Patents Represented by Attorney Helen Greer

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  • LIL-Stat DNA binding sites and methods for identifying inhibitory binding agents
    Patent number: 5821053
    Abstract: A method for finding an agent which inhibits interaction between LIL-Stat protein and a nucleic acid having a LIL-Stat binding sequence is described. The LIL-Stat protein is contacted with the nucleic acid in the presence of an agent which inhibits or does not inhibit the interaction between the LIL-Stat protein and the nucleic acid. It is determined whether or not the agent inhibits this interaction. Also described are a method for treating an inflammatory response in a mammal, a therapeutic inhibitory agent suitable for treating or preventing an inflammatory response in a mammal, and DNA molecules having a DNA sequence encoding a binding site for the LIL-Stat protein.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: October 13, 1998
    Assignee: Center for Blood Research, Inc.
    Inventors: Philip E. Auron, Junichi Tsukada, Wayne R. Waterman, Andrew C. Webb
  • Prevention of probe coating on automated analyzers using a non-denaturing surfactant
    Patent number: 5786153
    Abstract: A method for substantially preventing coating of hydrophobic material on a probe of an automated analyzer during an assay is described. An automated analyzer having a probe is provided. A composition comprising a non-denaturing surfactant and a reagent for use in the assay is provided. The probe is contacted with the composition during the assay such that hydrophobic material is substantially prevented from coating the probe on the automated analyzer. Compositions for preventing such probe coating are also described. Methods and compositions comprising a non-denaturing surfactant for enhancing the stability of reagents used in an assay are also described.
    Type: Grant
    Filed: September 12, 1996
    Date of Patent: July 28, 1998
    Assignee: Chiron Diagnostics Corporation
    Inventors: Wei-Chao Ni, Anna Marie Detert, James Joseph Hughes
  • Use of antisense oligomers in a process for controlling contamination in nucleic acid amplification reactions
    Patent number: 5763186
    Abstract: A novel process for the use of antisense oligonucleotides and analogs thereof has been developed. Namely, this technique is useful for the elimination of contamination in the nucleic acid amplification area. Elimination of unwanted contamination has made gene probe analyses much more reproduceable.
    Type: Grant
    Filed: January 3, 1997
    Date of Patent: June 9, 1998
    Assignee: Chiron Diagnostics Corporation
    Inventors: Douglas N. Ludtke, John E. Monahan, John T. Unger
  • Method for diagnosing prostate cancer
    Patent number: 5654161
    Abstract: A method for diagnosing prostate cancer in a mammal is described. Serum from a mammal is provided. PSA is added to this serum, and the amount of ACT-PSA complex formed is measured. It is determined if the mammal has prostate cancer based on the amount of ACT-PSA complex that is formed. An isolated prostate cancer specific form of ACT which is capable of forming a stable complex with PSA is also described.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: August 5, 1997
    Assignee: Chiron Diagnostics Corporation
    Inventor: Prakash C. Tewari