Patents Represented by Attorney Geoffrey G. Dellenbaugh
  • Patent number: 5196310
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 3, 1989
    Date of Patent: March 23, 1993
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Patent number: 4959458
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 31, 1984
    Date of Patent: September 25, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Patent number: 4798806
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 1, 1986
    Date of Patent: January 17, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Patent number: 4791111
    Abstract: Novel [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H -imidazoles and 1H-1,2,4-triazoles, having anti-microbial activity, compositions containing the same, and methods of inhibiting and/or eliminating the development of fungi and bacteria in warm-blooded animals suffering from diseases caused by these fungi and/or bacteria.
    Type: Grant
    Filed: October 16, 1986
    Date of Patent: December 13, 1988
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Jozef B. A. Thijssen, Alfonsus G. Knaeps
  • Patent number: 4784951
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: November 15, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Patent number: 4778887
    Abstract: The present invention is related with .alpha.-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneaceton itriles which are effective in destructing or preventing the growth of Protozoa in subjects suffering from such Protozoa.
    Type: Grant
    Filed: October 17, 1986
    Date of Patent: October 18, 1988
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Gustaaf M. Boeckx, Alfons H. M. Raeymaekers, Victor Sipido
  • Patent number: 4775636
    Abstract: A method for detecting and/or determining an agglomerate formed by the reaction between a specific binding agent and the corresponding acceptor substance according to the general methodology of blot overlay assays by using colloidal metal particles labelled components which may be visualized as a coloured signal at the surface of the blotting medium characteristric for the colloidal metal particles used or quantitatively determined following art-known spectrophotometric procedures such as densitometry.
    Type: Grant
    Filed: October 27, 1987
    Date of Patent: October 4, 1988
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Marc K. J. Moeremans, Guido F. T. Daneels, Jan R. De Mey
  • Patent number: 4775631
    Abstract: A method of detecting and localizing nucleic acids on polyamide supports which comprises contacting said supports with a suspension of colloidal metal particles whereupon the metal particles bind to the polyamide support and form a colored background against which the location where nucleic acids are present become visible as lighter spots. The method enables the mere qualitative localization of the nucleic acids and the quantitative determination thereof following art-known procedures.
    Type: Grant
    Filed: July 26, 1985
    Date of Patent: October 4, 1988
    Assignee: Janssen Pharmaceuitica, N.V.
    Inventor: Eric L. J. Saman
  • Patent number: 4770689
    Abstract: A method for controlling weeds preferably in the crops of useful plants by using a 1-methyl-1H-imidazole-5-carboxylic acid derivative; herbicidal compositions containing the same; 1-methyl-1H-imidazole-5-carboxylic acid derivatives.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: September 13, 1988
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jozef F. E. Van Gestel, William R. Lutz, Guy R. E. Van Lommen, Hanspeter Fischer, Marc F. J. Schroven, Rudolph C. Thummel
  • Patent number: 4767760
    Abstract: Novel 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-diones which are effective in destroying or preventing the growth of Protozoa in subjects suffering from such Protozoa.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: August 30, 1988
    Assignee: Janssen Pharmacuetica N.V.
    Inventors: Gustaaf M. Boeckx, Alfons H. M. Raeymaekers, Victor Sipido
  • Patent number: 4766125
    Abstract: Novel N-aryl-piperazinealkanamides, having particular substituents attached to one of the carbon atoms of the piperazine ring, which compounds are useful to protect hearts from myocardial injury caused by ischaemia, anoxia or hypoxia.
    Type: Grant
    Filed: March 29, 1982
    Date of Patent: August 23, 1988
    Assignee: Janssen Pharmaceutica N.V.
    Inventor: Georges Van Daele
  • Patent number: 4764604
    Abstract: This invention relates to .gamma.-cyclodextrin ethers and mixed ethers wherein the ether substituents are C.sub.1 -C.sub.6 alkyl, hydroxy C.sub.1 -C.sub.6 alkyl, carboxy C.sub.1 -C.sub.6 alkyl or (C.sub.1 -C.sub.6 alkyloxycarbonyl) C.sub.1 -C.sub.6 alkyl; provided that hydroxypropyl is not a sole substituent.
    Type: Grant
    Filed: February 27, 1986
    Date of Patent: August 16, 1988
    Assignee: Janssen Pharmaceutica N.V.
    Inventor: Bernd W. W. Muller
  • Patent number: 4760074
    Abstract: Novel N-(bicyclic heterocyclyl)-4-piperidinamines having antihistaminic and serotonin-antagonistic properties which are useful in the treatment of allergic diseases.
    Type: Grant
    Filed: November 21, 1985
    Date of Patent: July 26, 1988
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frans E. Janssens, Jozeph L. G. Torremans, Jozef F. Hens, Theophilus T. J. M. Van Offenwert
  • Patent number: 4752567
    Abstract: A method of visualizing individual submicroscopic metal particles by subjecting said particles to bright field or epi-polarization microscopy and enhancing the contrast of the image so obtained by electronic means.
    Type: Grant
    Filed: June 21, 1984
    Date of Patent: June 21, 1988
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Marc J. De Brabander, Gustaaf M. A. Geuens, Rony M. Nuydens, Marc K. J. J. Moeremans
  • Patent number: 4749690
    Abstract: A method for treating allergy by administration of the peptide thymopentin.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: June 7, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Gideon Goldstein
  • Patent number: 4746671
    Abstract: Novel [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters, compositions containing the same, and methods of treating clinical conditions related with the production of thromboxane A.sub.2, prostacyclin and/or prostaglandins D.sub.2, E.sub.2 and F.sub.2.alpha..
    Type: Grant
    Filed: July 23, 1986
    Date of Patent: May 24, 1988
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Eddy J. E. Freyne, Alfons H. M. Raeymaekers, Victor Sipido, Marc G. Venet
  • Patent number: 4743681
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 29, 1984
    Date of Patent: May 10, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Patent number: 4735942
    Abstract: Substituted [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3 dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having antimicrobial properties and being particularly useful in the treatment of vaginal candidosis.
    Type: Grant
    Filed: June 2, 1986
    Date of Patent: April 5, 1988
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Raymond A. Stokbroekx, Leo J. J. Backx
  • Patent number: 4728614
    Abstract: A stable mutant human T cell line is disclosed which secretes a high titer suppressor inducer factor. This suppressor inducer factor in turn induces production of a T cell suppressor factor which suppressed mitogen-induced T cell proliferation at high dilution. Also disclosed is a general method for mutating lymphoblastoid cell lines to yield mutants secreting enhanced levels of lymphokines.
    Type: Grant
    Filed: March 5, 1984
    Date of Patent: March 1, 1988
    Assignee: Ortho Pharmaceutical
    Inventor: Catherine Y. Lau
  • Patent number: 4713480
    Abstract: An amino-protected L-aspartic acid, such as t-butyloxycarbonyl-beta-benzyl-L-aspartic acid, is prepared by first forming the amino-protected compound in the presence of a tertiary amine base having a pK.sub.a value of about 9 to about 12, water, and a water-immiscible polar organic solvent so as to produce a non-aqueous solution containing a salt form of amino-blocked-beta-benzyl-L-aspartic acid. The thus produced non-aqueous solution is then isolated, or next acidified and treated further to ultimately recover therefrom the amino-protected L-aspartic acid in crystalline form.
    Type: Grant
    Filed: January 7, 1987
    Date of Patent: December 15, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: John M. Pascone