Patents Represented by Attorney Henry H. Gu

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  • Intermediates in the preparation of entecavir via carbon-silicon oxidation
    Patent number: 7968555
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: June 28, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Process for preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
    Patent number: 7786300
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: August 31, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Process for the preparation of ?-chloroketones from alkyl esters
    Patent number: 6924397
    Abstract: The present invention relates to a process for the preparation of ?-chloroketones from readily available alkyl esters by the reaction of a sulfoxonium ylide on said alkyl esters to generate a keto sulfoxonium ylide that is in turn treated with anhydrous HCl.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: August 2, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: William Aloysius Nugent, Dengjin Wang
  • Process for the preparation of C-4 carbonate taxanes
    Patent number: 6916942
    Abstract: A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: July 12, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: John F. Kadow, Harold Mastalerz, Joydeep Kant, Qiufen May Xue, James G. Tarrant
  • Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
    Patent number: 6867300
    Abstract: Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: March 15, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jollie Duaine Godfrey, Jr., John Hynes, Jr., Alaric J. Dyckman, Katerina Leftheris, Zhongping Shi, Stephen T. Wrobleski, Wendel William Doubleday, John A. Grosso
  • Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
    Patent number: 6852745
    Abstract: Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: February 8, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Natesan Murugesan, John E. Tellew, John E. Macor, Zhengxiang Gu
  • Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
    Patent number: 6835741
    Abstract: Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: December 28, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Natesan Murugesan, John E. Tellew, John E. Macor, Zhengxiang Gu