Patents Represented by Law Firm Hammond & Littell, Weissenberger & Dippert
  • Patent number: 4643993
    Abstract: Compounds of the formula ##STR1## wherein Het is a heterocycle containing 2 to 3 nitrogen atoms;R is hydrogen, lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen;Y is --SO.sub.3 H or ##STR2## R" is alkyl of 1 to 3 carbon atoms; and R' is straight or branched alkyl which may contain a heteroatom such as sulfur, oxygen or nitrogen; straight or branched alkenyl; cycloalkyl; alkyl-cycloalkyl; aryl; or aralkyl optionally substituted by lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen; tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics and gastric acid secretion inhibitors.
    Type: Grant
    Filed: May 18, 1983
    Date of Patent: February 17, 1987
    Assignee: Istituto de Angeli S.p.A.
    Inventors: Enzo Cereda, Arturo Donetti, Antonio Giachetti, Piero del Soldato
  • Patent number: 4639438
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 which may be identical to or different from each other, are each straight or branched alkyl of 1 to 3 carbon atoms;R.sub.3 is alkyl of 1 to 8 carbon atoms;X is sulfur or oxygen;Y is chlorine, bromine or fluorine; andn is 1 or 2.The compounds are useful as pesticides.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: January 27, 1987
    Assignee: Celamerck GmbH & Co. KG
    Inventors: Richard Sehring, Wolfgang Buck, Ricarda Prokic-Immel, Sigmund Lust
  • Patent number: 4636510
    Abstract: The invention relates to 4-phenyl-tetrahydro-furano-pyridines of the formulas ##STR1## wherein R.sup.1 to R.sup.5 are variously defined. The compounds of the invention are intended to be used as anti-depressants with, in particular, thymoleptic and central-stimulant properties.
    Type: Grant
    Filed: April 19, 1984
    Date of Patent: January 13, 1987
    Assignee: Boehringer Ingelheim KG
    Inventors: Claus Schneider, Gerhard Walther, Karl-Heinz Weber, Wolf D. Bechtel, Karin Boke-Kuhn
  • Patent number: 4629733
    Abstract: The present invention relates to novel indolinones of the general formula ##STR1## wherein R represents an aryl group having from 6 to 10 carbon atoms, unsubstituted or mono- or disubstituted by alkyl groups having from 1 to 5 carbon atoms, hydroxyl groups, alkoxy groups having from 1 to 3 carbon atoms, or halogen atoms, whereby the substituents may be the same or different and whereby the phenyl nucleus of the aryl group may also be substituted by an amino group, a hydroxyl group, or an alkanoylamino group with altogether from 1 to 3 carbon atoms; an aryl group having from 6 to 10 carbon atoms, substituted by 3 or 4 alkyl groups having from 1 to 5 carbon atoms each; a phenyl group substituted by a phenyl, halogenphenyl, or cycloalkyl group with 5 to 7 carbon atoms; an aralkyl group having from 7 to 11 carbon atoms; or a pentamethylphenyl, pyridyl, or quinolyl group; m represents the number 0, 1, or 2; and n represents the number 2, 3, 4, 5, or 6.
    Type: Grant
    Filed: July 27, 1984
    Date of Patent: December 16, 1986
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Erich Muller, Josef Nickl, Josef Roch, Berthold Narr
  • Patent number: 4624960
    Abstract: The invention relates to the use of a substance as a sedative with an analgesic and bradycardiac effect in warm-blooded animals. The possible applications are, for example, in the field of veterinary medicine for general tranquilizing and for producing analgesia.
    Type: Grant
    Filed: October 11, 1985
    Date of Patent: November 25, 1986
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Otto Kern, Franz Wilhelm
  • Patent number: 4622340
    Abstract: This invention relates to compounds of the formula ##STR1## Z' is chlorine or fluorine, with the proviso that Z' is chlorine when Q is the moiety of Formula III. The invention also relates to the preparation of the compounds, their use in controlling animal pests in plant protection, and pesticidal agents comprising the compounds as active ingredients.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: November 11, 1986
    Assignee: Celamerck GmbH & Co., KG
    Inventors: Heinz-Manfred Becher, Ricarda Prokic-Immel, Walter Wirtz
  • Patent number: 4617949
    Abstract: This invention relates to an apparatus for applying materials to the scalp. More specifically, this invention relates to a scalp applicator means comprising a hollow body and an applicator means, said applicator means comprising two forked prongs, each of which prongs has at its end at least one outlet or spray opening, the outlets or spray openings on each prong being positioned laterally on the sides of the prongs away from each other.
    Type: Grant
    Filed: October 11, 1984
    Date of Patent: October 21, 1986
    Assignee: Basotherm GmbH
    Inventor: Ernest Hofmann-Igl
  • Patent number: 4616018
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methylpyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; and,R.sub.
    Type: Grant
    Filed: June 27, 1985
    Date of Patent: October 7, 1986
    Assignee: Karl Thomae GmbH
    Inventors: Norbert Hauel, Volkhard Austel, Joachim Heider, Manfred Reiffen, Willi Diederen, Walter Haarman
  • Patent number: 4616011
    Abstract: This invention relates to novel indole derivatives of the formula ##STR1## wherein A represents a --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## group and B represents a methylene, carbonyl, or thiocarbonyl group or A represents a --CO--CO-- or ##STR3## group and B represents a methylene group, E represents an alkylene group or a 2-hydroxy-n-propylene, 2-hydroxy-n-butylene, or 3-hydroxy-n-butylene group,G represents an alkylene group,R.sub.1 represents a hydrogen, chlorine, or bromine atom or a trifluoromethyl, nitro, amino, alkylamino, dialkylamino, alkyl, hydroxyl, alkoxy, or phenylalkoxy group,R.sub.2 represents a hydrogen, chlorine, or bromine atom or a hydroxyl, alkoxy, phenylalkoxy, or alkyl group orR.sub.1 and R.sub.2 together represent an alkylenedioxy group,R.sub.3 represents a hydrogen, chlorine, or bromine atom or an alkyl group,R.sub.4 represents a hydrogen atom or an alkyl or phenylalkyl group,R.sub.
    Type: Grant
    Filed: November 26, 1984
    Date of Patent: October 7, 1986
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Manfred Reiffen, Joachim Heider, Volkhard Austel, Norbert Hauel, Walter Kobinger, Christian Lillie
  • Patent number: 4613325
    Abstract: A flow rate sensing device, particularly for use in regulating the rate of flow in a system for parenteral administration of liquids to patients. The liquid emerges from a storage reservoir and is fed into a housing through an upstream flow passage portion and then is made to pass through a narrow throat passage wherein the velocity of the liquid increases while its pressure decreases. The liquid then emerges into a downstream flow through passage and flows through an outlet from the housing. In an intravenous fluid administration system, the housing outlet is connected to a terminal tubing section and an intravenous needle. A pressure transducer, consisting of two chambers separated by a resilient deformable diaphragm, has its upstream chamber in fluid and pressure communication with the upstream flow path portion and its downstream chamber in fluid and pressure communication with the flow emerging from the throat passage.
    Type: Grant
    Filed: December 22, 1983
    Date of Patent: September 23, 1986
    Inventor: Lawrence M. Abrams
  • Patent number: 4608995
    Abstract: An arrangement for the non-invasive determination of the minute volume Q of the heart is arranged to determine the amount of a sufficiently soluble gas, e.g. carbon dioxide or nitrous oxide, present in the blood, prior to and subsequent to the passage of the blood through the heart. The expired and inspired gases are separated from one another with each breath taken. Transducers feed respective devices for determining the gas content of the respiration gas, and the magnitude of the expiration gas flow and the inspiration gas flow. These devices are controlled by a microprocessor, which is programmed to supply gas from a gas source, to meter the gas during a subsequent inspiration cycle, and to control an indicator for the Q-value. The gas is controlled in a manner such that the gas-content of the lungs is changed in accordance with a given program. The Q-value is calculated for pairs of respiration cycles in accordance with the formula: ##EQU1## in which V.sub.
    Type: Grant
    Filed: August 14, 1984
    Date of Patent: September 2, 1986
    Assignee: Karolinska Institutet Institutionen for Medicinsk Teknik
    Inventors: Dag Linnarsson, Hans Larsson
  • Patent number: 4609672
    Abstract: The invention relates to a compound of the formula ##STR1## wherein R.sub.1 is a linear or branched alkyl of 4 to 20 carbon atoms;R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or a bivalent radical --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.n --, where n is an integer from 3 to 5, inclusive, and the free bonds of said bivalent radical are attached to adjacent carbon atoms of the phenyl ring; andR.sub.3 is hydrogen or alkyl of 1 to 3 carbon atoms;R.sub.4 is alkyl of 1 to 3 carbon atoms; orR.sub.3 and R.sub.4, together with each other, are --(CH.sub.2).sub.p --, where p is an integer from 4 to 6, inclusive,or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.
    Type: Grant
    Filed: June 25, 1984
    Date of Patent: September 2, 1986
    Assignee: C. H. Boehringer Sohn
    Inventors: Herbert Koppe, Werner Kummer, Helmut Stahle, Gojko Muacevic, Werner Traunecker
  • Patent number: 4608377
    Abstract: The invention herein relates to novel quaternary 6,11-dihydro-dibenzo-[b,e]-thiepine-11-N-alkylnorscopine ethers, the preparation thereof, and their use as spasmolytics or bronchospasmolytics.
    Type: Grant
    Filed: June 25, 1984
    Date of Patent: August 26, 1986
    Assignee: Boehringer Ingelheim KG
    Inventors: Rolf Banholzer, Rudolf Bauer
  • Patent number: 4604468
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen; alkyl of 1 to 5 carbon atoms; or optionally substituted aralkyl or 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
    Type: Grant
    Filed: July 25, 1984
    Date of Patent: August 5, 1986
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Herbert Koppe, Anton Mentrup, Ernst-Otto Renth, Kurt Schromm, Wolfgang Hoefke, Gojko Muaceic
  • Patent number: 4601442
    Abstract: Unmanned missile with strongly backswept wing unit, in particular delta wings, which is transported in a container and is launched from the container by means of an auxiliary drive after release of a lock, and which during cruise flight is drivable by a propeller engine, lateral force surfaces (25) being deployable for stabilization of the missile during cruise flight, from retraction spaces (26) in the region of the wing root of the delta wings, and further a friction clutch (64, 65) is provided at the missile which, without supply of energy from the outside, couples the standing propeller 6 with the drive motor (7) running in the container, after leaving the container.
    Type: Grant
    Filed: October 25, 1983
    Date of Patent: July 22, 1986
    Assignee: Dornier GmbH
    Inventors: Franz Friedel, Werner Fruhauf, Gunter Harms, Georg Heise, Heinrich Lukewille
  • Patent number: 4596705
    Abstract: This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol.
    Type: Grant
    Filed: October 7, 1983
    Date of Patent: June 24, 1986
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Gottfried Schepky, Rolf Brickl, Peter Gruber, Jochen Schmid, Ursula Springmeier
  • Patent number: 4595782
    Abstract: The present invention is for a process for the preparation of alkali metal salts of acyl cyanamides, especially those of aliphatic carboxylic acids by reacting carboxylic acid esters of lower alcohols with monoalkali metal cyanamides. The reaction results in a process which is simple and efficient and one which can be used in commercial scale batch or continuous operations.
    Type: Grant
    Filed: November 14, 1984
    Date of Patent: June 17, 1986
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Christian Hase, Horst Baumann, Franz-Josef Carduck, Hubert Pawelczyk
  • Patent number: 4595587
    Abstract: A novel divisible delayed release pharmaceutical tablet, wherein the rate of release of active ingredient is independent of the size and nature of the total surface area, and the fragments of which have the same characteristics of release of active ingredient as the undivided tablet.
    Type: Grant
    Filed: July 3, 1985
    Date of Patent: June 17, 1986
    Assignee: Boehringer Ingelheim KG
    Inventors: Bernd Zierenberg, Arun R. Gupte
  • Patent number: 4591452
    Abstract: This invention relates to a process for preparing free-flowing stabilizer and lubricant compositions for halogenated polymers comprising combining two or more lubricant and stabilizer components to form a mixture of powdered compounds, which mixture consists at least partly of organic compounds and lubricants and stabilizers solid at room temperature, and intensely fluid-mixing said mixture together with from about 0.2 to 5 parts by weight, per 100 parts by weight of the mixture, of an organic lubricant for halogenated polymers that is liquid at room temperature, the process being carried out so that melting or softening of the powdered compounds does not occur. The organic lubricant liquid at room temperature is selected from the group consisting of the 2-ethylhexyl, isononyl, isodecyl, isotridecyl, and isooctadecyl esters of 2-ethylhexanoic, isononanoic, isodecanoic, isotridecanoic, or isooctadecanoic acid or of a fatty acid having from 16 to 18 carbon atoms or a mixture thereof, such as stearic acid.
    Type: Grant
    Filed: April 1, 1983
    Date of Patent: May 27, 1986
    Assignee: Neynaber Chemie GmbH
    Inventors: Kurt Worschech, Peter Wedl, Frido Loffelholz
  • Patent number: D285343
    Type: Grant
    Filed: July 29, 1983
    Date of Patent: August 26, 1986
    Assignee: Ulla Anette Duarte-Martins
    Inventor: Herminio Duarte-Martins, Jr.