Patents Represented by Attorney Frank M. Mahon
  • Patent number: 4057637
    Abstract: Mercaptoalkylpyridines and various derivatives thereof have utility in the treatment of rheumatoid arthritis. The compounds useful in the method of treatment are generally prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.
    Type: Grant
    Filed: May 11, 1976
    Date of Patent: November 8, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Dennis M. Mulvey, Conrad P. Dorn
  • Patent number: 4056432
    Abstract: Paper products exhibiting markedly improved dry strength properties are produced by adding to the cellulose paper dispersion a chitin-based compound comprising chitosan alone or a graft copolymer of certain acrylic and/or diallylic monomers grafted onto the chitosan as a substrate.
    Type: Grant
    Filed: July 6, 1971
    Date of Patent: November 1, 1977
    Assignee: Calgon Corporation
    Inventors: Robert Clayton Slagel, Gloria DiMarco Sinkovitz
  • Patent number: 4053606
    Abstract: Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.
    Type: Grant
    Filed: July 16, 1976
    Date of Patent: October 11, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Conrad P. Dorn
  • Patent number: 4046897
    Abstract: 5-Mercaptopyridoxine C.sub.1-4 alkane sulfonates, particularly the ethane-1,2-disulfonate, is a superior pharmaceutically acceptable form of the previously preferred 5-mercaptopyridoxine hydrochloride and hydrobromide.
    Type: Grant
    Filed: March 15, 1976
    Date of Patent: September 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Conrad P. Dorn, Howard Jones, David P. Jacobus
  • Patent number: 4046905
    Abstract: The invention relates to a novel class of 4-(benzoxazol-2-yl)phenylacetic acids, alcohols, esters, amides and the non-toxic pharmaceutically acceptable salts thereof and processes for their preparation. The invention further pertains to a class of (benzoxazol-2-yl)phenylacetic acids useful as antiinflammatory agents.
    Type: Grant
    Filed: August 14, 1975
    Date of Patent: September 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Jorge P. Li, Conrad P. Dorn, Jr.
  • Patent number: 4044049
    Abstract: The invention relates to substituted 5-(phenyl)benzoic acid esters and non-toxic pharmaceutically accepted salts thereof and processes for their preparation. The substituted 5-(phenyl)benozic acids are useful as anti-inflammatory compounds. Also included are method of treating inflammation claims by administering these particular compounds to patients.
    Type: Grant
    Filed: October 8, 1971
    Date of Patent: August 23, 1977
    Assignee: Merck & Co., Inc.
    Inventors: William V. Ruyle, Lewis H. Sarett, Alexander R. Matzuk
  • Patent number: 4038396
    Abstract: The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: July 26, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Robert L. Clark, Arsenio A. Pessolano, Bruce E. Witzel, Thomas J. Lanza
  • Patent number: 4034035
    Abstract: Multitoned compressed tablet forms of pleasing and distinctive appearance are obtained in a single granulation and coloring step by treating an excipient mixture of microcrystalline cellulose and modified corn starch containing a therapeutically effective quantity of an active drug or drugs with a granulating solution containing a water soluble dye suitable for pharmaceutical application. Work-up of the wetted granulation by usual wet granulation techniques followed by compression of the finished granules results in a distinctive multitoned tablet form.
    Type: Grant
    Filed: July 14, 1975
    Date of Patent: July 5, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Joseph B. Schwartz, Frederick A. Restaino
  • Patent number: 4011326
    Abstract: Oxazolo[4,5-b]pyridine substituted in the 2-position with a polyhydrobicycloaryl group are topical anti-inflammatory agents. They are prepared by condensing a 2-amino-3-hydroxypyridine with the appropriate carboxylic compound.
    Type: Grant
    Filed: July 29, 1975
    Date of Patent: March 8, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Norman P. Jensen
  • Patent number: 4000286
    Abstract: 3H-1,2,3-Triazolo[4,5-b]pyridines substituted in the 3-position have utility as analgesic, anti-inflammatory and anti-pyretic agents. They are prepared by diazotization of a 3-amino-2-(substitute) aminopyridine.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: December 28, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Clark, Arsenio A. Pessolano, Tsung-Ying Shen
  • Patent number: 3992520
    Abstract: A vaccine for immunological control of fertility is disclosed comprising solubilized mammalian zona pellucida; also disclosed are antisera specific against the antigenic mammalian zona pellucida; processes for the preparation of such vaccine and antisera; and methods of treatment comprising administering such vaccine and antisera for the immunological control of fertility.
    Type: Grant
    Filed: November 27, 1974
    Date of Patent: November 16, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Ralph B. L. Gwatkin
  • Patent number: 3992459
    Abstract: Biaryl coupling, particularly to form 2,4-difluorobiphenyl, is accomplished by diazotizing an aniline and coupling the benzenediazonium salt with a second aromatic component in the presence of a strong acid, an inert finely divided solid and copper powder or a copper salt.
    Type: Grant
    Filed: May 1, 1975
    Date of Patent: November 16, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Torleif Utne, Ronald B. Jobson, Alfred V. Lovell
  • Patent number: 3974272
    Abstract: Palatable oral coacervate compositions containing Cholestyramine and a Modified Gum selected from the group consisting of hydrophilic colloid of cellulosive material and charged anionic gum in an aqueous medium.
    Type: Grant
    Filed: January 25, 1974
    Date of Patent: August 10, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Gerald P. Polli, Clyde E. Shoop
  • Patent number: 3971797
    Abstract: S,S'-bis(pyridylmethyl)-carbonodithioates and derivatives thereof have utility in the treatment of rheumatoid arthritis. The compound useful in the method of treatment is prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.
    Type: Grant
    Filed: May 16, 1974
    Date of Patent: July 27, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Dennis M. Mulvey, Conrad P. Dorn
  • Patent number: 3962430
    Abstract: Sterilization of solid non-electrolyte medicinal agents by heating in an aqueous suspension which contains excess sodium chloride.
    Type: Grant
    Filed: July 14, 1975
    Date of Patent: June 8, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Joseph L. O'Neill
  • Patent number: 3958017
    Abstract: Vitamin C in beverages such as natural and manufactured fruit and vegetable flavored drinks is stabilized by addition of controlled quantities of cysteine without adverse effects on taste. More especially, beverages containing both Vitamin C and metabolically available iron are stabilized by addition of cysteine, all in specific ratios.
    Type: Grant
    Filed: November 15, 1974
    Date of Patent: May 18, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Lewis D. Morse, Paul A. Hammes
  • Patent number: 3953374
    Abstract: One-pass electroconductive coating color formulations are achieved by incorporating into electroconductive coating color formulations an effective quantity of a perfluoroalkyl phosphate salt.
    Type: Grant
    Filed: February 19, 1974
    Date of Patent: April 27, 1976
    Assignee: Calgon Corporation
    Inventor: Robert H. Windhager
  • Patent number: 3947409
    Abstract: The invention disclosed herein relates to processes and intermediates useful in the preparation of certain 16-lower alkyl-1,4-pregnadiene compounds. It is particularly concerned with novel methods of preparing 16-lower alkyl-9.alpha.-fluoro-11.beta.,17.alpha.,21-trihydroxy-1,4-pregndiene-3,20 -dione and esters thereof, and with novel intermediates useful in these novel methods. It is further concerned with 16-lower alkyl-1,4,9(11)-pregnatriene-17.alpha.,21-diol-3,20-diones and their 21-lower alkanoates which, in addition to being valuable as intermediates, are valuable diuretic agents useful in the treatment of edema.
    Type: Grant
    Filed: October 11, 1974
    Date of Patent: March 30, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Ralph F. Hirschmann