Patents Represented by Law Firm Hammond & Littell, Weissenberger & Dippert
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Patent number: 4643993Abstract: Compounds of the formula ##STR1## wherein Het is a heterocycle containing 2 to 3 nitrogen atoms;R is hydrogen, lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen;Y is --SO.sub.3 H or ##STR2## R" is alkyl of 1 to 3 carbon atoms; and R' is straight or branched alkyl which may contain a heteroatom such as sulfur, oxygen or nitrogen; straight or branched alkenyl; cycloalkyl; alkyl-cycloalkyl; aryl; or aralkyl optionally substituted by lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen; tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics and gastric acid secretion inhibitors.Type: GrantFiled: May 18, 1983Date of Patent: February 17, 1987Assignee: Istituto de Angeli S.p.A.Inventors: Enzo Cereda, Arturo Donetti, Antonio Giachetti, Piero del Soldato
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Patent number: 4639438Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 which may be identical to or different from each other, are each straight or branched alkyl of 1 to 3 carbon atoms;R.sub.3 is alkyl of 1 to 8 carbon atoms;X is sulfur or oxygen;Y is chlorine, bromine or fluorine; andn is 1 or 2.The compounds are useful as pesticides.Type: GrantFiled: March 12, 1986Date of Patent: January 27, 1987Assignee: Celamerck GmbH & Co. KGInventors: Richard Sehring, Wolfgang Buck, Ricarda Prokic-Immel, Sigmund Lust
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4-phenyl-tetrahydro-furano-pyridines and anti-depressant pharmaceutical compositions containing same
Patent number: 4636510Abstract: The invention relates to 4-phenyl-tetrahydro-furano-pyridines of the formulas ##STR1## wherein R.sup.1 to R.sup.5 are variously defined. The compounds of the invention are intended to be used as anti-depressants with, in particular, thymoleptic and central-stimulant properties.Type: GrantFiled: April 19, 1984Date of Patent: January 13, 1987Assignee: Boehringer Ingelheim KGInventors: Claus Schneider, Gerhard Walther, Karl-Heinz Weber, Wolf D. Bechtel, Karin Boke-Kuhn -
Patent number: 4629733Abstract: The present invention relates to novel indolinones of the general formula ##STR1## wherein R represents an aryl group having from 6 to 10 carbon atoms, unsubstituted or mono- or disubstituted by alkyl groups having from 1 to 5 carbon atoms, hydroxyl groups, alkoxy groups having from 1 to 3 carbon atoms, or halogen atoms, whereby the substituents may be the same or different and whereby the phenyl nucleus of the aryl group may also be substituted by an amino group, a hydroxyl group, or an alkanoylamino group with altogether from 1 to 3 carbon atoms; an aryl group having from 6 to 10 carbon atoms, substituted by 3 or 4 alkyl groups having from 1 to 5 carbon atoms each; a phenyl group substituted by a phenyl, halogenphenyl, or cycloalkyl group with 5 to 7 carbon atoms; an aralkyl group having from 7 to 11 carbon atoms; or a pentamethylphenyl, pyridyl, or quinolyl group; m represents the number 0, 1, or 2; and n represents the number 2, 3, 4, 5, or 6.Type: GrantFiled: July 27, 1984Date of Patent: December 16, 1986Assignee: Dr. Karl Thomae GmbHInventors: Erich Muller, Josef Nickl, Josef Roch, Berthold Narr
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Patent number: 4624960Abstract: The invention relates to the use of a substance as a sedative with an analgesic and bradycardiac effect in warm-blooded animals. The possible applications are, for example, in the field of veterinary medicine for general tranquilizing and for producing analgesia.Type: GrantFiled: October 11, 1985Date of Patent: November 25, 1986Assignee: Boehringer Ingelheim Vetmedica GmbHInventors: Otto Kern, Franz Wilhelm
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Patent number: 4622340Abstract: This invention relates to compounds of the formula ##STR1## Z' is chlorine or fluorine, with the proviso that Z' is chlorine when Q is the moiety of Formula III. The invention also relates to the preparation of the compounds, their use in controlling animal pests in plant protection, and pesticidal agents comprising the compounds as active ingredients.Type: GrantFiled: April 26, 1984Date of Patent: November 11, 1986Assignee: Celamerck GmbH & Co., KGInventors: Heinz-Manfred Becher, Ricarda Prokic-Immel, Walter Wirtz
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Patent number: 4617949Abstract: This invention relates to an apparatus for applying materials to the scalp. More specifically, this invention relates to a scalp applicator means comprising a hollow body and an applicator means, said applicator means comprising two forked prongs, each of which prongs has at its end at least one outlet or spray opening, the outlets or spray openings on each prong being positioned laterally on the sides of the prongs away from each other.Type: GrantFiled: October 11, 1984Date of Patent: October 21, 1986Assignee: Basotherm GmbHInventor: Ernest Hofmann-Igl
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Patent number: 4616018Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methylpyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; and,R.sub.Type: GrantFiled: June 27, 1985Date of Patent: October 7, 1986Assignee: Karl Thomae GmbHInventors: Norbert Hauel, Volkhard Austel, Joachim Heider, Manfred Reiffen, Willi Diederen, Walter Haarman
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Patent number: 4616011Abstract: This invention relates to novel indole derivatives of the formula ##STR1## wherein A represents a --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## group and B represents a methylene, carbonyl, or thiocarbonyl group or A represents a --CO--CO-- or ##STR3## group and B represents a methylene group, E represents an alkylene group or a 2-hydroxy-n-propylene, 2-hydroxy-n-butylene, or 3-hydroxy-n-butylene group,G represents an alkylene group,R.sub.1 represents a hydrogen, chlorine, or bromine atom or a trifluoromethyl, nitro, amino, alkylamino, dialkylamino, alkyl, hydroxyl, alkoxy, or phenylalkoxy group,R.sub.2 represents a hydrogen, chlorine, or bromine atom or a hydroxyl, alkoxy, phenylalkoxy, or alkyl group orR.sub.1 and R.sub.2 together represent an alkylenedioxy group,R.sub.3 represents a hydrogen, chlorine, or bromine atom or an alkyl group,R.sub.4 represents a hydrogen atom or an alkyl or phenylalkyl group,R.sub.Type: GrantFiled: November 26, 1984Date of Patent: October 7, 1986Assignee: Dr. Karl Thomae GmbHInventors: Manfred Reiffen, Joachim Heider, Volkhard Austel, Norbert Hauel, Walter Kobinger, Christian Lillie
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Patent number: 4613325Abstract: A flow rate sensing device, particularly for use in regulating the rate of flow in a system for parenteral administration of liquids to patients. The liquid emerges from a storage reservoir and is fed into a housing through an upstream flow passage portion and then is made to pass through a narrow throat passage wherein the velocity of the liquid increases while its pressure decreases. The liquid then emerges into a downstream flow through passage and flows through an outlet from the housing. In an intravenous fluid administration system, the housing outlet is connected to a terminal tubing section and an intravenous needle. A pressure transducer, consisting of two chambers separated by a resilient deformable diaphragm, has its upstream chamber in fluid and pressure communication with the upstream flow path portion and its downstream chamber in fluid and pressure communication with the flow emerging from the throat passage.Type: GrantFiled: December 22, 1983Date of Patent: September 23, 1986Inventor: Lawrence M. Abrams
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Patent number: 4608995Abstract: An arrangement for the non-invasive determination of the minute volume Q of the heart is arranged to determine the amount of a sufficiently soluble gas, e.g. carbon dioxide or nitrous oxide, present in the blood, prior to and subsequent to the passage of the blood through the heart. The expired and inspired gases are separated from one another with each breath taken. Transducers feed respective devices for determining the gas content of the respiration gas, and the magnitude of the expiration gas flow and the inspiration gas flow. These devices are controlled by a microprocessor, which is programmed to supply gas from a gas source, to meter the gas during a subsequent inspiration cycle, and to control an indicator for the Q-value. The gas is controlled in a manner such that the gas-content of the lungs is changed in accordance with a given program. The Q-value is calculated for pairs of respiration cycles in accordance with the formula: ##EQU1## in which V.sub.Type: GrantFiled: August 14, 1984Date of Patent: September 2, 1986Assignee: Karolinska Institutet Institutionen for Medicinsk TeknikInventors: Dag Linnarsson, Hans Larsson
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Patent number: 4609672Abstract: The invention relates to a compound of the formula ##STR1## wherein R.sub.1 is a linear or branched alkyl of 4 to 20 carbon atoms;R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or a bivalent radical --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.n --, where n is an integer from 3 to 5, inclusive, and the free bonds of said bivalent radical are attached to adjacent carbon atoms of the phenyl ring; andR.sub.3 is hydrogen or alkyl of 1 to 3 carbon atoms;R.sub.4 is alkyl of 1 to 3 carbon atoms; orR.sub.3 and R.sub.4, together with each other, are --(CH.sub.2).sub.p --, where p is an integer from 4 to 6, inclusive,or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.Type: GrantFiled: June 25, 1984Date of Patent: September 2, 1986Assignee: C. H. Boehringer SohnInventors: Herbert Koppe, Werner Kummer, Helmut Stahle, Gojko Muacevic, Werner Traunecker
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Patent number: 4608377Abstract: The invention herein relates to novel quaternary 6,11-dihydro-dibenzo-[b,e]-thiepine-11-N-alkylnorscopine ethers, the preparation thereof, and their use as spasmolytics or bronchospasmolytics.Type: GrantFiled: June 25, 1984Date of Patent: August 26, 1986Assignee: Boehringer Ingelheim KGInventors: Rolf Banholzer, Rudolf Bauer
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Patent number: 4604468Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen; alkyl of 1 to 5 carbon atoms; or optionally substituted aralkyl or 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.Type: GrantFiled: July 25, 1984Date of Patent: August 5, 1986Assignee: Boehringer Ingelheim International GmbHInventors: Herbert Koppe, Anton Mentrup, Ernst-Otto Renth, Kurt Schromm, Wolfgang Hoefke, Gojko Muaceic
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Patent number: 4601442Abstract: Unmanned missile with strongly backswept wing unit, in particular delta wings, which is transported in a container and is launched from the container by means of an auxiliary drive after release of a lock, and which during cruise flight is drivable by a propeller engine, lateral force surfaces (25) being deployable for stabilization of the missile during cruise flight, from retraction spaces (26) in the region of the wing root of the delta wings, and further a friction clutch (64, 65) is provided at the missile which, without supply of energy from the outside, couples the standing propeller 6 with the drive motor (7) running in the container, after leaving the container.Type: GrantFiled: October 25, 1983Date of Patent: July 22, 1986Assignee: Dornier GmbHInventors: Franz Friedel, Werner Fruhauf, Gunter Harms, Georg Heise, Heinrich Lukewille
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Patent number: 4596705Abstract: This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol.Type: GrantFiled: October 7, 1983Date of Patent: June 24, 1986Assignee: Dr. Karl Thomae GmbHInventors: Gottfried Schepky, Rolf Brickl, Peter Gruber, Jochen Schmid, Ursula Springmeier
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Patent number: 4595782Abstract: The present invention is for a process for the preparation of alkali metal salts of acyl cyanamides, especially those of aliphatic carboxylic acids by reacting carboxylic acid esters of lower alcohols with monoalkali metal cyanamides. The reaction results in a process which is simple and efficient and one which can be used in commercial scale batch or continuous operations.Type: GrantFiled: November 14, 1984Date of Patent: June 17, 1986Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Christian Hase, Horst Baumann, Franz-Josef Carduck, Hubert Pawelczyk
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Patent number: 4595587Abstract: A novel divisible delayed release pharmaceutical tablet, wherein the rate of release of active ingredient is independent of the size and nature of the total surface area, and the fragments of which have the same characteristics of release of active ingredient as the undivided tablet.Type: GrantFiled: July 3, 1985Date of Patent: June 17, 1986Assignee: Boehringer Ingelheim KGInventors: Bernd Zierenberg, Arun R. Gupte
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Patent number: 4591452Abstract: This invention relates to a process for preparing free-flowing stabilizer and lubricant compositions for halogenated polymers comprising combining two or more lubricant and stabilizer components to form a mixture of powdered compounds, which mixture consists at least partly of organic compounds and lubricants and stabilizers solid at room temperature, and intensely fluid-mixing said mixture together with from about 0.2 to 5 parts by weight, per 100 parts by weight of the mixture, of an organic lubricant for halogenated polymers that is liquid at room temperature, the process being carried out so that melting or softening of the powdered compounds does not occur. The organic lubricant liquid at room temperature is selected from the group consisting of the 2-ethylhexyl, isononyl, isodecyl, isotridecyl, and isooctadecyl esters of 2-ethylhexanoic, isononanoic, isodecanoic, isotridecanoic, or isooctadecanoic acid or of a fatty acid having from 16 to 18 carbon atoms or a mixture thereof, such as stearic acid.Type: GrantFiled: April 1, 1983Date of Patent: May 27, 1986Assignee: Neynaber Chemie GmbHInventors: Kurt Worschech, Peter Wedl, Frido Loffelholz
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Patent number: D285343Type: GrantFiled: July 29, 1983Date of Patent: August 26, 1986Assignee: Ulla Anette Duarte-MartinsInventor: Herminio Duarte-Martins, Jr.