Abstract: The didemnin class of biologically active cyclodepsipeptides, isolated from the marine tunicate Trididemnun solidum, has shown considerable antitumor, antiviral, and immunosuppressive activities. Didemnin B (DB) and most other natural didemnins contain a common macrocycle and differ only in the composition of the side chain. In the present invention, structural modifications were introduced in the side chain to afford several didemnin analogues for structure-activity relationship studies. The latter have shown that the linear side chain portion of the didemnin core structure can be altered and, in some cases, provide significant gains in bioactivities. Of the compounds synthesized the new [Ala.sup.9 ] didemnin B is the most active against the L1210 (murine leukemia) cell line, at the 0.04 ng/mL level.

Abstract: The present invention is directed to the isolation and characterization of six new crambescidin compounds, the structures of which are shown below: ##STR1## .

Abstract: A new cyclic heptapeptide, trunkamide A, with antitumor activity has been isolated from a Lissoclinium sp. collected on the Great Barrier Reef, Australia.

Abstract: Kalahide F. of formula I below, may be isolated from a secoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions.

Abstract: An alignment aid for golfers consisting of a rigid hemispherically shaped body having two intersecting slits therein for making a mark on a golf ball which indicates the intended path of the golf ball and the preferred orientation of the club face for obtaining the intended path of the golf ball.

Abstract: Low foaming therapeutic toothpastes containing a therapeutic substance, an abrasive, a humectant, a low foam surfactant, and/or a foam control agent having improved cleaning and abrasion performance wherein: packing of the abrasive into the channels of a channeled bristle toothbrush, and abrasive/tooth surface contact, are substantially free from surfactant bubble interference such that Cleaning Efficiency Coefficient and Abrasion Efficiency Coefficient values greater than about 1.1 are achieved along with improvements in therapeutic efficacy.

Abstract: Five new nucleophile substituted ecteinascidin (Et) compounds have been isolated from extracts of Ecteinascidia turbinata. These compounds have been purified by chromatographic techniques and their structures and bioactivities have been determined. The five nucleophile substituted Et compounds have been designated herein as Et 802 (1), Et 788 (2), Et 760 (3), Et 858 (4) and Et 815 (5). Also obtained were three new N-oxide ecteinascidin compounds, which have been designated herein as Et 717 (6), Et 775 (7) and Et 789 (8). Some of these newly discovered Et compounds show exceedingly potent cytotoxicity against L1210.

Abstract: Disclosed is a composite note pad assembly which comprises two independent stacks of individual sheets, sandwiched together, wherein the resulting composite pad assembly has a fall writing surface on both the top and the bottom of the assembly. In this manner, unlike conventional pads, there is no bottom of the stack, and there is no exposed glue surface which would otherwise interfere with writing or marking the paper, or which would get covered with office dirt and grime. The two-part composite pad assembly is unique, because it has two exposed writing surfaces at all times. In a preferred embodiment, the papers used to make the two segments of the composite pad assembly are different, e.g., different color, different appearance, etc., allowing the user the option of having two choices of "note" from a single pad assembly.

Abstract: The present invention is directed to several novel compounds isolated from the sponge Crambe crambe, and designated herein as Crambescidin 816 (Compound 1), Crambescidin 830 (Compound 2), Crambescidin 844 (Compound 3), and Crambescidin 800 (Compound 4), as well as several derivatives thereof. The 816, 830, 844 and 800 compounds are four preferred species of complex pentacyclic guanidines linked by a linear .omega.-hydroxy fatty acid to a hydroxyspermidine, that have been obtained by a bioassay-guided isolation procedure, involving solvent partition and chromatography on Sephadex LH-20, cyano, and C-18 columns, from extracts of the red, encrusting sponge Crambe crambe (Order Poecilosclerida, Family Esperiopsidae).

Abstract: A portable filing and storage system having a unitary cover subdivided into a front flap, a top, a back, a bottom and a front; the cover being constructed and arranged to provide an open-sided surrounding enclosure. A media holder is mounted to the front portion of said cover, and an accordion file is mounted to the interior of the enclosure defined by said cover. The file system has a closed configuration wherein the front flap is in overlying relationship with said front portion of the cover, and an open configuration where the front flap is elevated from the front portion of said closure. A closure retainer for maintaining the file system in the closed configuration is provided.

Abstract: This invention relates generally to a solution for electroless deposition of gold, and more particularly to a cyanide-free electroless gold solution that can be replenished by the addition of a solution of a non-cyanide complex of gold. The operating temperature range for the plating solution of the present invention ranges from about 40.degree. to about 70.degree. C. The opportunity to deposit gold at such low operating temperatures is especially beneficial for plating devices which cannot withstand the higher temperatures required for existing electroless gold solutions. The relatively low operating temperatures also provide for significant energy savings and increased operator comfort and safety as compared to existing electroless gold solutions.