Abstract: A network linking device in communication with a computer host and an external network is disclosed. The network linking device includes a media access controller (MAC), a buffer and a feature value evaluator. The MAC in communication with the external network receives a data packet from the external network, and stores the data packet in the buffer in communication therewith. The feature value evaluator in communication with the buffer determines whether the data packet complies with a transfer condition according to a feature value included in the data packet, and actuates the MAC to assert an interrupt signal to the computer host when the feature value indicates the data packet complies with the transfer condition. A method for transferring a data packet between a computer host and an external network is also disclosed.
Abstract: Gentisic acid and its derivatives substantially inhibit peptide autoradiolysis. Gentisic acid or its derivatives may also be used in combination with other stabilizers such as inositol and ascorbic acid to inhibit autoradiolysis of radiolabeled peptides.
Type:
Grant
Filed:
October 13, 1993
Date of Patent:
January 24, 1995
Assignee:
Mallinckrodt Medical, Inc.
Inventors:
Edward A. Deutsch, Wilhelmus T. Goedemans, Martinus T. Maria de Jong, Kathleen M. Miller, James W. Brodack
Abstract: Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions.A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.
Type:
Grant
Filed:
June 3, 1992
Date of Patent:
June 8, 1993
Assignee:
Mallinckrodt Medical, Inc.
Inventors:
Raghavan Rajagopalan, Rebecca A. Wallace, Muthunadar P. Periasamy
Abstract: The invention relates to a diagnostic or radiotherapeutic composition, comprising a hydrogen containing compound in addition to a pharmaceutically acceptable formulation means and optionally an inactive carrier and/or one or more auxiliary substances, wherein the hydrogen containing compound comprises at least one deuterium atom. The invention further relates to a compound to be used for said composition and to a kit for preparing a radio-diagnostic composition.
Abstract: A diagnostic composition suitable for administration to a warm-blooded animal, which comprises a MRI-effective amount of a zwitterionic complex of a paramagnetic ion having a cyclic or open chain structure and a pharmaceutically acceptable carrier and a method for performing a MRI diagnostic procedure using the same.
Type:
Grant
Filed:
September 13, 1990
Date of Patent:
November 10, 1992
Assignee:
Mallinckrodt Medical, Inc.
Inventors:
Raghavan Rajagopalan, Donald R. VanDeripe
Abstract: Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.
Type:
Grant
Filed:
November 21, 1990
Date of Patent:
August 25, 1992
Assignee:
Mallinckrodt Medical, Inc.
Inventors:
Raghavan Rajagopalan, Rebecca A. Wallace, Muthunadar P. Periasamy
Abstract: The invention relates to a method of localizing and quantifying regional energy metabolism, in particular regional ischemia, in a warm-blooded living being, comprising administering to said being a diagonstically effective quantity of a radiolabelled L-homocysteine or a radiolabelled functional derivative thereof. The invention further relates to a pharmaceutical composition to be used for performing the above method.