Patents Represented by Attorney, Agent or Law Firm Elaine Sale
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Patent number: 8236562Abstract: The invention relates to a method for producing ready to use, antigen loaded or unloaded, cryoconserved mature dendritic cells especially for the production of a vaccine containing said dendritic cells, wherein immature dendritic cells are cultivated in the presence of suitable maturation stimuli and the mature dendritic cells thus obtained are frozen. The dendritic cells can be loaded with antigen before freezing. The invention also relates to a vaccine which can be obtained according to the inventive method and to a composition containing frozen, mature dendritic cells which are loaded with antigen.Type: GrantFiled: August 24, 2001Date of Patent: August 7, 2012Assignee: Argos Therapeutics, Inc.Inventors: Gerold Schuler, Beatrice Schuler-Thurner
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Patent number: 7271316Abstract: A transgenic plant transformed by a phosphatase stress-related protein (PHSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated PHSRPs, and isolated nucleic acid coding PHSRPs, and vectors and host cells containing the latter.Type: GrantFiled: January 23, 2004Date of Patent: September 18, 2007Assignee: BASF Plant Science GmbHInventors: Oswaldo da Costa e Silva, Hans J. Bohnert, Nocha van Thielen, Ruoying Chen, Manabu Ishitani
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Patent number: 7259294Abstract: A transgenic plant transformed by a GTP Binding Stress-Related Protein (GBSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated GBSRPs, and isolated nucleic acid coding GBSRPs, and vectors and host cells containing the latter.Type: GrantFiled: October 17, 2003Date of Patent: August 21, 2007Assignee: BASF Plant Science GmbHInventors: Oswaldo da Costa e Silva, Hans J. Bohnert, Nocha van Thielen, Ruoying Chen
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Patent number: 7235713Abstract: A transgenic plant transformed by a potassium channel stress-related protein (PCSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated PCSRP, and isolated nucleic acid coding PCSRP, and vectors and host cells containing the latter. Further provided are methods of producing transgenic plants expressing PCSRP, methods of identifying novel PCSRP using antibodies, and methods of modifying the expression of PCSRP in plants.Type: GrantFiled: December 22, 2000Date of Patent: June 26, 2007Assignee: BASF Plant Science GmbHInventors: Manabu Ishitani, Ruoying Chen, Nocha van Thielen, Oswaldo da Costa e Silva
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Patent number: 7223903Abstract: A transgenic plant transformed by a protein kinase stress-related protein (PKSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated PKSRP, and isolated nucleic acid coding PKSRP, and vectors and host cells containing the latter. Further provided are methods of producing transgenic plants expressing PKSRP, and methods of identifying novel PKSRP and methods of modifying the expression of PKSRP in plants.Type: GrantFiled: December 22, 2000Date of Patent: May 29, 2007Inventors: Oswaldo da Costa e Silva, Manabu Ishitani, Stefan Henkes, Nocha van Thielen, Ruoying Chen
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Patent number: 7220896Abstract: A transgenic plant transformed by a pyrophosphatase stress-related protein (PPSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated PPSRP, and isolated nucleic acid coding PPSRP, and vectors and host cells containing the latter. Further provided are methods of producing transgenic plants expressing PPSRP, methods of identifying novel PPSRP, and methods of modifying the expression of PPSRP in plants.Type: GrantFiled: December 22, 2000Date of Patent: May 22, 2007Assignee: BASF Plant Science GmbHInventors: Stefan Henkes, Ruoying Chen, Nocha van Thielen, Oswaldo da Costa e Silva
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Patent number: 7220585Abstract: A transgenic plant transformed by a Transcription Factor Stress-Related Protein (TFSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated TFSRPs, and isolated nucleic acid coding TFSRPs, and vectors and host cells containing the latter.Type: GrantFiled: November 12, 2002Date of Patent: May 22, 2007Assignee: BASF Plant Science GmbHInventors: Ruoying Chen, Nocha Van Thielen, Oswaldo da Costa e Silva
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Patent number: 7198948Abstract: We describe an improved method for generating sizable numbers of mature dendritic cells from nonproliferating progenitors in human blood. The first step or “priming” phase is a culture of T cell depleted mononuclear cells in medium supplemented with GM-CSF and IL-4 to produce immature dendritic cells. The second step or “differentiation” phase requires the exposure to dendritic cell maturation factor such as monocyte conditioned medium. Using this two-step approach, substantial yields are obtained. The dendritic cells derive from this method have all the features of mature cells. They include a stellate cell shape, nonadherence to plastic, and very strong T cell stimulatory activity. The mature dendritic cells produced according to this invention are useful for activating T cells.Type: GrantFiled: January 15, 2002Date of Patent: April 3, 2007Assignees: The Rockefeller University, Argos Therapeutics, Inc.Inventors: Ralph M. Steinman, Nina Bhardwaj, Gerold Schuler
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Patent number: 7189893Abstract: A transgenic plant transformed by a Cell Cycle Stress-Related Protein (CCSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated CCSRPs, and isolated nucleic acid coding CCSRPs, and vectors and host cells containing the latter.Type: GrantFiled: January 30, 2004Date of Patent: March 13, 2007Assignee: BASF Plant Science GmbHInventors: Oswaldo da Costa e Silva, Hans J. Bohnert, Nocha van Thielen, Ruoying Chen, Rodrigo Sarria-Millan
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Patent number: 7179962Abstract: A transgenic plant transformed by a Protein Kinase Stress-Related Protein (PKSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated PKSRPs, and isolated nucleic acid coding PKSRPs, and vectors and host cells containing the latter.Type: GrantFiled: January 30, 2004Date of Patent: February 20, 2007Assignee: BASF Plant Science GmbHInventors: Oswaldo da Costa e Silva, Hans J. Bohnert, Nocha van Thielen, Ruoying Chen, Rodrigo Sarria-Millan
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Patent number: 7176026Abstract: A transgenic plant transformed by a Protein Kinase Stress-Related Polypeptide (PKSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated PKSRPs, and isolated nucleic acid coding PKSRPs, and vectors and host cells containing the latter.Type: GrantFiled: November 12, 2002Date of Patent: February 13, 2007Assignee: BASF Plant Science GmbHInventors: Nocha Van Thielen, Oswaldo da Costa e Silva, Ruoying Chen
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Patent number: 7166767Abstract: A transgenic plant transformed by a Signal Transduction Stress-Related Protein (STSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated STSRPs, and isolated nucleic acid coding STSRPs, and vectors and host cells containing the latter.Type: GrantFiled: February 2, 2004Date of Patent: January 23, 2007Assignee: BASF Plant Science GmbHInventors: Oswaldo da Costa e Silva, Hans J. Bohnert, Nocha van Thielen, Ruoying Chen, Manabu Ishitani
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Patent number: 7164057Abstract: A transgenic plant transformed by a transcription factor stress-related protein (TFSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated TFSRP, and isolated nucleic acid coding TFSRP, and vectors and host cells containing the latter. Further provided are methods of producing transgenic plants expressing TFSRP, methods of increasing expression of other genes of interest using the TFSRP, methods of identifying novel TFSRP, and methods of modifying the expression of TFSRP in plants.Type: GrantFiled: December 22, 2000Date of Patent: January 16, 2007Assignee: BASF Plant Science GmbHInventors: Oswaldo da Costa e Silva, Nocha van Thielen, Ruoying Chen
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Patent number: 7161063Abstract: A transgenic plant transformed by a Transcription Factor Stress-Related Protein (TFSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by the transgenic plants. Also provided are isolated TFSRPs, and isolated nucleic acid coding TFSRPs, and vectors and host cells containing the latter.Type: GrantFiled: November 18, 2003Date of Patent: January 9, 2007Assignee: BASF Plant Science GmbHInventors: Oswaldo da Costa e Silva, Hans J. Bohnert, Nocha van Thielen, Ruoying Chen
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Patent number: 7085690Abstract: The invention provides an automated method for identifying an optimal or near optimal mathematical model to describe observed data including: a) the definition of a candidate model search space, b) methods for searching said candidate model search space to identify the optimal or near optimal model within said candidate model search space. The present invention includes algorithms for writing the computer code needed to implement and evaluate candidate models in the software package NONMEM.Type: GrantFiled: June 11, 2001Date of Patent: August 1, 2006Inventor: Mark Edward Sale
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Patent number: 7034208Abstract: This invention is directed to a screening method for the selection of mutations which confer acetohydroxyacid synthase (AHAS) inhibiting herbicide resistance to wheat. After mutagenesis of wheat seeds, the seeds are soaked in an AHAS inhibiting herbicide-containing solution containing a particular class of AHAS inhibiting herbicide. After planting, the soil containing the seeds is sprayed with an AHAS inhibiting herbicide of the same class as that used in the seed soak step prior to the emergence of the seedlings from the soil. Those wheat seedlings which emerge and are normal in appearance demonstrate resistance to the class of AHAS inhibiting herbicides used in the seed soak and spraying steps. This invention is also directed to the wheat selections and seeds identified by the screening method.Type: GrantFiled: June 7, 1995Date of Patent: April 25, 2006Assignee: BASF AktiengellschaftInventor: Wendy A. Smith
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Patent number: 6355240Abstract: A method is described for enhancing the efficacy of recombinant insect viruses, such as baculoviruses and granulosis viruses, for use as insecticides. This invention relates to recombinant insect viruses and vectors for use therewith in which the expression of a heterologous gene or fragments thereof (preferably encoding an insect controlling substance or modifying substance, such as an insect toxin) is operably linked to an early promoter.Type: GrantFiled: July 25, 1996Date of Patent: March 12, 2002Assignee: BASF AktiengellschaftInventor: Peter M. Dierks
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Patent number: 6339184Abstract: This invention is directed to a screening method for the selection of mutations which confer acetohydroxyacid synthase (AHAS) inhibiting herbicide resistance to wheat. After mutagenesis of wheat seeds, the seeds are soaked in an AHAS inhibiting herbicide-containing solution containing a particular class of AHAS inhibiting herbicide. After planting, the soil containing the seeds is sprayed with an AHAS inhibiting herbicide of the same class as that used in the seed soak step prior to the emergence of the seedlings from the soil. Those wheat seedlings which emerge and are normal in appearance demonstrate resistance to the class of AHAS inhibiting herbicides used in the seed soak and spraying steps. This invention is also directed to the wheat selections and seeds identified by the screening method.Type: GrantFiled: March 25, 1994Date of Patent: January 15, 2002Assignee: BASF AktiengellschaftInventor: Wendy A. Smith