Abstract: A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.
Type:
Grant
Filed:
October 1, 1987
Date of Patent:
October 17, 1989
Assignee:
Merck & Co., Inc.
Inventors:
Leeyuan Huang, Lawrence Koupal, Joseph Dunn, Jr., Jerrold M. Liesch, Otto Hensens, H. Boyd Woodruff
Abstract: The compounds of the following general structural formula (I) ##STR1## wherein R is hydrogen or a pharmaceutically acceptable salt thereof, are .beta.-ketoacyl-coenzyme A thiolase inhibitors and are useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
Abstract: A herpes simplex type 1 subunit vaccine is prepared from infected chick embryo cells by urea-extraction of the virus while the infected cells are still attached to the growth surface.
Type:
Grant
Filed:
September 11, 1980
Date of Patent:
March 2, 1982
Assignee:
Merck & Co., Inc.
Inventors:
Alexander U. Bertland, George P. Lampson
Abstract: Novel 6-methoxy and 6-thioalkyl-6-acylamidopenicillanic acids and their non-toxic pharmaceutically-acceptable salts, esters and amides which are useful as antibiotics. The products are prepared by treating an ester of 6-substituted-6-aminopenicillanic acid with an acylating agent followed by removal of the ester group. Also disclosed are novel intermediates.
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