Abstract: A polymorphic threat manager monitors an incoming email stream, and identifies incoming email messages to which executable files are attached. The polymorphic threat manager characterizes incoming executable files according to at least one metric. For example, the polymorphic threat manager can decompose an executable file into fragments, hash some or all of these, and use the hashes as characterization metrics. The polymorphic threat manager subsequently de-obfuscates executable files, and creates corresponding characterization metrics for the de-obfuscated images. The characterizations of executable files before and after de-obfuscation are compared, and if they differ sufficiently, the polymorphic threat manager determines that the file in question is polymorphic. The characterization metrics of such an executable file after de-obfuscation can be used as a signature for that file.