Patents Represented by Attorney George Dohmann
  • Patent number: 8222244
    Abstract: The present invention relates to the use of staurosporines derivatives for the preparation of a drug for the treatment of diseases involving deregulated FLT3 receptor tyrosine kinase activity, especially for the curative and/or prophylactic treatment of leukemias and myelodysplastic syndromes, and to a method of treating diseases involving deregulated FLT3 receptor tyrosine kinase activity.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: July 17, 2012
    Assignees: Novartis AG, Dana-Farber Cancer Institute Inc.
    Inventors: James D Griffin, Paul W Manley
  • Patent number: 8119649
    Abstract: The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Btk kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: February 21, 2012
    Assignees: Novartis AG, GSF-International Research Institute for Environment and Health, Board of Regents, The University of Texas system
    Inventors: Nicholas J Donato, Doriano Fabbro, Paul W Manley, Jurgen Mestan, Markus Warmuth, Michael Hallek, Moshe Talpaz, Ji Wu
  • Patent number: 5556828
    Abstract: Mixtures of a herbicidally effective amount of a haloacetamide of formula I ##STR1## and, to antagonize the herbicide, an antidotally effective amount of a compound of formula IIR--CHYCl (II)wherein R is defined herein, suitable for controlling weeds in crops of cultivated plants, particularly maize.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: September 17, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Jutta Glock, Elmar Kerber
  • Patent number: 5529974
    Abstract: Mixtures comprising a herbicidally effective amount of a pyridylsulfonylurea of formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and A are as defined in claim 1, and a herbicide-antagonistically effective amount of a sulfamoylphenylurea of formula II ##STR2## wherein R.sub.12 to R.sub.16 and A.sub.2 are as defined in claim 1, are very suitable for the control of weeds in crops of useful plants, especially maize.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 25, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Elmar Kerber
  • Patent number: 5428002
    Abstract: The invention relates to compounds of formula ##STR1## wherein W, X, Y.sup.1, Y.sup.2, Z, R.sup.1, R.sup.2 and R.sup.14 are as defined in the description, and to the preparation thereof, to weed control compositions and plant-growth-regulating compositions comprising such compounds as active ingredients, and to the use of the active ingredients or compositions for controlling weeds and for regulating plant growth.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: June 27, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Christoph Luthy, Jean-Pierre Obrecht
  • Patent number: 5407900
    Abstract: (Cyclopropyl-triazinyl- and cyclopropyl-pyrimidinyl-)pyridylsulfonylureas of formula I ##STR1## wherein R and R.sub.1 are each independently of the other hydrogen or methyl;R.sub.2 is methyl, methoxy or ethoxy; andE is nitrogen or the methine group;and the salts of those compounds, have good selective herbicidal properties. The preparation of those compounds and the use thereof as herbicidal active ingredients are described.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: April 18, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Fory, Rolf Schurter
  • Patent number: 5403814
    Abstract: N-pyridinesulfonyl-N'-pyrimidinyl- and -triazinyl-ureas of formula I ##STR1## wherein R.sub.1 is hydrogen or fluorine;or R.sub.1 together with R.sub.3 is a C.sub.2 -C.sub.4 alkylene chain;R.sub.3 is hydrogen, fluorine or C.sub.1 -C.sub.3 alkyl;R.sub.2 is hydrogen, fluorine or C.sub.1 -C.sub.3 alkyl;R.sub.4 is hydrogen, fluorine, chlorine or C.sub.1 -C.sub.3 alkyl;R.sub.5 is hydrogen, fluorine, chlorine, C.sub.1 -C.sub.3 alkyl, or C.sub.1 -C.sub.3 alkyl substituted by fluorine or chlorine;R.sub.a is hydrogen or halogen, or a C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or C.sub.1 -C.sub.4 alkylthio radical each of which may be unsubstituted or mono- or poly-substituted by halogen;R.sub.b is hydrogen or a C.sub.1 -C.sub.4 alkyl radical;X is C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl mono- to tri-substituted by halogen, C.sub.1 -C.sub.3 alkoxy, or C.sub.1 -C.sub.3 alkoxy mono- to tri-substituted by halogen;Y is halogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl mono- to tri-substituted by halogen, C.
    Type: Grant
    Filed: April 7, 1994
    Date of Patent: April 4, 1995
    Assignee: Ciba-Geigy Corporation
    Inventor: Werner Fory
  • Patent number: 5387694
    Abstract: The present invention relates to chromogenic methylenepyrrolines and processes and intermediates for their preparation and to their use.The chromogenic methylenepyrroline compounds according to the invention have the formula (I) defined in claim 1.These colour formers are suitable in particular for thermographic recording processes and produce intensive red, violet, blue or brown colourations. They are distinguished by the fact that they do not require any conventional electron-withdrawing acid colour developer.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: February 7, 1995
    Assignee: Ciba-Geigy Corporation
    Inventor: Davor Bedekovic
  • Patent number: 5096460
    Abstract: The invention relates to a dye mixture containing a dye of the formula ##STR1## in which R.sub.1 is methyl or ethyl and at least one dye of the formulae (2) and (3) ##STR2## in which D is substituted or unsubstituted phenyl, thiophenyl or benzothiazolyl, R.sub.2 is C.sub.1 -C.sub.8 alkyl, R.sub.3 is substituted or unsubstituted C.sub.1 -C.sub.8 alkyl, and R.sub.4 is hydrogen or C.sub.1 -C.sub.4 alkyl, and ##STR3## in which R.sub.5 is C.sub.1 -C.sub.4 alkyl. The dye mixture is distinguished by generally good properties, in particular by good exhaustion.
    Type: Grant
    Filed: November 19, 1990
    Date of Patent: March 17, 1992
    Assignee: Ciba-Geigy Corporation
    Inventor: Dieter Mausezahl