Abstract: A method for synthesizing an alkyl-2-one by reacting a 2-alkene halide with a 2,4-alkanedione in an alkylene glycol medium having a boiling point higher than said alkene-2-one is described.

Abstract: A method for the preparation of titanium-containing metallocene compounds, including constrained geometry titanium complexes, useful as olefin polymerization catalysts is disclosed. Pursuant to the invention, titanium tetrachloride is converted to titanium trichloride by reaction with a metal compound in a non-interfering solvent to produce a mixture useful directly for reaction with a deprotonated metallocene ligand. The titanocene compounds produced pursuant to the invention are free of trace amounts of aluminum which can adversely affect the polymerization reaction.

Abstract: Silyl amine compounds which have a proton available for covalent bonding to a metallocene metal center are disclosed.

Abstract: A method for producing an alkyl cyclopentadiene by reacting cyclopentadienyl Grignard with an alkyl halide and for converting the alkyl cyclopentadiene to a bis(n-alkyl cyclopentadienyl) Group IV metal dihalide is described.

Abstract: A method of converting Compound A (1,3-dehydro-cyclopenta[1]phenanthren-2-one) to Compound C (1H-cyclopenta[1]penanthren) in situ in a single reactor is disclosed.

Abstract: A cervical plate for use alone or in combination with a cervical link system is described. The cervical plate may be generally quadrangular with a bone screw aperture at each corner area. An oval or elongated bone screw aperture is positioned in the central area of the cervical plate to accommodate intercalation of a bone screw and consequent vertical positioning of the plate. The plate may be secured to at least one link of a cervical link system or used to facilitate revision surgery.

Abstract: Production of aryl cyclopentadienyl Group IVA metal dihalides by dehydrogenation of a substituted or unsubstituted bis-(cyclohexenylcyclopentadienyl) Group IVA metal dihalide is described.

Abstract: A process for preparing tetrakis (pentafluorophenyl) borate is described that involves reaction of a pentafluorophenyl magnesium halide with an alkali metal tetrafluoroborate.

Abstract: Novel silanes having the formula (RSO.sub.3).sub.2 --Si--Q.sub.2.0.5HX are described. Synthesis of silylated bis-cyclopentadienyl and N-silylated mono(cyclopentadienyl) ligands and similar indenyl ligands utilizing the novel silanes is described.

Abstract: Novel 2-substituted 7-haloindenes and methods for synthesizing such indents are described. The 2-substituted 7-haloindenes may be coupled with any aryl group to produce a metallocene catalyst intermediate.

Abstract: An apparatus, method and system for treating spinal conditions by moving or spatially fixing at least one vertebra relative to another vertebra. The invention includes a link member the ends of which are configured to be secured to adjacent vertebrae and which are offset from a central portion of the link member. The link members can be in the form of a C-shaped or V-shaped rod or plate to form the offset. The offset provides increased bone volume that can be used for grafts or fusion. Attachment structure in the form of bone screws, bolts, or hook members are provided to secure the link members to respective vertebrae or other bones. A plurality of link members can be connected in chain-like fashion to connect multiple points on a plurality of vertebrae or other bones even though those points are nonlinear. In another aspect of the invention, a multi-directional attachment member is provided and may be used with the link members to form a spinal implant or external bone fixation system.

Abstract: An apparatus, method and system for treating spinal conditions by moving or spatially fixing at least one vertebra relative to another vertebra. The invention includes a link member the ends of which are configured to be secured to adjacent vertebrae and which are offset from a central portion of the link member. The link members can be in the form of a C-shaped or V-shaped rod or plate to form the offset. The offset provides increased bone volume that can be used for grafts or fusion. Attachment structure in the form of bone screws, bolts, or hook members are provided to secure the link members to respective vertebrae or other bones. A plurality of link members can be connected in chain-like fashion to connect multiple points on a plurality of vertebrae or other bones even though those points are nonlinear. In another aspect of the invention, a multi-directional attachment member is provided and may be used with the link members to form a spinal implant or external bone fixation system.

Abstract: A practical and scalable process for the synthesis of constrained geometry metallocene catalyst is described.

Abstract: An apparatus, method and system for treating spinal conditions by moving or spatially fixing at least one vertebra relative to another vertebra. The invention includes a link member the ends of which are configured to be secured to adjacent vertebrae and which are offset from a central portion of the link member. The link members can be in the form of a C-shaped or V-shaped rod or plate to form the offset. The offset provides increased bone volume that can be used for grafts or fusion. Attachment structure in the form of bone screws, bolts, or hook members are provided to secure the link members to respective vertebrae or other bones. A plurality of link members can be connected in chain-like fashion to connect multiple points on a plurality of vertebrae or other bones even though those points are nonlinear. In another aspect of the invention, a multi-directional attachment member is provided and may be used with the link members to form a spinal implant or external bone fixation system.

Abstract: Improved hollow fiber bioreactor systems and cell culture methods are described. The improvement includes means which may be a novel basket bioreactor for extending the extracapillary space of a conventional hollow fiber bioreactor.

Abstract: A method for the synthesis of certain N-silylated cyclopentaphenanthrene (Group IV metal) complexes is disclosed.

Abstract: An anchor for immobilizing a spinal bone graft in position for fusion to adjacent vertebrae is described. The anchor may be used as a component of a spinal implant system as described in U.S. Pat. No. 5,716,357.

Abstract: A sensing device for capturing acoustic heart sounds has a diaphragm formed from a piezoelectric transducer material which generates excitation signals in response to acoustic and vibratory energy outputs. The sensing device includes metallization layers on the diaphragm for receiving and transmitting the excitation signals to an output display device via associated electrical contacts and electrical leads and also includes a layer of adhesive material for coupling the sensing device to the subject. The sensing device further includes snap connectors for allowing the device to be quickly disengaged from electrical leads and discarded. A patch sensor device is disclosed which enables acoustic outputs to be triangulated and pinpointed.

Abstract: An apparatus, method and system for treating spinal conditions by moving or spatially fixing at least one vertebra relative to another vertebra. The invention includes a link member the ends of which are configured to be secured to adjacent vertebrae and which are offset from a central portion of the link member. The link members can be in the form of a C-shaped or V-shaped rod or plate to form the offset. The offset provides increased bone volume that can be used for grafts or fusion. Attachment structure in the form of bone screws, bolts, or hook members are provided to secure the link members to respective vertebrae or other bones. A plurality of link members can be connected in chain-like fashion to connect multiple points on a plurality of vertebrae or other bones even though those points are nonlinear. In another aspect of the invention, a multi-directional attachment member is provided and may be used with the link members to form a spinal implant or external bone fixation system.

Abstract: A process and a system for cracking dicyclopentadiene are disclosed pursuant to the process preheated dicyclopentadiene is introduced into a heated transfer fluid sufficiently below the transfer fluid surface to accomplish substantially complete conversion of said dicyclopentadiene to monomeric cyclopentadiene vapor.