Abstract: Methods and compositions are provided that allow for high-level expression of a factor VIII polypeptide. More specifically, methods and compositions are provided comprising nucleic acid and amino acid sequences comprising a modified factor VIII that result in high-level expression of the polypeptide. The methods and compositions of the invention find use in the treatment of factor VIII deficiency including, for example, hemophilia A.

Abstract: Footwear with a powerful arch spring made with spring boards that can be utilized by the heel and ball of the foot areas during impact for efficient energy storage and return during walking, running and other forms of self propelled locomotion. The spring boards can extend into the toe area of the footwear to create a toe spring with efficient energy storage and return. Embodiments of the present invention combine the spring boards which are excellent for storing and returning energy with a shock absorbing material which can also function as a secondary spring in order to achieve high efficiency energy returns while maintaining comfort and stability with the footwear.