Abstract: This disclosure describes a method for constructing targeting agent drug conjugates from the family of methyltrithio antibacterial and antitumor agents.
Type:
Grant
Filed:
October 26, 1994
Date of Patent:
June 23, 1998
Assignee:
American Cyanamid Company
Inventors:
William James McGahren, Martin Leon Sassiver, George A. Ellestad, Philip R. Hamann, Lois M. Hinman, Janis Upeslacis
Abstract: A process is described for producing substituted disulfide analogs of the family of antibacterial and antitumor agents known collectively as the LL-E33288 complex.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
June 23, 1998
Assignee:
American Cyanamid Company
Inventors:
William James McGahren, Martin Leon Sassiver, George A. Ellestad
Abstract: This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
April 14, 1998
Assignee:
American Cyanamid Company
Inventors:
Philip Ross Hamann, Lois Hinman, Irwin Hollander, Ryan Holcomb, William Hallett, Hwei-Ru Tsou, Martin J. Weiss