Abstract: Growth differentiation factor-14 (GDF-14) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-14 polypeptide and polynucleotide sequences.

Abstract: One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic.

Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue.

Abstract: The present invention provides a remote afterloader for moving a radiation source into and out of a catheter inserted in a tumor may include one or more radiation source cassettes, one or more motors, and a shielded container for storing the radiation source cassettes and the motor. Each radiation source cassette may include a radiation source wire having the radiation source connected to a treating end and a dummy source wire having a dummy source connected to a treating end. The motor advances and retracts the radiation source wire and the dummy source wire into and out of each radiation source cassette one at a time.

Abstract: Systems and methods are described for addressable field emission array (AFEA) chips. A method of operating an addressable field-emission array, includes: generating a plurality of electron beams from a pluralitly of emitters that compose the addressable field-emission array; and focusing at least one of the plurality of electron beams with an on-chip electrostatic focusing stack. The systems and methods provide advantages including the avoidance of space-charge blow-up.

Abstract: Methods, systems and devices are described relating to a chassis for front and back inserted modules. An apparatus includes a chassis including a first module bay and a second module bay, the first module bay and the second module bay together composing both a forward section and rearward section.

Abstract: The present invention includes a fluorescent compound that can detect an activity, such as an enzymatic activity, and exhibits quenching. The fluorescent compound can include a fluorescent protein, such as an Aequorea-related green fluorescent protein. The fluorescent compound can include a substrate site for an enzymatic activity such as a kinase activity, a phosphatase activity, a protease activity, and a glycosylase activity. The fluorescent compound of the present invention can be used to detect such enzymatic activities in samples, such as biological samples, including cells. The present invention also includes nucleic acids that encode the fluorescent compounds of the present inventions, and cells that include such nucleic acids or fluorescent compounds.

Abstract: Systems and methods are described for multi-link segmentation and reassembly for bonging multiple virtual circuits in an inverse multiplexing arrangement. A method includes: generating a plurality of multilink segmentation and reassembly sublayer cells at a first location; distributing the plurality of multilink segmentation and reassembly sublayer cells across a plurality of virtual circuits; transmitting the plurality of multilink segmentation and reassembly sublayer cells to a second location via the plurality of virtual circuits; and receiving the plurality of multilink segmentation and reassembly sublayer cells at the second location. An apparatus includes a multilink segmentation and reassembly sublayer transmitter, including: a source buffer; a multilink controller coupled to the source buffer; and a plurality of virtual circuits coupled to the multilink controller.

Abstract: A memory device includes a sense circuit comprising a sense amplifier, a reference sense circuit and a comparator. The sense amplifier detects a signal on a bit line associated with a column of memory cells in a memory array. The reference sense circuit detects a signal on a reference bit line associated with a column of reference cells in the memory array. The comparator compares the outputs of the sense amplifier and the reference sense circuit and provides a signal indicative of the contents of the read memory cell. In response to a transition of an address, the bit line and the reference bit line are precharged prior to reading of the memory cell. The reference sense circuit includes a selectable load that is disabled during the initial time after the address transition so that the bit line and the reference bit line rises substantially identically and then enabled to allow the reference bit line to settle to a steady state.

Abstract: Disclosed are peptides related to human TGF-&agr;, having TGF-&agr; biological activity, which are useful for many of the indications that full-length TGF-&agr; polypeptide is useful. Also provided are methods of use of such peptides, as well as human TGF-&agr; and biologically related polypeptides. For example, methods for treating or preventing cachexia in subjects are provided as well as methods for stimulating hematopoiesis in patients undergoing cytotoxic chemotherapy. In addition, the use of TGF-&agr; related peptides to related neurodengenerative diseases is also provided. Methods of the invention also provide protection for patients undergoing cytotoxic therapy from side effects such as gastrointestinal (GI) mucositis.

Abstract: A memory alias adapter, coupled to a processors memory bus, monitors processor memory accesses. Whenever a memory access corresponds to shared memory, rather than memory local to the processor, the adapter constructs a memory request message, and transmits the message over a network link to a shared memory unit. The shared memory unit performs the shared memory access and issues a response message over the network link. The memory alias adapter accepts the response message, and completes processor's memory access on the memory bus.

Abstract: In a computer system constituted by a portable computer and a desk station used to expand the function of the portable computer, the portable computer has a communication connector used for communication with the desk station, in addition to a connector for connecting a system bus in the portable computer to the desk station. Temperature control in the portable computer is also executed. The computer may include a one-chip controller that includes an element having a characteristic that varies with temperature and further includes a dedicated pin electrically connected to the element. The element may be mounted on a portion of an integrated circuit substrate. The dedicated pin may be provided on a portion of a connection pin arrangement.

Abstract: A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.

Abstract: Growth differentiation factor-15 (GDF-15) polynucleotide sequence and amino acid sequence are provided herein. Also described are diagnostic and therapeutic methods of using GDF-15 polypeptide and polynucleotide sequences.

Abstract: The present invention is based on the discovery of a simplified assay for identifying modulators of ubiquitin ligase activity. This assay allows detection of compounds that affect ubiquitination and thus, cell cycle regulation in cells. An increase in ubiquitination, in comparison to a test sample lacking a test compound, indicates a stimulation of activity, whereas a reduction in ubiquitination indicates an inhibitor of activity. Also disclosed herein are methods of identifying proteins having ubiquitin ligase activity, methods of identifying substrates for ubiquitination, methods for identifying an activity relationship between a particular ubiquitin ligase and a particular ubiquitin conjugating enzyme, and chimeric proteins comprising a ubiquitin conjugating enzyme and a ubiquitination substrate, which are useful in all of the disclosed methods.

Abstract: Catalase enzymes derived from bacteria from the genera Alcaligenes (Deleya) and Microscilla are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized to destroy or detect hydrogen peroxide, e.g., in production of glyoxylic acid and in glucose sensors, and in processes where hydrogen peroxide is used as a bleaching or antibacterial agent, e.g. in contact lens cleaning, in bleaching steps in pulp and paper preparation and in the pasteurization of dairy products.

Abstract: This invention provides an optical probe useful as an optical probe or sensor of post translational type modifications, such as phosphorylation. The invention comprises a polypeptide moiety, which contains a recognition motif for a post translational type activity and a protease site, which is coupled to a probe moiety. Modification of the polypeptide, by the post translational type activity, results in a modulation of the rate at which a protease cleaves the polypeptide which is sensed by a measurable change in at least one optical property of the optical probe upon cleavage. The present invention also includes a recombinant nucleic acid molecule that encodes an optical probe and a vector and host cell or library of cells that include the recombinant nucleic acid molecule. The optical probe can be used in methods to determine whether a sample, including a cell or a sample from an organism, contains a post-translational type modification activity.

Abstract: A nonvolatile semiconductor memory includes a plurality of memory cells arranged in columns and rows, a plurality of word lines, a plurality of bit lines, a plurality of output buffers, a plurality of page latches 18L, and a plurality of Quick Current Level Translators (QCLT). Each QCLT is connected to and is shared by a plurality of bit lines (32 in the preferred embodiment) through a first column decoder 44/46U and is also connected to a plurality of page latches through a second column decoder 46L. Each page latch is connected to one corresponding output buffer through a third column decoder circuit 38/40/42. The page latches are grouped in a plurality of sub-pages. The QCLT performs high speed and high accuracy current-mode comparison and converts the result of comparison into binary codes. These codes are stored in Q-latches 36U-2. The QCLT functions as a current-mode analog-to-digital converter (ADC) which converts the memory cell current to binary codes.

Abstract: The invention relates to a method for transferring, for instance, a biological material arranged in a given pattern, whereby the biological material is brought into contact with needles placed on the head of a robot and the biological material is transferred to a support, whereby the needles are hard metal needles fitted with a biocompatible coating. The biocompatible coating preferably consists of metal-nitrogen compounds. Preferably, an anticorrosion coating is applied underneath the biocompatible coating. Once the biological material has been arranged in a given pattern, the needles mounted on the robot head are arranged according to the same pattern. Preferably, the pattern corresponds to the pattern of the arrangement of microtitre plate wells. The invention also relates to a robot head fitted with the inventive hard metal needles. Said robot head particularly forms part of a picking and/or a spotting robot.

Abstract: A support assembly including first and second mounting brackets each having a mounting surface for attachment to a bottom surface of a desktop, first and second support arms pivotally attached to the first and second mounting brackets respectively to define first and second pivot axes, and a computer keyboard platform having a top support surface and a bottom surface. The first and second support arms rotate in a single plane about the first and second pivot axes respectively. The first and second support arms are pivotally attached to the bottom surface of the platform to define third and fourth pivot axes respectively. The support arms are rotatable relative to the platform in the single plane about the third and fourth pivot axes respectively.