means of photopolymerizable substances. The compounds are especially useful in the manufacture of contact lenses.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 15, 1997
    Assignee: CIBA GEIGY Corporation
    Inventors: Peter Chabrecek, Dieter Lohmann
  • Patent number: D379714
    Type: Grant
    Filed: July 21, 1995
    Date of Patent: June 10, 1997
    Assignee: Ciba Geigy Corporation
    Inventors: David E. Cerny, Paul J. Mulhauser, Christopher J. Brooks
  • Patent number: D380898
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: July 15, 1997
    Inventor: Francis John Lovell