Patents Represented by Attorney Genencor International, Inc.

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  • Proteins producing an altered immunogenic response and methods of making and using the same
    Patent number: 6936249
    Abstract: The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions. Moreover, naturally occurring proteins are provided.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: August 30, 2005
    Assignee: Genencor International, Inc.
    Inventors: David A. Estell, Fiona A. Harding
  • Enzymes useful for changing the properties of polyester
    Patent number: 6933140
    Abstract: A polyesterase enzyme which produces a positive result in an UV and/or MB assay is used to treat polyester to modify polyester properties such as pilling, pilling prevention, weight, feel, appearance and luster.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: August 23, 2005
    Assignee: Genencor International, Inc.
    Inventors: Wade Dyson, James T. Kellis, Jr., Ayrookaran J. Poulose, Mee-Young Yoon
  • Proteins producing an altered immunogenic response and methods of making and using the same
    Patent number: 6929939
    Abstract: The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: August 16, 2005
    Assignees: Genencor International, Inc., The Procter & Gamble Company
    Inventors: David A. Estell, Grant C. Ganshaw, Fiona A. Harding, Edmund A. Larenas, Ayrookaran J. Poulose, Elizabeth E. Sikorski, Elliott P. Russell
  • Multiply-substituted protease variants
    Patent number: 6927055
    Abstract: Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 62, 212, 230, 232, 252 and 257 of Bacillus amyloliquefaciens subtilisin.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: August 9, 2005
    Assignee: Genencor International, Inc.
    Inventors: Ayrookaran J. Poulose, Volker Schellenberger, James T. Kellis, Jr., Christian Paech, Joanne Nadherny, Donald P. Naki, Katherine D. Collier, Robert M. Caldwell, André C. Baeck
  • Enterobacteriaceae fermentation strains
    Patent number: 6916646
    Abstract: Methods are provided for preparing improved fermentation strains of the family Enterobacteriaceae which comprise the steps of eliminating the cryptic plasmid from the progenitor strain thereby creating the improved strain. Methods for reducing the mobilization properties of resident plasmids in an Enterobacteriaceae strain containing a cryptic plasmid are also provided. The present invention provides the nucleic acid sequence of pS, a cryptic plasmid found in Pantoea which can be used to identify the cryptic plasmid in strains of Enterobacteriaceae.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: July 12, 2005
    Assignee: Genencor International, Inc.
    Inventors: Timothy Fowler, Stuart C. Causey
  • Mutant aprE promoter
    Patent number: 6911322
    Abstract: The present invention provides a mutant aprE promoter and methods for the production of a desired protein in a Bacillus host cell, which comprises the mutant aprE promoter. The present invention provides the sequence of a preferred aprE mutant promoter, which provided for a 100-fold increase in the production of a protein from Bacillus subtilis.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: June 28, 2005
    Assignee: Genencor International, Inc.
    Inventors: Fernando Valle, Eugenio Ferrari
  • Proteases from gram-positive organisms
    Patent number: 6911333
    Abstract: The present invention relates to the identification of novel serine proteases in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for the Bacillus subtilis serine proteases SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells further comprising nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides a cleaning composition comprising a serine protease of the present invention.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: June 28, 2005
    Assignee: Genencor International, Inc.
    Inventor: David A. Estell
  • Proteases from gram-positive organisms
    Patent number: 6905868
    Abstract: The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for Bacillus MP. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding MP. The present invention also provides host cells further comprising nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides cleaning compositions comprising an MP of the present invention.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: June 14, 2005
    Assignee: Genencor International, Inc.
    Inventor: David A. Estell
  • Proteins producing an altered immunogenic response and methods of making and using the same
    Patent number: 6897049
    Abstract: The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: May 24, 2005
    Assignee: Genencor International, Inc.
    Inventors: David A. Estell, Fiona A. Harding
  • Proteases from gram-positive organisms
    Patent number: 6881562
    Abstract: The present invention relates to the identification of novel serine proteases in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for the Bacillus subtilis serine proteases SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells further comprising nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides a cleaning composition comprising a serine protease of the present invention.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: April 19, 2005
    Assignee: Genencor International, Inc.
    Inventor: David A. Estell
  • Proteases from gram positive organisms
    Patent number: 6872807
    Abstract: The present invention relates to the identification of a novel metalloproteases in gram positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for the metalloprotease. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding the metalloprotease. The present invention provides host cells which further comprises a nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides cleaning compositions, animal feeds and compositions used to treat a textile that include the metalloprotease of the present invention.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: March 29, 2005
    Assignee: Genencor International, Inc.
    Inventor: David A. Estell
  • Particle with substituted polyvinyl alcohol coating
    Patent number: 6872696
    Abstract: The present invention provides an improved coating material for use with particles, such as enzyme granules, and the like. In particular, the present invention provides a modified PVA, as well as particles or granules that include such coating. The PVA is modified by substituting hydrophilic moieties for the hydroxyl or alcohol groups of the PVA. Substitution may be achieved with hydrophilic acids, amines, thiols, or combinations thereof.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: March 29, 2005
    Assignee: Genencor International, Inc.
    Inventors: Nathaniel T. Becker, Matthew J. Flynn, Mark S. Gebert
  • 2,5-diketo-L-gluconic acid reductases and methods of use
    Patent number: 6864075
    Abstract: Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described.
    Type: Grant
    Filed: April 17, 2003
    Date of Patent: March 8, 2005
    Assignee: Genencor International, Inc.
    Inventors: Mark Donnelly, William H. Eschenfeldt, Jonathan Trent
  • Proteases from gram-positive organisms
    Patent number: 6849440
    Abstract: The present invention relates to the identification of novel serine proteases in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for the Bacillus subtilis serine proteases SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells further comprising nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides a cleaning composition comprising a serine protease of the present invention.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: February 1, 2005
    Assignee: Genencor International, Inc.
    Inventor: David A. Estell
  • Enhanced secretion of a polypeptide by a microorganism
    Patent number: 6846653
    Abstract: Described herein are methods for the enhanced production of secreted proteins. The secretion of a protein of interest having a substantially non-polar carboxy tail is enhanced by the placement of charged amino acid residues at the carboxy terminus either by adding to the native peptide or by replacing, i.e., substituting, the terminal residues of the native peptide.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: January 25, 2005
    Assignee: Genencor International, Inc.
    Inventor: Marc Kolkman
  • Proteins producing an altered immunogenic response and methods of making and using the same
    Patent number: 6838269
    Abstract: The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions. Moreover, naturally occuring proteins are provided.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: January 4, 2005
    Assignee: Genencor International, Inc.
    Inventors: David A. Estell, Fiona A. Harding
  • Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
    Patent number: 6835550
    Abstract: The present invention relates to a novel improved protein mutant which produces low allergenic response in humans compared to the parent of that mutant. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: December 28, 2004
    Assignee: Genencor International, Inc.
    Inventors: David A. Estell, Fiona A. Harding
  • Proteases from gram-positive organisms
    Patent number: 6833261
    Abstract: The present invention relates to the identification of novel serine proteases in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for the Bacillus subtilis serine proteases SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells further comprising nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides a cleaning composition comprising a serine protease of the present invention.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: December 21, 2004
    Assignee: Genencor International, Inc.
    Inventor: David A. Estell
  • Proteases from gram-positive organisms
    Patent number: 6833265
    Abstract: The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for Bacillus (MP). The present invention also provides host cells having mutation or deletion of part or all of the gene encoding MP. The present invention also provides host cells further comprising nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides cleaning compositions comprising an MP of the present invention.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: December 21, 2004
    Assignee: Genencor International, Inc.
    Inventor: David A. Estell
  • Esterase enzymes, DNA encoding esterase enzymes and vectors and host cells incorporating same
    Patent number: 6828136
    Abstract: A novel DNA is provided which encodes an enzyme having esterolytic activity isolated from Aspergillus. Also provided for is a method of isolating DNA encoding an enzyme having esterolytic activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA and the use of the expressed esterase protein in feed as a supplement, in textiles for the finishing of such textiles prior to sale, in starch processing or production of foods such as baked bread.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: December 7, 2004
    Assignee: Genencor International, Inc.
    Inventors: William S. Borneman, Benjamin S. Bower