Abstract: Novel spiro-oxazolidindiones useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. Pharmaceutical compositions containing the novel compounds and a method of treating chronic diabetic complications are also disclosed.

Abstract: An aqueous manganese micronutrient solution comprising between 0.1 and 2.0 wt. % of ferrous ion, about 5 wt. % manganous ion, between 1 and 1.5 moles of citric acid anion per mole of manganous ion and ammonia in an amount to maintain the pH of the solution between 7.5 and 12.

Abstract: Azacycloalkanes, and derivatives thereof, including unsaturated analogs, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.

Abstract: A process for producing 2,5-diketogluconic acid which comprises aerobically propagating Acetobacter cerinus in a D-glucose-containing fermentation medium.

Abstract: Pharmaceutical compositions containing magnesium-calcium-oxytetracycline mixed chelates in aqueous 2-pyrrolidone solution are disclosed.

Abstract: Novel 2-(Imidazol-1-ylmethyl)pyrroles and pharmaceutically acceptable acid addition salts thereof are disclosed. The novel compounds are useful in selectively inhibiting the action of the thromboxane synthetase enzyme.

Abstract: 2.beta.-Acetoxymethyl-2.alpha.-methyl-(5R)penam-3.alpha.-carboxylic acid 1,1-dioxide, pharmaceutically-acceptable salts thereof and esters thereof readily hydrolyzable in vivo; pharmaceutical compositions containing 2.beta.-acetoxymethyl-2.alpha.-methyl-(5R)penam-3.alpha.-carboxylic acid 1,1-dioxide or salt or ester thereof; and method of enhancing the effectiveness of a .beta.-lactam antibiotic using 2.beta.-acetoxymethyl-2.alpha.-methyl-(5R)penam-3.alpha.-carboxylic acid 1,1-dioxide or salt or ester thereof.

Abstract: An improved process for the preparation of L-aspartic acid N-thiocarboxyanhydride by the reaction of a 0.75 to 1.25 molar solution of an N-alkoxy-thiocarbonyl L-aspartic acid in a lower alkyl acetate solvent with a phosphorous trihalide. The desired product is substantially insoluble in the lower alkyl acetate solvent and is recovered in pure form without further purification or separation steps.

Abstract: 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines and derivatives thereof useful as immune regulants are disclosed. Also disclosed are pharmaceutical compositions containing the novel compounds and a method of regulating the immune response of a subject by administration of the novel compounds.

Abstract: Amine polymers are used to dewater suspensions of particulate matter in water. The polymers are synthesized by the reaction of a nitrile polymer such as polyacrylonitrile, an aminating agent, and a sulfur activator. The dewatering properties of these amine polymers can be beneficially employed to treat sewage sludge, silt laden water, industrial waste and the like.

Abstract: Medicinal agents classed as 2-(aminoalkyl or amidoalkyl)-5-aryl-hexahydro-trans-4a,9b-1(H)-pyrido[4,3-b]indole derivatives have been synthesized and found to have neuroleptic activity.

Abstract: Compositions of nitrite preserved food, emulsified preparations, breakfast cereal or food premixes and erythorbyl or ascorbyl laurate or erythorbyl caprate show substantial inhibition of potentially harmful or objectionable degradation arising from N-nitrosamine formation or oxidation.

Abstract: A series of amino-and alkylamino-substituted spirohydantoins and pharmaceutically acceptable salts thereof useful as inhibitors of the enzyme aldose reductase and as therapeutic agents for the treatment of chronic complications associated with diabetes are disclosed. Preferred compounds include 6-chloro-8-amino-spiro[4H-2,3-dihydro-1-benzopyran-4,4'-imidazolidine]-2', 5'-dione, the 6-fluoro and 8-methylamino- analogs thereof and the corresponding dihydrobenzothiopyran analogs of these compounds. The optical isomers of these compounds having the 4S-configuration are especially preferred.

Abstract: The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxy-quinolines and 2-amino-.alpha.,.alpha.-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxy-quinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxy-pyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.

Abstract: 2-Keto-L-gulonic acid, an ascorbic acid intermediate, is prepared by cultivating a microorganism of the genus Citrobacter in an aqueous nutrient medium in the presence of 2,5-diketo-D-gluconic acid.

Abstract: A novel porous, weakly acidic, itaconic acid ion exchange resin and a process for its preparation are disclosed. The process comprises the copolymerization of the beta-monoalkyl ester of itaconic acid and a cross-linking agent such as divinyl benzene in the presence of a pore forming agent selected from the group consisting of aliphatic hydrocarbons of from 5 to 8 carbon atoms, alicyclic hydrocarbons of from 5 to 8 carbon atoms and halogenated hydrocarbons of from 1 to 3 carbon atoms, followed by hydrolysis of the resulting copolymer. The macroreticular itaconic acid ion exchange resin of this invention is characterized by an excellent combination of exchange capacity, heavy metals capturing capacity, ion exchange rate and gas adsorptive capacity.

Abstract: 6'-Acylaminopenicillanoyloxymethyl esters of penicillanic acid 1,1-dioxide are useful as antibacterial agents. The 6'-aminopenicillanoyloxymethyl ester, halomethyl esters, alkylsulfonyloxymethyl esters and arylsulfonyloxymethyl esters of penicillanic acid 1,1-dioxide are all useful intermediates for the aforesaid antibacterial agents.

Abstract: L-Aspartyl-L-phenylalanine alkyl esters prepared by the reaction of L-aspartic acid N-thiocarboxyanhydride and an appropriate L-phenylalanyl alkyl ester are deodorized by contacting the L-aspartyl-L-phenylalanine alkyl ester in aqueous solution with an effective amount of an alkali metal periodate.

Abstract: A novel closure means for an opening of a body eliminations or secretions collection appliance is disclosed. Said closure means comprises a semi-rigid strip securely affixed adjacent to one of the walls of the collection appliance. The opening is closed by lap folding the extremity of the collection appliance upon itself and then tucking the folded extremity into a gap between said strip and said wall. The novel closure means is particularly well suited for releasable closure of the drainage opening of an ostomy collection appliance.

Abstract: Synthetic prostaglandin E compounds having carboxylic acid, ester, tetrazol, sulfonamide or imide substitutions at C-1, a methanesulfonamido group replacing the C-15 hydroxy and an aryloxy group at C-16 are disclosed. They exhibit antisecretory biological activity.