Abstract: Mercaptoalkylpyridines and various derivatives thereof have utility in the treatment of rheumatoid arthritis. The compounds useful in the method of treatment are generally prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.
Type:
Grant
Filed:
May 11, 1976
Date of Patent:
November 8, 1977
Assignee:
Merck & Co., Inc.
Inventors:
Tsung-Ying Shen, Howard Jones, Dennis M. Mulvey, Conrad P. Dorn
Abstract: Paper products exhibiting markedly improved dry strength properties are produced by adding to the cellulose paper dispersion a chitin-based compound comprising chitosan alone or a graft copolymer of certain acrylic and/or diallylic monomers grafted onto the chitosan as a substrate.
Type:
Grant
Filed:
July 6, 1971
Date of Patent:
November 1, 1977
Assignee:
Calgon Corporation
Inventors:
Robert Clayton Slagel, Gloria DiMarco Sinkovitz
Abstract: Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.
Type:
Grant
Filed:
July 16, 1976
Date of Patent:
October 11, 1977
Assignee:
Merck & Co., Inc.
Inventors:
Tsung-Ying Shen, Howard Jones, Conrad P. Dorn
Abstract: 5-Mercaptopyridoxine C.sub.1-4 alkane sulfonates, particularly the ethane-1,2-disulfonate, is a superior pharmaceutically acceptable form of the previously preferred 5-mercaptopyridoxine hydrochloride and hydrobromide.
Type:
Grant
Filed:
March 15, 1976
Date of Patent:
September 6, 1977
Assignee:
Merck & Co., Inc.
Inventors:
Conrad P. Dorn, Howard Jones, David P. Jacobus
Abstract: The invention relates to a novel class of 4-(benzoxazol-2-yl)phenylacetic acids, alcohols, esters, amides and the non-toxic pharmaceutically acceptable salts thereof and processes for their preparation. The invention further pertains to a class of (benzoxazol-2-yl)phenylacetic acids useful as antiinflammatory agents.
Type:
Grant
Filed:
August 14, 1975
Date of Patent:
September 6, 1977
Assignee:
Merck & Co., Inc.
Inventors:
Tsung-Ying Shen, Jorge P. Li, Conrad P. Dorn, Jr.
Abstract: The invention relates to substituted 5-(phenyl)benzoic acid esters and non-toxic pharmaceutically accepted salts thereof and processes for their preparation. The substituted 5-(phenyl)benozic acids are useful as anti-inflammatory compounds. Also included are method of treating inflammation claims by administering these particular compounds to patients.
Type:
Grant
Filed:
October 8, 1971
Date of Patent:
August 23, 1977
Assignee:
Merck & Co., Inc.
Inventors:
William V. Ruyle, Lewis H. Sarett, Alexander R. Matzuk
Abstract: The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.
Type:
Grant
Filed:
May 2, 1975
Date of Patent:
July 26, 1977
Assignee:
Merck & Co., Inc.
Inventors:
Tsung-Ying Shen, Robert L. Clark, Arsenio A. Pessolano, Bruce E. Witzel, Thomas J. Lanza
Abstract: Multitoned compressed tablet forms of pleasing and distinctive appearance are obtained in a single granulation and coloring step by treating an excipient mixture of microcrystalline cellulose and modified corn starch containing a therapeutically effective quantity of an active drug or drugs with a granulating solution containing a water soluble dye suitable for pharmaceutical application. Work-up of the wetted granulation by usual wet granulation techniques followed by compression of the finished granules results in a distinctive multitoned tablet form.
Type:
Grant
Filed:
July 14, 1975
Date of Patent:
July 5, 1977
Assignee:
Merck & Co., Inc.
Inventors:
Joseph B. Schwartz, Frederick A. Restaino
Abstract: Oxazolo[4,5-b]pyridine substituted in the 2-position with a polyhydrobicycloaryl group are topical anti-inflammatory agents. They are prepared by condensing a 2-amino-3-hydroxypyridine with the appropriate carboxylic compound.
Abstract: 3H-1,2,3-Triazolo[4,5-b]pyridines substituted in the 3-position have utility as analgesic, anti-inflammatory and anti-pyretic agents. They are prepared by diazotization of a 3-amino-2-(substitute) aminopyridine.
Type:
Grant
Filed:
October 3, 1975
Date of Patent:
December 28, 1976
Assignee:
Merck & Co., Inc.
Inventors:
Robert L. Clark, Arsenio A. Pessolano, Tsung-Ying Shen
Abstract: A vaccine for immunological control of fertility is disclosed comprising solubilized mammalian zona pellucida; also disclosed are antisera specific against the antigenic mammalian zona pellucida; processes for the preparation of such vaccine and antisera; and methods of treatment comprising administering such vaccine and antisera for the immunological control of fertility.
Abstract: Biaryl coupling, particularly to form 2,4-difluorobiphenyl, is accomplished by diazotizing an aniline and coupling the benzenediazonium salt with a second aromatic component in the presence of a strong acid, an inert finely divided solid and copper powder or a copper salt.
Type:
Grant
Filed:
May 1, 1975
Date of Patent:
November 16, 1976
Assignee:
Merck & Co., Inc.
Inventors:
Torleif Utne, Ronald B. Jobson, Alfred V. Lovell
Abstract: Palatable oral coacervate compositions containing Cholestyramine and a Modified Gum selected from the group consisting of hydrophilic colloid of cellulosive material and charged anionic gum in an aqueous medium.
Abstract: S,S'-bis(pyridylmethyl)-carbonodithioates and derivatives thereof have utility in the treatment of rheumatoid arthritis. The compound useful in the method of treatment is prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.
Type:
Grant
Filed:
May 16, 1974
Date of Patent:
July 27, 1976
Assignee:
Merck & Co., Inc.
Inventors:
Tsung-Ying Shen, Howard Jones, Dennis M. Mulvey, Conrad P. Dorn
Abstract: Vitamin C in beverages such as natural and manufactured fruit and vegetable flavored drinks is stabilized by addition of controlled quantities of cysteine without adverse effects on taste. More especially, beverages containing both Vitamin C and metabolically available iron are stabilized by addition of cysteine, all in specific ratios.
Abstract: One-pass electroconductive coating color formulations are achieved by incorporating into electroconductive coating color formulations an effective quantity of a perfluoroalkyl phosphate salt.
Abstract: The invention disclosed herein relates to processes and intermediates useful in the preparation of certain 16-lower alkyl-1,4-pregnadiene compounds. It is particularly concerned with novel methods of preparing 16-lower alkyl-9.alpha.-fluoro-11.beta.,17.alpha.,21-trihydroxy-1,4-pregndiene-3,20 -dione and esters thereof, and with novel intermediates useful in these novel methods. It is further concerned with 16-lower alkyl-1,4,9(11)-pregnatriene-17.alpha.,21-diol-3,20-diones and their 21-lower alkanoates which, in addition to being valuable as intermediates, are valuable diuretic agents useful in the treatment of edema.