Abstract: This invention is directed to a nail shielding device for use in applying a formaldehyde-containing liquid nail-hardening composition to human nails while protecting the cuticle and surrounding soft skin tissue from contact with said liquid compositions. The shielding device consists of an integral device having a forward end which is placed under the white tip of the nail, side and bottom portions which cover skin adjacent to the side edges of the nail and the bottom portion of the finger, a rear portion to cover the cuticle and skin to the rear of the cuticle, and two transverse apertures between the forward and rearward edges.
Abstract: Compounds of the formula ##STR1## wherein A is ##STR2## and R is hydrogen, alkyl of 1 to 5 carbon atoms, alkanoyl of 1 to 5 carbon atoms, alkenyl of 3 to 5 carbon atoms, (alkoxy of 1 to 4 carbon atoms)carbonyl, or aralkyl of 7 to 11 carbon atoms optionally halo-substituted,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.
Type:
Grant
Filed:
September 12, 1984
Date of Patent:
March 11, 1986
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Robert Sauter, Gerhart Griss, deceased, Wolfgang Grell, Rudolf Hurnaus, Walter Kobinger, Ludwig Pichler
Abstract: This invention is directed to compositions of the developer-coupler type of the dyeing of hair consisting essentially of resorcinol derivatives or salts thereof as coupling components and, as developer components, the conventional components used in oxidation dyes.
Abstract: This invention relates to a process for preparing oligophosphonic or oligophosphinic acids or esters or salts thereof which comprises reacting an alkali metal ester of phosphorous acid or an alkali metal ester of arylphosphonous or alkylphosphonous acid with an olefin polyhalide and, optionally, saponifying the resultant product.
Abstract: Compounds of the formula ##STR1## wherein one of A and B is methenyl (--CH.dbd.) and the other is carbonyl; R.sub.1 is (alkyl of 1 to 3 carbon atoms)mercapto, (alkyl of 1 to 3 carbon atoms)sulfinyl or (alkyl of 1 to 3 carbon atoms)sulfonyl; andR.sub.2 is alkoxy of 1 to 3 carbon atoms;tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds are useful as cardiotonics.
Type:
Grant
Filed:
December 5, 1984
Date of Patent:
February 4, 1986
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Volkhard Austel, Norbert Hauel, Joachim Heider, Manfred Reiffen, Jacobus C. A. Van Meel, Willi Diederen
Abstract: The invention relates to novel substituted 5,11-dihydro-6H-dibenz[b,e]azepin-6-one of the formula ##STR1## wherein A represents a (1-methyl-4-piperidinyl)-acetyl, (4-methyl-1-piperazinyl)-acetyl, or [(1-methyl-4-piperidinyl)-amino]-carbonyl group,and the acid addition salts thereof, which have valuable pharmacological properties, particularly an ulcer-inhibiting and secretion-inhibiting activity. The compounds of Formula I may be prepared using methods conventionally used for analogous compounds.
Type:
Grant
Filed:
January 7, 1985
Date of Patent:
January 28, 1986
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Wolfgang Eberlein, Gunter Trummlitz, Wolfhard Engel, Gunther Schmidt, Rudolf Hammer, Antonio Giachetti
Abstract: An aircraft propeller blade comprising an inner section which extends from the propeller hub toward the blade tip, a middle section adjacent to said inner section, and an outer section which extends from adjacent to said middle section to the blade tip; where the largest camber in the inner section decreases linearly over the blade length from adjacent to the propeller hub toward the blade tip, and the greatest camber height location shifts linearly over the blade length toward the blade tip; the largest camber in the middle section increases linearly over the blade length toward the blade tip, and the greatest camber height location shifts approximately linearly from adjacent to the inner section toward the blade tip; and the camber in the outer section decreases elliptically over the blade length toward the blade tip, and the greatest camber height location remains constant from adjacent to the middle section to the blade tip.
Type:
Grant
Filed:
October 11, 1983
Date of Patent:
January 14, 1986
Assignee:
Dornier Gesellschaft mit besehrankter Haftung
Inventors:
Herbert Zimmer, Ingo Dathe, Reinhard Hoffmann, Petr Hora, Franz X. Wortmann
Abstract: This invention relates to a topical cosmetic preparation for treating oily hair or seborrhea which contains a sebosuppressively effective amount of at least one 4-aryl-4-oxo-but-2-enoic acid derivative.
Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is phenylalkylamino, alkylamino, dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino;R.sub.2 is dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino; andR.sub.3 is halogen, alkoxy, alkylthio, phenylalkoxy or phenylalkylthio;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antithrombotics and antimetastatics.
Type:
Grant
Filed:
June 18, 1984
Date of Patent:
December 24, 1985
Assignee:
Dr. Karl Thomae Gesellschaft mit beschrankter Haftung
Inventors:
Josef Roch, Josef Nickl, Erich Muller, Berthold Narr, Johannes Weisenberger, Rainer Zimmermann, Walter Haarmann
Abstract: Compounds of the formula ##STR1## wherein n is 1 or 2, R.sub.1 is hydrogen, --CO--R.sub.2 or --SO.sub.2 R.sub.3,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or (alkyl of 1 to 4 carbon atoms)amino, andR.sub.3 is alkyl of 1 to 4 carbon atoms,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bronchospasmolytics.
Type:
Grant
Filed:
July 6, 1984
Date of Patent:
December 10, 1985
Assignee:
Boehringer Ingelheim KG
Inventors:
Anton Mentrup, Kurt Schromm, Ernst-Otto Renth, Gojko Muacevic, Armin Fugner
Abstract: Novel preformed, laminated plastic panels as semi-finished products comprising a plurality of individual laminated thermoplastic layers or thermoplastic layers arranged in partly differing orientations reinforced with unidirectionally preoriented short fibers comprising 20 to 80% of the layer volume, said laminate capable of being molded and/or deep drawn by hot pressing and/or hot molding at 70.degree. to 400.degree. C. and at a pressure of approximately 40 bar.
Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl (alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl (alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms; and their use as antihypertensives.
Type:
Grant
Filed:
January 19, 1984
Date of Patent:
November 26, 1985
Assignee:
Boehringer Ingelheim KG
Inventors:
Gerd Schnorrenberg, Otto Roos, Walter Losel, Ingrid Wiedemann, Wolfram Gaida, Wolfgang Hoefke
Abstract: Trimethylbicyclo [4.3.0] non-1-ene derivatives are fragrant substances which are suitable for use alone and in perfume and odorant compositions. Methods of preparation and representive compositions are also disclosed.
Abstract: Compounds of the formula ##STR1## wherein n is 0 or 1;A is methylene, vinylene or ethylene optionally substituted by lower alkyl;B is alkylene;R.sub.1 is an optionally substituted alkyl, phenyl or naphthyl group, or a cycloalkyl or pyridyl group; andR.sub.2 is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antithrombotics.
Type:
Grant
Filed:
January 26, 1984
Date of Patent:
November 5, 1985
Assignee:
Dr. Karl Thomae Gesellschaft mit beschrankter Haftung
Inventors:
Erich Muller, Josef Nickl, Berthold Narr, Josef Roch, Walter Haarmann, Johannes M. Weisenberger
Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is amino, acetylamino, hydroxymethyl, methoxymethyl or ##STR2## R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, methoxy, methyl or ethyl;R.sub.4 is straight or branched alkyl of 1 to 3 carbon atoms; andR.sub.5 and R.sub.6, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring where, in the case of a 6-membered ring, a --CH.sub.2 -group in the ring may be replaced by an oxygen atom,and non-toxic, pharmacologically acceptable salts thereof. The compounds as well as their salts are useful as antidepressants.
Type:
Grant
Filed:
July 23, 1984
Date of Patent:
October 29, 1985
Assignee:
Boehringer Ingelheim KG
Inventors:
Claus Schneider, Gerhard Walther, Karl-Heinz Weber, Wolf D. Bechtel, Karin Boke-Kuhn
Abstract: Compounds of the tautomeric formula ##STR1## wherein R, R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms;R.sub.3 is straight or branched alkyl, optionally interrupted by heteroatoms such as oxygen, sulfur or nitrogen; straight or branched alkenyl; alkynyl; cyano; cycloalkyl or cycloaliphatic alkyl; a bicyclic group; aryl; or a heterocyclic group; orR.sub.2 and R.sub.3, together with each other and the nitrogen atoms to which they are attached, form a heterocyclic group;R.sub.4 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms; andHet is a substituted or unsubstituted heterocycle containing two or three heteroatoms;tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.
Type:
Grant
Filed:
February 10, 1983
Date of Patent:
October 22, 1985
Assignee:
Istituto de Angeli S.p.A.
Inventors:
Giuseppe Bietti, Enzo Cereda, Arturo Donetti, Piero del Soldato, Antonio Giachetti, Rosamaria Micheletti
Abstract: This invention is directed to a method for the non-contact application of letters or symbols to the exterior surfaces of uncoated tablets or uncoated tablet cores, which comprises dotting color solution or suspension by means of an ink-jet printer in specific quantity in the form of discrete droplets of specific volume onto the exterior surfaces of the uncoated tablets or uncoated tablet cores.
Abstract: A novel divisible delayed release pharmaceutical tablet, wherein the rate of release of active ingredient is independent of the size and nature of the total surface area, and the fragments of which have the same characteristics of release of active ingredient as the undivided tablet.
Abstract: This invention is directed to terpene derivatives. More particularly, this invention relates to a mixture of isomers of the formula ##STR1## wherein R.sub.1 and R.sub.2, which are different from each other, are each methyl or isopropyl, the preparation thereof, and perfume compositions containing them.
Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or trifluoromethyl;R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, methyl or ethyl;R.sub.5 is hydrogen, alkyl of 1 to 8 carbon atoms, phenyl-(alkyl of 1 to 8 carbon atoms), cycloalkyl of 3 to 7 carbon atoms, (alkoxy of 1 to 4 carbon atoms) carbonyl-methyl, phenyl, substituted phenyl, naphthyl or substituted naphthyl; orR.sub.4 and R.sub.5, together with each other, are alkylene of 4 to 5 carbon atoms, optionally interrupted by --O-- or --NR.sub.6 --, where R.sub.6 is alkyl of 1 to 4 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics.
Type:
Grant
Filed:
October 31, 1983
Date of Patent:
October 8, 1985
Assignee:
Boehringer Ingelheim KG
Inventors:
Ernst-Otto Renth, Anton Mentrup, Kurt Schromm, Werner Traunecker, Richard Reichl