Abstract: The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent.
Type:
Grant
Filed:
March 6, 2012
Date of Patent:
January 1, 2013
Assignee:
University of Pittsburgh—of the Commonwealth System of Higher Education
Inventors:
William E. Klunk, Chester A. Mathis, Jr.
Abstract: A liquid applicator contains a hollow body portion incorporating a reservoir portion for containing a liquid to be applied by the applicator; an outlet portion having first and second ends, the first end being connected to an outlet mouth of the reservoir; an applicator tip assembly provided on the second end of the outlet portion for discharge of liquid from the reservoir portion via said outlet portion; a plug located in the mouth of the reservoir portion; and actuator for applying an actuating force to the mouth wall to effect movement of the plug towards the outlet portion and for squeezing the walls of the reservoir portion to effect discharge of liquid from the reservoir portion via the outlet portion and the applicator device. The liquid to be dispensed is retained in a reservoir that is sealed by a plug until usage.
Type:
Grant
Filed:
June 11, 2009
Date of Patent:
January 1, 2013
Assignee:
Advanced Medical Solutions (Plymouth) Limited
Abstract: A pressure detection apparatus (30) detects, among a plurality of superconductor thin films (11 to 14) having different critical pressures at which a transition from a superconductor to an insulator occurs, the superconductor thin films (12 to 14) that have undergone the transition to the insulator with ammeters (242, 252, 262); and to detect, as an internal pressure of a housing (10), the maximum critical pressure among the critical pressures of the detected superconductor thin films (12 to 14).
Abstract: The invention relates to a blower wheel, especially a plastic blower wheel for a cylindrical rotor radial fan for the heating and air-conditioning systems of a motor vehicle. Said blower wheel comprises a plurality of blades (2), and the flow channel (3) between two blades (2) is embodied in such a way that it is convergent on the inflow side, divergent on the outflow side, and distinctively shaped.
Type:
Grant
Filed:
July 4, 2006
Date of Patent:
December 25, 2012
Assignee:
Behr GmbH & Co. KG
Inventors:
Jörg Kilian, Peter Lucyga, Nikolaus Zipf
Abstract: A type of input stored by a packet in a recorded session is identified, this recorded session comprises a plurality of packets that represent display data that is generated by an application program. At least one of the packets can be marked responsive to determining the type of input stored in that packet. A destination for rendering the contents of the packet can also be stored in a playback data structure in response to marking at least one of the packets.
Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2 -isopropylpyrazolo[1,5-a]pyridine).
Type:
Grant
Filed:
February 22, 2012
Date of Patent:
December 25, 2012
Assignee:
Medicinova, Inc.
Inventors:
Michael E. Kalafer, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
Abstract: A disc prosthesis is provided. The disc prosthesis includes a concave surface attached to a first base and a convex surface attached to a second base. The concave surface and the convex surface together form a rotating joint, and at least one of the concave and convex surfaces is attached to its base through at least one flexible support capable of flexing to provide shock absorption when the artificial disc prosthesis is disposed between two vertebra.
Abstract: Plasma treatment apparatus and method for treatment of a surface of a substrate. A dielectric barrier discharge electrode structure is provided having a treatment space (5) and comprising a first electrode (2) and a second electrode (3), and a power supply (11) connected to the first electrode (2) and the second electrode (3) for generating an atmospheric pressure plasma in the treatment space (5). The plasma treatment apparatus further comprises a magnetic layer (6) provided on a surface of at least the first electrode (2). The first electrode (2) is arranged to receive, in operation, the substrate (1) to be treated and a mask device (7) in contact with the substrate (1), the mask device (7) interacting with the magnetic layer (6).
Type:
Grant
Filed:
February 1, 2008
Date of Patent:
December 25, 2012
Assignee:
Fujifilm Manufacturing Europe B.V.
Inventors:
Hindrik Willem De Vries, Bruno Alexander Korngold
Abstract: The present invention relates to nanoparticles containing pioglitazone or a salt thereof and a biocompatible polymer, a pharmaceutical preparation containing the nanoparticles for the prophylaxis or treatment of arteriosclerotic diseases, and a stent carrying the nanoparticles. Using the nanoparticles of the present invention, rupture of arteriosclerotic plaque can be suppressed, and they are useful for the prophylaxis or treatment of arteriosclerotic diseases.
Type:
Grant
Filed:
December 12, 2008
Date of Patent:
December 25, 2012
Assignees:
Kyushu University, National University Corporation, Takeda Pharmaceutical Company Limited
Abstract: The present invention provides a resin composition containing a liquid crystalline polyester and a high dielectric material filler. The present invention also provides a molded article of the liquid crystalline polyester resin composition. The liquid crystalline polyester resin composition of the present invention comprises 50 to 80% by volume of a liquid crystalline polyester which has 40% by mol or more of a 2,6-naphthalenediyl group as an aromatic group, also has a flow initiation temperature of 280° C. or higher, and shows a melt tension of 1 g or more measured at a temperature higher than flow initiation temperature; and 20 to 50% by volume of a high dielectric material filler. The liquid crystalline polyester resin composition can be formed into composition pellets easily and stably by a strand method, and a molded article obtained from the liquid crystalline polyester resin composition is excellent in flexural strength and dielectric characteristics.
Abstract: A method for providing, by a remote machine, access to functionality associated with a resource executing on a local machine includes receiving, by a remote agent executing on a remote machine, an identification of a shell extension associated with a resource provided by a local machine. The remote agent installs a proxy handler associated with the identified shell extension. The proxy handler receives a request for access to the shell extension and redirects the request to a shell extension invoker executing on the local machine.
Abstract: A susceptor includes a flexible substrate and a metallic material provided on at least one surface of the substrate. A first plurality of ventilation apertures are formed in the substrate and the metallic material, and the first plurality of ventilation apertures are configured to permit a fluid to pass through the substrate and the metallic material.
Type:
Grant
Filed:
August 25, 2008
Date of Patent:
December 25, 2012
Assignee:
The Hillshire Brands Company
Inventors:
Ian Michael Daines Gaylor, Charles Daniel Bonner, Annie Louise Charlotte Broadhurst
Abstract: Provided is a serial control device that makes the length of data transferred as one frame variable. The serial control device transfers serial data having an arbitrary length, and uses end information indicating inclusion or non-inclusion of end data of the serial data. The serial control device transfers data having a transfer unit length in the serial data when the end information indicates non-inclusion of the end data, and transfers an untransferred part of the serial data when the end information indicates inclusion of the end data.
Abstract: The thermoplastic resin composition (X1) of the present invention comprises (A1), (B1), (C1), and optionally (D1) below: 1 to 90 wt % of an isotactic polypropylene (A1); 9 to 98 wt % of a propylene/ethylene/?-olefin copolymer (B1) containing 45 to 89 mol % of propylene-derived structural units, 10 to 25 mol % of ethylene-derived structural units, and optionally, 0 to 30 mol % of C4-C20 ?-olefin-derived structural units (a1); 1 to 80 wt % of a styrene-based elastomer (C1); and 0 to 70 wt % of an ethylene/?-olefin copolymer (D1) whose density is in the range of 0.850 to 0.910 g/cm3, wherein (A1)+(B1)+(C1)+(D1)=100 wt %.
Abstract: A light fixture includes a first raceway disposed at a first end of the light fixture, a second raceway disposed at a second end of the light fixture, and a detachable cover that is removably coupled to the first raceway and to the second raceway. A ballast and power input wiring is coupled to the detachable cover, and an elongated lamp electrically coupled to the ballast. The light fixture also includes a power input connector having a socket portion and a plug portion, one of the socket portion and the plug portion coupled to the detachable cover and electrically connected to the power input wiring, and the other of the socket portion and the plug portion connectable to a power supply line to provide electrical power to the light fixture from a power source.
Type:
Grant
Filed:
March 19, 2012
Date of Patent:
December 25, 2012
Assignee:
Orion Energy Systems, Inc.
Inventors:
Neal R. Verfuerth, Ronald E. Ernst, Kenneth J. Wetenkamp
Abstract: When an upshift is performed while a traveling condition of a vehicle corresponds to a driving condition or a downshift is performed while the traveling condition of the vehicle corresponds to a coasting condition, a second target slip amount is set as a target slip amount for a period extending from the start of gear ratio variation following issuance of a gear position change start command to completion of the gear ratio change, and when a downshift is performed in the driving condition or an upshift is performed in the coasting condition, a first target slip amount is set as the target slip amount for a period extending from issuance of the shift command to completion of the shift.
Abstract: A method for reporting one or more results that occur based on a price change includes receiving price planning input including at least one price change from at least one of an automated pricing engine and a manual pricing engine. The method further includes generating at least one result that will occur based on the price planning input and reporting the at least one result along with the at least one price change.
Abstract: Systems and methods for configuring and evaluating policies that direct processing of one or more data streams are described. A configuration interface is described for allowing users to specify object oriented policies. These object oriented policies may allow any data structures to be applied with respect to a payload of a received packet stream, including any portions of HTTP traffic. A configuration interface may also allow the user to control the order in which policies and policy groups are executed, in addition to specifying actions to be taken if one or more policies are undefined. Systems and methods for processing the policies may allow efficient processing of object-oriented policies by applying potentially complex data structures to unstructured data streams. A device may also interpret and process a number of flow control commands and policy group invocation statements to determine an order of execution among a number of policies and policy groups.
Abstract: A method for folding an airbag for an airbag module in which the airbag is disposed on a support is provided. At least one piling element for folding the airbag is provided next to the exterior edge of the airbag disposed on the support. The airbag is folded together using the at least one piling element in that the piling element is moved along the support in the direction toward the interior of the airbag disposed on the support. A retainer protrudes from the at least one piling element and moving together with the piling element during the movement thereof and reaching over or under an edge area of the airbag. The at least one retainer acts on an edge area of the airbag in such a way that an undercut is formed in the airbag through the effect of the retainer.