Patents Represented by Attorney, Agent or Law Firm Gary T. Hampson
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Patent number: 6388750Abstract: A device and method for performing a preliminary test on a neat serum sample contained in a primary collection tube is provided herein. The method includes the steps of positioning of an optical probe near the primary collection tube and monitoring the neat serum sample in the primary collection tube to determine whether an interferant, such as hemolysis, icteris and lipemia are present in the serum sample. From this test, a hemolytic index, an icteric index and a lipemic index can also be established for the neat serum sample. Based upon these serum indices, the neat serum sample can be transferred to a clinical analyzer for additional testing or to waste receptacle because the sample is compromised. Additionally, a volume test can be performed on the serum sample in the primary collection tube so that the serum sample can be properly allocated during subsequent testing.Type: GrantFiled: December 17, 1998Date of Patent: May 14, 2002Assignee: Beckman Coulter, Inc.Inventors: Yangang Liu, Tung Rung Wang, Ian Nguyen, Shirley Pfeifer, Jack McNeal
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Patent number: 6284873Abstract: The present invention provides a novel complex of hK2 and PI-6 and methods of using the novel complex. The novel complexes of hK2 and PI-6 of the present invention exist at an elevated level in prostate cancer tissues. Therefore, the hK2-PI6 complexes of the present invention may be used as a serum marker for detecting prostate cancer. They may also be used as an immunohistological marker to detect prostate cancer tissues. In accordance with the present invention, the hK2-PI6 complexes of the present invention may be detected in patient tissue samples by immunohistochemical and/or in patient fluid samples by in vitro immunoassay procedures. Diagnostic kits and diagnostic methods for detecting the existence of prostate cancer are also provided.Type: GrantFiled: March 12, 1999Date of Patent: September 4, 2001Assignee: Hybritech IncorporatedInventors: Stephen D. Mikolajczyk, Mohammad S. Saedi
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Patent number: 5858644Abstract: A method for detecting an analyte in a sample uses both the specificity of an enzymatic reaction and the separation power of capillary electrophoresis.Type: GrantFiled: May 30, 1995Date of Patent: January 12, 1999Assignee: Beckman Instruments, Inc.Inventor: Fu-Tai Albert Chen
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Patent number: 5747352Abstract: Bidentate reagents for rapidly and quantitatively assaying the concentration of pharmacological agents in biological samples are described. The reagents are used in an immunoassay format for determining the concentration of desired, preselected pharmacological agents, such as benzoylecgonine, cocaine, an opiate, PCP, digoxigenin, acetaminophen, carbamazepine, phenytoin, primidone, theophylline, an aminoglycoside antibiotic, vancomycin, quinidine or a cannabinoid.Type: GrantFiled: May 23, 1994Date of Patent: May 5, 1998Assignee: Beckman Instruments, Inc.Inventors: Cheng F. Yan, Chan S. Oh, Anthony K. Cheng
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Patent number: 5679309Abstract: An improved automated diagnostic analyzer and method of the type which includes a reaction carousel having cuvettes to receive sample and reactant for photometric analysis and to index and park for addition of sample, reactant and washing of cuvettes. Alternative reactant and/or sample addition points are provided so the analyzer controller may index cuvettes to provide greater frequency at which washing of cuvettes may take place simultaneously with addition of sample or reactant.Type: GrantFiled: December 14, 1995Date of Patent: October 21, 1997Assignee: Beckman Instruments, Inc.Inventor: Michael Bell
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Patent number: 5627080Abstract: Methods for modulating the rates and dose responses of immunoassays through the incorporation of one or more detergents into the immunoassay reaction are disclosed. The methods are particularly suitable for automated immunoassay formats, especially with formats that use analyte-biotin bidentate reagents. The methods may be used to facilitate the detection of any desired, preselected pharmacological agent.Type: GrantFiled: July 29, 1994Date of Patent: May 6, 1997Assignee: Beckman Instruments, Inc.Inventors: Anthony K. Cheng, Julie S. Kim, Chan S. Oh
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Patent number: 5622675Abstract: A sample segment including a body and wells formed therein, selected wells including a flat exterior surface surrounding a tapered end. The sample segment may retain selected reagents, and a sealing cover is held by ribs, stretched and pressed against raised bosses formed around the well openings to provide a sure seal. The bosses are discontinuous between adjacent wells. Selected wells may contain a free mixing element for enhanced mixing. The segment is uniquely adapted for automated handling and processing.Type: GrantFiled: June 13, 1995Date of Patent: April 22, 1997Assignee: Beckman Instruments, Inc.Inventors: Ronald C. Glenday, David L. Goodale, Steven D. Mack
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Patent number: 5607863Abstract: An assay device for detection and/or determination of an analyte in a test sample uses a barrier containing an aperture to control the application of reagents to the device for greater reproducibility of results. In its simplest form, the device comprises: (1) a chromatographic medium having a first end, a second end, and first and second surfaces, and having a specific binding partner for the analyte immobilized thereto in a detection zone; (2) at least one absorber in operable contact with at least one of the first and second ends; and (3) a substantially fluid-impermeable barrier adjacent to the first surface of the chromatographic medium, the barrier having at least one aperture therethrough for application of liquid to the chromatographic medium, the barrier at least partially blocking application of liquid to the chromatographic medium.Type: GrantFiled: December 7, 1993Date of Patent: March 4, 1997Assignee: SmithKline Diagnostics, Inc.Inventor: Howard M. Chandler
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Patent number: 5589574Abstract: Monoclonal antibodies highly specific for human bone alkaline phosphatase, especially in the presence of human liver alkaline phosphatase, and their use in assays for human bone alkaline phosphatase are disclosed. A kit using the antibodies in an assay for human bone alkaline phosphatase is also disclosed.Type: GrantFiled: June 2, 1995Date of Patent: December 31, 1996Assignee: Hybritech, IncorporatedInventors: Robert L. Wolfert, Craig S. Hill
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Patent number: 5552032Abstract: A solid state ion-selective electrode device to detect a selected ion species in solution an electrode consisting of a homogeneous solid mixture. The mixture is a solid electrolyte composition possessing ionic conductivity and polyvinyl chloride, and optionally graphite. The electrode is substantially free of metallic silver. An electrical connection operates as a contact between the electrode device and a reference source. Methods for detecting the selected ion species in solutions, such as biological samples utilizing the above described electrodes, are also disclosed.Type: GrantFiled: April 24, 1995Date of Patent: September 3, 1996Assignee: Beckman Instruments, Inc.Inventors: Youqin Xie, John N. Harman, III
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Patent number: 5534620Abstract: A novel heterogenous purification method is disclosed. The method removes a macromolecule from a liquid by allowing the macromolecule to undergo a specific binding affinity reaction with a bidentate conjugate. The method is carried out by immobilizing the bidentate conjugate on a solid phase, contacting the bidentate conjugate with the liquid comprising the macromolecule, and separating the immobilized bidentate conjugate from contact with the liquid, thereby removing the macromolecule from the liquid to obtain either purified macromolecule or a purified liquid.Type: GrantFiled: May 25, 1995Date of Patent: July 9, 1996Assignee: Beckman Instruments, Inc.Inventors: Chan S. Oh, Elizabeth K. Kearns
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Patent number: 5492834Abstract: Processes are provided for pretreating body fluid compositions and subsequently analyzing the pretreated body fluid compositions for analytes of interest. Processes for pretreating the compositions include providing size exclusion gel having a molecular weight fractionation range or a molecular weight exclusion such that the size exclusion gel is capable of excluding or fractionating the analytes of interest, and then causing the composition to contact the size exclusion gel in order to separate the analytes from low molecular weight composition components which interfere with the separation and analysis of the analytes of interest. Processes for analyzing pretreated compositions include electrophoretic methods such as capillary zone electrophoresis which involve the separation and detection of analytes of interest.Type: GrantFiled: July 9, 1993Date of Patent: February 20, 1996Assignee: Beckman Instruments, Inc.Inventors: Cheng-Ming Liu, Hann-Ping Wang
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Patent number: 5456653Abstract: A centrifuge includes a drive shaft-to-hub coupling assembly for providing vibration damping that is selective to torsional damping over lateral damping. An impeller is fixed to a drive shaft and a receiver is fixed to a rotor-bearing hub. Relative rotation between the impeller and the receiver is restricted to compression and decompression of elastomers trapped between teeth extending from the impeller and from the receiver. The elastomers function to damp torsional vibrations and torsionally induced lateral vibrations. The receiver is prevented from becoming axially misaligned with the impeller by including one or more rigid annular bushings that maintain the distance between the hub and the drive shaft, thereby preventing the elastomers from being deformed in a manner which would damp lateral vibrations. The annular bushing is mounted to allow relative rotation between the impeller and the receiver.Type: GrantFiled: July 7, 1994Date of Patent: October 10, 1995Assignee: Beckman Instruments, Inc.Inventor: Herschel E. Wright
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Patent number: 5443438Abstract: An assembly for transferring rotation from a centrifuge drive system to a centrifuge rotor includes a hub that is connected to the drive system for rotation about an axis. A sleeve member is attached to the hub in a position to support the centrifuge rotor. The sleeve member is formed of a material having a low coefficient of friction and is positioned to reduce the likelihood of rotor-to-hub lock. The resistance of the sleeve member to wear and to the absorption of foreign matter are also important in the selection of a material for forming the sleeve member. An acetal-based compound is preferred. By connecting the sleeve member to the hub such that the exterior surface of the sleeve member is raised relative to the surface of the hub, rotor-to-hub contact is reduced, thereby further reducing the risk that the rotor and the hub will become locked to one another.Type: GrantFiled: July 29, 1994Date of Patent: August 22, 1995Assignee: Beckman Instruments, Inc.Inventors: Herschel E. Wright, Cory Y. Chern
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Patent number: 5412819Abstract: A specimen collection device including a sheet of flexible material and two generally parallel slits formed near opposite edges of the sheet. This sheet is preferably rectangular and is of sufficient dimensions such that the slits may receive a conventional toilet seat to suspend a central portion of the device under the seat within a toilet bowl. The central portion is adapted to receive a fecal specimen and the device and specimen may be easily disposed of.Type: GrantFiled: July 8, 1994Date of Patent: May 9, 1995Assignee: Beckman Instruments, Inc.Inventors: Richard S. Matusewicz, Josefina T. Baker
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Patent number: 5413686Abstract: An automated multi-channel capillary electrophoresis analyzer includes a plurality of capillaries having first and second ends. The first ends of the capillaries are adapted to be collectively transported to and from selected reagent reservoirs. The second ends of the capillaries are removably and sealable retained within a common manifold that is in turn in selectable fluid communication with selected reagents and a vacuum source.Type: GrantFiled: July 17, 1992Date of Patent: May 9, 1995Assignee: Beckman Instruments, Inc.Inventors: Gerald L. Klein, Gary A. Miller
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Patent number: 5411465Abstract: A centrifuge rotor which makes use of a composite ring to support a segmented core body. The core body is segmented into sectors. The core segments are slidably coupled to a hub in a manner such that they can move radially relative to the hub upon centrifugation with substantially no radial tensile stress build up in the coupling between the hub and the core segments and within the segment cores. In another aspect of the present invention, to augment the segmented core rotor, hybrid composite sample holders are utilized to further improve overall strength-to-weight of the rotor. The holders comprise a metal portion and a fiber composite portion integrally molded.Type: GrantFiled: October 21, 1993Date of Patent: May 2, 1995Assignee: Beckman Instruments, Inc.Inventors: Stefan J. Glen, Bradley D. Carstens
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Patent number: 5395001Abstract: The present invention is directed to a floating cap or spacer and centrifuge tube assembly which provide adequate resistance to the deforming forces exerted on it. The exterior wall of the tube stem is provided with an annular ridge and the support spacer is provided with an annular groove which mates with the ridge on the tube stem to form an interlocking coupling.Type: GrantFiled: April 2, 1993Date of Patent: March 7, 1995Assignee: Beckman Instruments, Inc.Inventor: Patrick O. Moore
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Patent number: 5391498Abstract: Improved fecal occult blood test having a matrix such as paper printed or impregnated with guaiac. The improvement comprises increasing the sensitivity while maintaining or improving the specificity of the test by employing an alcoholic-peroxide developing solution which contains an enhancing agent. The enhancers comprise phenolic type compounds such as esters of parahydroxybenzoic acids.Type: GrantFiled: December 13, 1991Date of Patent: February 21, 1995Assignee: Smithkline Diagnostics, Inc.Inventors: Josefina T. Baker, Peter U. Ly, Eli Z. Olivet
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Patent number: RE35071Abstract: A centrifuge rotor and method for gradient density separation which supports a generally cylindrical volume of sample solution with its axis inclined to the spin axis at an angle which is optimized for maximum separation efficiency while reducing contamination by undesirable centrifugates upon reorientation of the desirable centrifugates. .Iadd.The sample solution is contained in a centrifuge tube which is closed at its top end by a top portion which is supported by a support cap. The undesirable centrifugates are pelleted to the end corners of the inclined centrifuge tube. The rotor and method are particularly adapted, for example, for separation of nucleic acid into plasmid DNA and chromosomal DNA by density gradient centrifugation. .Iaddend.The optimum angle is determined based on the relationship .theta.=Tan.sup.-1 (D/15L).sup.0.5 where D and L are respectively the diameter and length of the cylindrical volume of the sample solution and .theta. is the angle of inclination.Type: GrantFiled: June 18, 1993Date of Patent: October 24, 1995Assignee: Beckman Instruments, Inc.Inventors: Mark L. Lewis, Thomas D. Sharples, Stephen E. Little